problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl10093problendo-10093Research ArticleОбзорыReviewsВлияние соединений ванадия на нарушения углеводного и жирового обменаThe effect of vanadium compounds on carbohydrate and lipid metabolism disordershttps://orcid.org/0000-0002-2168-2659СидороваЮлия СергеевнаSidorovaYuliya S.

к.б.н.

PhD

sidorovaulia28@mail.ruhttps://orcid.org/0000-0003-1099-2560СкальнаяМаргарита ГеннадиевнаSkalnayaMargarita G.

д.м.н., профессор

MD, PhD, professor

skalnaya@yandex.ruhttps://orcid.org/0000-0003-0348-6192ТиньковАлексей АлексеевичTinkovAleksey A.

к.м.н.

MD, PhD

tinkov.a.a@gmail.comhttps://orcid.org/0000-0002-3237-7967МазоВладимир КимовичMazoVladimir K.

д.б.н., проф.

PhD, professor

mazo@ion.ru<p>Федеральный исследовательский центр питания, биотехнологии и безопасности пищи</p>Россия<p>Federal Research Centre of Nutrition, Biotechnology and Food Safety</p>Russian Federation<p class="Text05">Российский университет дружбы народов</p>Россия<p>RUDN University</p>Russian Federation<p>Российский университет дружбы народов; Ярославский государственный университет им. П.Г. Демидова</p>Россия<p>RUDN University; P.G. Demidov State University of Yaroslavl</p>Russian Federation201912092019653184190Copyright &#x00A9; Сидорова Ю.С., Скальная М.Г., Тиньков А.А., Мазо В.К., 20192019Сидорова Ю.С., Скальная М.Г., Тиньков А.А., Мазо В.К.Sidorova Y.S., Skalnaya M.G., Tinkov A.A., Mazo V.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/10093

Выяснение физиологической роли минорных биологически активных веществ, эссенциальность которых для организма человека на данном этапе развития нутрициологической науки не установлена, необходимо для уточнения качественного состава нутриома. Особый интерес представляет переходный металл – ванадий. Добавление ванадия к рациону животных с индуцированным или генетически обусловленным сахарным диабетом 2-го типа нормализует уровень глюкозы и инсулина крови, снижает резистентность к инсулину, способствует регенерации β-клеток, оказывает благоприятное воздействие на липидный обмен. Клинические исследования эффективности ванадия мало убедительны, в частности, из-за их недостаточной продолжительности. В обзоре кратко обсуждаются основные механизмы действия соединений ванадия. Терапевтические дозы соединений ванадия могут перекрываться токсическими дозами. Органические соединения ванадия могли бы применяться в существенно меньших дозах. Основной проблемой возможного использования соединений ванадия в антидиабетической терапии является соблюдение баланса между их благоприятным действием и неотделимыми рисками нежелательных эффектов.

At this stage in the development of nutriciological science, it has not been established if biologically active substances are essential to the human body; however, an explanation of the physiological role of minor biologically active substances is necessary to clarify the qualitative composition of Nutrioma. Of particular interest is the transition metal, vanadium. Adding vanadium to the diet of animals with induced or genetically determined type 2 diabetes mellitus normalizes glucose and blood insulin levels, reduces insulin resistance, promotes β-cell regeneration, and has a beneficial effect on lipid metabolism. Clinical studies of the effectiveness of vanadium are not convincing, in most part, because of their insufficient duration. The review briefly discusses the main mechanisms of the action of vanadium compounds. Therapeutic doses of vanadium compounds may overlap with toxic doses. Organic vanadium compounds could be used in significantly lower doses. The main problem with the possible use of vanadium compounds in antidiabetic therapy is the balance between their beneficial effects and the connected risks of side effects.

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The authors declare that there are no conflicts of interest present.