problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl199036283-86problendo-10542Research ArticleСтатьиArticlesКооперативный эффект глюкокортикоидов, адреналина и ЛПВП в регуляции активности гексокиназы печениCooperative effect of hydrocortisone, epinephrine and high density lipoproteins in the regulation of liver hexokinase activityПанинЛ ЕPaninL E-АтучинаН ВAtuchinaN V-ТретьяковаТ АTretyakovaT A-Научно-исследовательский институт биохимии СО РАМНScientific Research Institute of Biochemistry of Siberian Branch of Russian Academy of Medical Sciences199015121990362ТОМ 36, №2 (1990)8386Copyright © Панин Л.Е., Атучина Н.В., Третьякова Т.А., 19901990Панин Л.Е., Атучина Н.В., Третьякова Т.А.Panin L.E., Atuchina N.V., Tretyakova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/10542

The authors described a cooperative effect of glucocorticoids, catecholamines and high density lipoproteins (HDLP), based on increased hexokinase and glucokinase biosynthesis in the liver, resulting in elevated activity of the respective enzymes. This effect was completely blocked by actinomycin-D (a DNA-dependent inhibitor of RNA synthesis), vinblastine (an inhibitor of the microtubular apparatus and intracellular shift) and gordox (an inhibitor of serine proteinases). The modulating effect of HDLP with relation to the adaptive hormones emphasizes the cooperative nature of the new mechanism of enzymatic synthesis induction.

lipoproteinhexokinasehydrocortisonecooperative effecthigh density lipoproteins (HDLP)cooperative effect of glucocorticoidscatecholamines and high density lipoproteins (HDLP)References

The authors declare that there are no conflicts of interest present.