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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl19994538-10</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-10665</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Частота остеопении и динамика костной резорбции у женщин, больных сахарным диабетом II типа, в период менопаузы</article-title><trans-title-group xml:lang="en"><trans-title>The frequency of osteopenia and the dynamics of bone resorption in women with type II diabetes mellitus during menopause</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорян</surname><given-names>О. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoryan</surname><given-names>O. R.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернова</surname><given-names>Т. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernova</surname><given-names>T. O.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мешкова</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshkova</surname><given-names>I. P.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Игнатков</surname><given-names>В. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Ignatkov</surname><given-names>V. Ya.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анциферов</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Antsiferov</surname><given-names>M. B.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дедов</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dedov</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Эндокринологический научный центр РАМН&lt;em&gt;; &lt;/em&gt;РГМУ&lt;/p&gt;&#13;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinological Research Center of RAMS; RSMU&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>1999</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>1999</year></pub-date><volume>45</volume><issue>3</issue><issue-title>ТОМ 45, №3 (1999)</issue-title><fpage>8</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Григорян О.Р., Чернова Т.О., Мешкова И.П., Игнатков В.Я., Сергеева Н.А., Анциферов М.Б., Дедов И.И., 1999</copyright-statement><copyright-year>1999</copyright-year><copyright-holder xml:lang="ru">Григорян О.Р., Чернова Т.О., Мешкова И.П., Игнатков В.Я., Сергеева Н.А., Анциферов М.Б., Дедов И.И.</copyright-holder><copyright-holder xml:lang="en">Grigoryan O.R., Chernova T.O., Meshkova I.P., Ignatkov V.Y., Sergeeva N.A., Antsiferov M.B., Dedov I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/10665">https://www.probl-endojournals.ru/jour/article/view/10665</self-uri><abstract><p>Частота встречаемости остеопении у женщин, больных сахарным диабетом II типа, превышает средние популяционные нормы только в группе больных с нормальным индексом массы тела (ИМТ). Определение биохимического маркера резорбции костной ткани дезоксипиридинолина в моче выявляет обратную корреляционную связь между уровнем дезоксипиридинолина и ИМТ: чем меныие ИМТ, тем более выражен резорбтивный процесс в костной ткани. Отмечено положительное влияние заместительной гормональной терапии эстроген-гестагенными препаратами на резорбтивный процесс в костной ткани у женщин, больных СД II типа.</p></abstract><trans-abstract xml:lang="en"><p>The incidence of osteopenia in women with type 2 diabetes is higher than in the general population only in patients with normal body weight index (BWI). Measurement of biochemical marker of osseous tissue resorption, deoxypyridinolol (DPD), in the urine showed an inverse correlation between DPD level and BWI: the lower BWI, the more severe is bone resorption. Hormone replacing therapy (estrogen-gestagen preparations) had a favorable impact on bone resorption processes in women with type 2 diabetes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеопении</kwd><kwd>сахарный диабет</kwd><kwd>костная резорбция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteopenia</kwd><kwd>diabetes mellitus</kwd><kwd>bone resorption</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сметник В. П., Куитинский Н. Е., Любимова М., Болдырева Н. // Климактерий и постменопауза. — 1998. — № 1. — С. 23.</mixed-citation><mixed-citation xml:lang="en">Сметник В. П., Куитинский Н. Е., Любимова М., Болдырева Н. // Климактерий и постменопауза. — 1998. — № 1. — С. 23.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Barrett-Connor Е., Holbrook Т. L. // J. Amer. med. 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