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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl20065227-16</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-10847</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Выбор оптимального гестагена для комбинированной заместительной гормонотерапии в пери- и постменопаузе</article-title><trans-title-group xml:lang="en"><trans-title>Choice of optimal gestagen for combined hormonal replacement therapy in the peri- and postmenopause</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караченцев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Karachentsev</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельниченко</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnichenko</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">teofrast2000@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Медицинский центр в Коломенском - ЦМСЧ № 165 Федерального управления "Медбиоэкстрем" РФ&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Medical Center in Kolomenskoye - Central Medical Center No. 165 of the Federal Administration "Medbioextrem" of the Russian Federation&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>&lt;p&gt;ГУ Эндокринологический научный центр РАМН&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinology Research Centre&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>15</day><month>04</month><year>2006</year></pub-date><volume>52</volume><issue>2</issue><issue-title>ТОМ 52, №2 (2006)</issue-title><fpage>7</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Караченцев А.П., Мельниченко Г.А., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Караченцев А.П., Мельниченко Г.А.</copyright-holder><copyright-holder xml:lang="en">Karachentsev A.N., Melnichenko G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/10847">https://www.probl-endojournals.ru/jour/article/view/10847</self-uri><abstract><p>Менопауза, являясь завершением репродуктивного периода жизни женщины, характеризуется изменениями эндокринного равновесия в организме, значимо влияющими на здоровье, качество жизни и общий жизненный прогноз. Эти изменения могут быть более существенными и даже принимать фатальный характер при "вынужденной", искусственной (хирургической) менопаузе.</p></abstract><trans-abstract xml:lang="en"><p>Menopause, being the end of the reproductive period of a woman’s life, is characterized by changes in the endocrine balance in the body, significantly affecting health, quality of life and general life prognosis. These changes can be more significant and even take on a fatal character with "forced", artificial (surgical) menopause.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>перименопауза</kwd><kwd>постменопауза</kwd><kwd>гормональная терапия</kwd><kwd>гестагены</kwd></kwd-group><kwd-group xml:lang="en"><kwd>perimenopause</kwd><kwd>postmenopause hormone therapy</kwd><kwd>gestagens</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Грацианский Н. А. // Кардиология. - 1996. - Т. 36, № 6. -С. 4-18.</mixed-citation><mixed-citation xml:lang="en">Грацианский Н. А. // Кардиология. - 1996. - Т. 36, № 6. -С. 4-18.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Григорян О. Р., Чернова Т. О., Анциферов М. Б. // Пробл. репрод. - 2001. - Т. 7, № 4. - С. 53-61.</mixed-citation><mixed-citation xml:lang="en">Григорян О. Р., Чернова Т. О., Анциферов М. Б. // Пробл. репрод. - 2001. - Т. 7, № 4. - С. 53-61.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Григорян О. Р., Анциферов М. Б. // Акуш. и гин. - 2002. - № 5. - С. 51-54.</mixed-citation><mixed-citation xml:lang="en">Григорян О. Р., Анциферов М. Б. // Акуш. и гин. - 2002. - № 5. - С. 51-54.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Григорян О. Р., Анциферов М. Б. // Рус. мед. журн. - 2003. -Т. И, № 27. - С. 1518-1523.</mixed-citation><mixed-citation xml:lang="en">Григорян О. Р., Анциферов М. Б. // Рус. мед. журн. - 2003. -Т. И, № 27. - С. 1518-1523.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И И., Григорян О. Р., Чернова Т. О., Анциферов М. Б. Заместительная гормональная терапия у женщин, больных сахарным диабетом 2-го типа в климактерии: Практическое руководство. - М., 1999.</mixed-citation><mixed-citation xml:lang="en">Дедов И И., Григорян О. Р., Чернова Т. О., Анциферов М. Б. Заместительная гормональная терапия у женщин, больных сахарным диабетом 2-го типа в климактерии: Практическое руководство. - М., 1999.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Зайдиева Я. 3., Липатенкова Ю. И. // Гинекология. - 2000. - Т. 2, № 5. - http://www.consilium-medicum.com/ media/gynecology/00-05/</mixed-citation><mixed-citation xml:lang="en">Зайдиева Я. 3., Липатенкова Ю. И. // Гинекология. - 2000. - Т. 2, № 5. - http://www.consilium-medicum.com/ media/gynecology/00-05/</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Зайдиева Я. 3. // Гинекология. - 2003. - Т. 5, № 1. - С. 10-15.</mixed-citation><mixed-citation xml:lang="en">Зайдиева Я. 3. // Гинекология. - 2003. - Т. 5, № 1. - С. 10-15.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Караченцев А. Н., Сергеев П. В., Матюшин А. И. // Пробл. эндокринол. - 1996. - Т. 42, № 2. - С. 42-45.</mixed-citation><mixed-citation xml:lang="en">Караченцев А. Н., Сергеев П. В., Матюшин А. И. // Пробл. эндокринол. - 1996. - Т. 42, № 2. - С. 42-45.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Караченцев А. Н., Сергеев П. В. // Пробл. эндокринол. - 1997. - Т. 43, № 2. - С. 45-53.</mixed-citation><mixed-citation xml:lang="en">Караченцев А. Н., Сергеев П. В. // Пробл. эндокринол. - 1997. - Т. 43, № 2. - С. 45-53.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Караченцев А. Н., Кузнецова И. В. Ц Акуш. и гин. - 2004. -№3. - С-13-16.</mixed-citation><mixed-citation xml:lang="en">Караченцев А. Н., Кузнецова И. В. Ц Акуш. и гин. - 2004. -№3. - С-13-16.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Катхурия Ю. Б., Мельниченко Г. А., Чазова Т. Е. // Рус. мед. журн. - 2000. - Т. 8, № 18. - С. 764-767.</mixed-citation><mixed-citation xml:lang="en">Катхурия Ю. Б., Мельниченко Г. А., Чазова Т. Е. // Рус. мед. журн. - 2000. - Т. 8, № 18. - С. 764-767.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Катхурия Ю. Б., Калашникова М. Ф., Мельниченко Г. А. // Гинекология. - 2002. - Т. 4, № 1. - С. 35-38.</mixed-citation><mixed-citation xml:lang="en">Катхурия Ю. Б., Калашникова М. Ф., Мельниченко Г. А. // Гинекология. - 2002. - Т. 4, № 1. - С. 35-38.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Клиническая эффективность заместительной гормональной терапии: Пособие для врачей / Серов В. Н., Сметник В.П., Балан В. Е. и др. - М, 2001.</mixed-citation><mixed-citation xml:lang="en">Клиническая эффективность заместительной гормональной терапии: Пособие для врачей / Серов В. Н., Сметник В.П., Балан В. Е. и др. - М, 2001.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов С. Г., Доценко Ю. В., Санкова А. В. и др. // Кардиология. - 2002. - Т. 42, № 7. - С. 47-52.</mixed-citation><mixed-citation xml:lang="en">Козлов С. Г., Доценко Ю. В., Санкова А. В. и др. // Кардиология. - 2002. - Т. 42, № 7. - С. 47-52.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Краснова И. А., Сущевич Л. В., Климова И. В. и др. // Вестн. Рос. ассоц. акуш.-гин. - 2001. - № 1. - С. 68- 72.</mixed-citation><mixed-citation xml:lang="en">Краснова И. А., Сущевич Л. В., Климова И. В. и др. // Вестн. Рос. ассоц. акуш.-гин. - 2001. - № 1. - С. 68- 72.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Майчук Е. Ю., Юренева С. В., Печенкина И. В., Мартынов А. И. // Рус. мед. журн. - 2003. - Т. 11, № 9. - С. 507- 510.</mixed-citation><mixed-citation xml:lang="en">Майчук Е. Ю., Юренева С. В., Печенкина И. В., Мартынов А. И. // Рус. мед. журн. - 2003. - Т. 11, № 9. - С. 507- 510.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Попков С. А., Гуревич К. Г., Булгаков Р. В., Лебедь С. В. // . Гинекология. - 2002. - Т. 4, № 2. - http://www.consilium-medicum.com/media/gynecology/02_02/</mixed-citation><mixed-citation xml:lang="en">Попков С. А., Гуревич К. Г., Булгаков Р. В., Лебедь С. В. // . Гинекология. - 2002. - Т. 4, № 2. - http://www.consilium-medicum.com/media/gynecology/02_02/</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Репина М. А. // Гинекология. - 2001. - Т. 3, № 4. - c.120-124.</mixed-citation><mixed-citation xml:lang="en">Репина М. А. // Гинекология. - 2001. - Т. 3, № 4. - c.120-124.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Рубченко Г. И., Краснопольский В. И., Лукашенко С. Ю. и др. // Пробл. репрод. - 1999. - № 3. - http://www.rusmedserv.com/problreprod/3-99/</mixed-citation><mixed-citation xml:lang="en">Рубченко Г. И., Краснопольский В. И., Лукашенко С. Ю. и др. // Пробл. репрод. - 1999. - № 3. - http://www.rusmedserv.com/problreprod/3-99/</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по климактерию: Руководство для врачей / Под ред. В. П. Сметник, В. И. Кулакова. - М., 2001.</mixed-citation><mixed-citation xml:lang="en">Руководство по климактерию: Руководство для врачей / Под ред. В. П. Сметник, В. И. Кулакова. - М., 2001.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Савельева Г. М., Бреусенко В. Г., Крюченкова М. Е. и др. // Рус. мед. журн. - 1999. - Т. 1, № 1. - http:// www.rmj.net/practgin/tl/nl/</mixed-citation><mixed-citation xml:lang="en">Савельева Г. М., Бреусенко В. Г., Крюченкова М. Е. и др. // Рус. мед. журн. - 1999. - Т. 1, № 1. - http:// www.rmj.net/practgin/tl/nl/</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Санкова А. В., Григорян О. Р., Козлов С. Г. и др. // Пробл. репрод. - 1999. - № 5. - http://www.rusmedserv.com/ problreprod/5-99/</mixed-citation><mixed-citation xml:lang="en">Санкова А. В., Григорян О. Р., Козлов С. Г. и др. // Пробл. репрод. - 1999. - № 5. - http://www.rusmedserv.com/ problreprod/5-99/</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Серебренникова К. Г., Чумакова Я. В. // Гинекология. - 2003.- Т. 5, № 4. - С. 147-151.</mixed-citation><mixed-citation xml:lang="en">Серебренникова К. Г., Чумакова Я. В. // Гинекология. - 2003.- Т. 5, № 4. - С. 147-151.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Сметник В. П. // Consilium Medicum. - 2002. - Т. 4, № 10. - С. 13-16.</mixed-citation><mixed-citation xml:lang="en">Сметник В. П. // Consilium Medicum. - 2002. - Т. 4, № 10. - С. 13-16.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Сметник В. П., Kloosterboer H.J. // Климактерий. - 2003. -№ 1. - С. 1-4.</mixed-citation><mixed-citation xml:lang="en">Сметник В. П., Kloosterboer H.J. // Климактерий. - 2003. -№ 1. - С. 1-4.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Сторожаков Г. И., Стародубова А. В., Кисляк О. А. // Сердце. - 2003. - Т. 2, № 3. - С. 137-140.</mixed-citation><mixed-citation xml:lang="en">Сторожаков Г. И., Стародубова А. В., Кисляк О. А. // Сердце. - 2003. - Т. 2, № 3. - С. 137-140.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Тихомиров А. Л., Олейник Ч. Г. // Рус. мед. журн. - 2003. -Т. 11, № 16. - http://www.rmj.ru/</mixed-citation><mixed-citation xml:lang="en">Тихомиров А. Л., Олейник Ч. Г. // Рус. мед. журн. - 2003. -Т. 11, № 16. - http://www.rmj.ru/</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Тихомиров А. Л., Олейник Ч. Г. // Рус. мед. журн. - 2003. -Т. 11, № 14. - http://www.rmj.ru/</mixed-citation><mixed-citation xml:lang="en">Тихомиров А. Л., Олейник Ч. Г. // Рус. мед. журн. - 2003. -Т. 11, № 14. - http://www.rmj.ru/</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Хашаева Т. X., Эседова А. Э. Ц Гинекология. - 2001. - Т. 3, № 1. - http://www.consilium-medicum.com/media/gynecology/01_01/</mixed-citation><mixed-citation xml:lang="en">Хашаева Т. X., Эседова А. Э. Ц Гинекология. - 2001. - Т. 3, № 1. - http://www.consilium-medicum.com/media/gynecology/01_01/</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson В., Mattsson L. A., Hahn L. et al. // J. Clin. Endocrinol. Metab. - 1997. - Vol. 82. - P. 638-643.</mixed-citation><mixed-citation xml:lang="en">Andersson В., Mattsson L. A., Hahn L. et al. // J. Clin. Endocrinol. Metab. - 1997. - Vol. 82. - P. 638-643.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bar J., Tepper R., Fuchs J. et al. // Obstet. and Gynecol. - 1993. - Vol. 81. - P. 261-264.</mixed-citation><mixed-citation xml:lang="en">Bar J., Tepper R., Fuchs J. et al. // Obstet. and Gynecol. - 1993. - Vol. 81. - P. 261-264.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Borgfeldt C, Li C, Samsioe G. // Climacteric. - 2004. - Vol. 7, N 1. - P. 78-85.</mixed-citation><mixed-citation xml:lang="en">Borgfeldt C, Li C, Samsioe G. // Climacteric. - 2004. - Vol. 7, N 1. - P. 78-85.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Cagnacci A., Arangino S., Baldassari F. et al. // Maturitas. - 2004.- Vol. 48, N 4. - P. 456-462.</mixed-citation><mixed-citation xml:lang="en">Cagnacci A., Arangino S., Baldassari F. et al. // Maturitas. - 2004.- Vol. 48, N 4. - P. 456-462.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Chang T. C, Lien Y. R., Chen M. et al. // Acta Obstet. Gynecol. Scand. - 2004. - Vol. 83, N 7. - P. 661-666.</mixed-citation><mixed-citation xml:lang="en">Chang T. C, Lien Y. R., Chen M. et al. // Acta Obstet. Gynecol. Scand. - 2004. - Vol. 83, N 7. - P. 661-666.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Lignieres B. // Clin. Then - 1999. - Vol. 21. - P. 41- 60.</mixed-citation><mixed-citation xml:lang="en">Lignieres B. // Clin. Then - 1999. - Vol. 21. - P. 41- 60.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Espeland M. A., Hogan P. E., Fineberg S. E. et al. // Diabetes Care. - 1998. - Vol. 21, N 10. - P. 1589-1595.</mixed-citation><mixed-citation xml:lang="en">Espeland M. A., Hogan P. E., Fineberg S. E. et al. // Diabetes Care. - 1998. - Vol. 21, N 10. - P. 1589-1595.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Genazzani A. R. // Maturitas. - 2001. - Vol. 38. - P. 263- 271.</mixed-citation><mixed-citation xml:lang="en">Genazzani A. R. // Maturitas. - 2001. - Vol. 38. - P. 263- 271.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Godsland I. F. // Fertil. and Steril. - 2001. - Vol. 75, N 5. -P. 898-915.</mixed-citation><mixed-citation xml:lang="en">Godsland I. F. // Fertil. and Steril. - 2001. - Vol. 75, N 5. -P. 898-915.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Godsland I. F., Manassiev N. A., Felton C. V. et al. // Clin. Endocrinol. (Oxford). - 2004. - Vol. 60, N 5. - P. 541- 549.</mixed-citation><mixed-citation xml:lang="en">Godsland I. F., Manassiev N. A., Felton C. V. et al. // Clin. Endocrinol. (Oxford). - 2004. - Vol. 60, N 5. - P. 541- 549.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Goeretzleher G. // Drugs of Today. - 2001. - Vol. 37. - Suppl. G. - P. 1-3.</mixed-citation><mixed-citation xml:lang="en">Goeretzleher G. // Drugs of Today. - 2001. - Vol. 37. - Suppl. G. - P. 1-3.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Graham J., Clarke C. // Endocr. Rev. - 1997. - Vol. 18, N 4. - P. 502-515.</mixed-citation><mixed-citation xml:lang="en">Graham J., Clarke C. // Endocr. Rev. - 1997. - Vol. 18, N 4. - P. 502-515.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Graser Т., Koytchev R., Romer T. et al. // Drugs of Today. - 1999. - Vol. 35. - Suppl. C. - P. 115-126.</mixed-citation><mixed-citation xml:lang="en">Graser Т., Koytchev R., Romer T. et al. // Drugs of Today. - 1999. - Vol. 35. - Suppl. C. - P. 115-126.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Graser T. // Drugs of Today. - 2001. - Vol. 37. - Suppl. G. -P. 87-99.</mixed-citation><mixed-citation xml:lang="en">Graser T. // Drugs of Today. - 2001. - Vol. 37. - Suppl. G. -P. 87-99.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Graser Т., Romer Т., Wiedey K, Janaud A. // Climacteric. - 2001. - Vol. 4. - P. 332-342.</mixed-citation><mixed-citation xml:lang="en">Graser Т., Romer Т., Wiedey K, Janaud A. // Climacteric. - 2001. - Vol. 4. - P. 332-342.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Hogervost E., Boshuissen M., Riedel W. et al. // Psychoneuroendocrinology. - 1999. - Vol. 24. - P. 43-68.</mixed-citation><mixed-citation xml:lang="en">Hogervost E., Boshuissen M., Riedel W. et al. // Psychoneuroendocrinology. - 1999. - Vol. 24. - P. 43-68.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Hulley S., Grady D., Bush T. et al. // J. A. M. A. - 1998. - Vol. 280. - P. 605-613.</mixed-citation><mixed-citation xml:lang="en">Hulley S., Grady D., Bush T. et al. // J. A. M. A. - 1998. - Vol. 280. - P. 605-613.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Isomaa В., Almgren P., Tuomi T. et al. // Diabetes Care. - 2001. - Vol. 24. - P. 683-689.</mixed-citation><mixed-citation xml:lang="en">Isomaa В., Almgren P., Tuomi T. et al. // Diabetes Care. - 2001. - Vol. 24. - P. 683-689.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Kanaya A. M., Herrington D., Vitinghoff E. et al. // Ann. Intern. Med. - 2003. - Vol. 138, N 1. - P. 1-9.</mixed-citation><mixed-citation xml:lang="en">Kanaya A. M., Herrington D., Vitinghoff E. et al. // Ann. Intern. Med. - 2003. - Vol. 138, N 1. - P. 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Kuhl H. //Drugs of Today. - 1996. - Vol. 32. - Suppl. H. -P. 25-31</mixed-citation><mixed-citation xml:lang="en">Kuhl H. //Drugs of Today. - 1996. - Vol. 32. - Suppl. H. -P. 25-31</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lauritzen С // Gynakol. Prax. - 2000. - Bd 24. - S. 251-260.</mixed-citation><mixed-citation xml:lang="en">Lauritzen С // Gynakol. Prax. - 2000. - Bd 24. - S. 251-260.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">McKenzie J., Jaap A. J., Gallacher S. et al. // Obstet. Gynecol. Surv. - 2004. - Vol. 59, N 7. - P. 524-525.</mixed-citation><mixed-citation xml:lang="en">McKenzie J., Jaap A. J., Gallacher S. et al. // Obstet. Gynecol. Surv. - 2004. - Vol. 59, N 7. - P. 524-525.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Morin-Papunen L. C, Vauhkonen I., Ruokonen A. et al. // Eur.J. Endocrinol. - 2004. - Vol. 150, N 5. - P. 705-714.</mixed-citation><mixed-citation xml:lang="en">Morin-Papunen L. C, Vauhkonen I., Ruokonen A. et al. // Eur.J. Endocrinol. - 2004. - Vol. 150, N 5. - P. 705-714.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Natale V., Albertazzi M., Zini M. et al. // Br. J. Obstet. Gyne col. - 2001. - Vol. 108. - P. 286-290.</mixed-citation><mixed-citation xml:lang="en">Natale V., Albertazzi M., Zini M. et al. // Br. J. Obstet. Gyne col. - 2001. - Vol. 108. - P. 286-290.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Oettel M., Graser Т., Hoffman H. // Drugs of Today. - 2001. -Vol. 37. - Suppl. G. - P. 3-15.</mixed-citation><mixed-citation xml:lang="en">Oettel M., Graser Т., Hoffman H. // Drugs of Today. - 2001. -Vol. 37. - Suppl. G. - P. 3-15.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Okada M., Nomura S., Ikoma Y. et al. // Diabetes Care. - 2003.- Vol. 26, N 4. - P. 1088-1092.</mixed-citation><mixed-citation xml:lang="en">Okada M., Nomura S., Ikoma Y. et al. // Diabetes Care. - 2003.- Vol. 26, N 4. - P. 1088-1092.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Pike M. a, Ross R. K. // Steroids. - 2000. - Vol. 65. - P. 659-664.</mixed-citation><mixed-citation xml:lang="en">Pike M. a, Ross R. K. // Steroids. - 2000. - Vol. 65. - P. 659-664.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Saktu B. // Drugs of Today. - 2001. - Vol. 37. - Suppl. G. -P. 39-62.</mixed-citation><mixed-citation xml:lang="en">Saktu B. // Drugs of Today. - 2001. - Vol. 37. - Suppl. G. -P. 39-62.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Sanada M., Tsuda M., Kodama I. et al. // Menopause. - 2004.- Vol. 11, N 3. - P. 331-336.</mixed-citation><mixed-citation xml:lang="en">Sanada M., Tsuda M., Kodama I. et al. // Menopause. - 2004.- Vol. 11, N 3. - P. 331-336.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Santen R. J., Pinkerton J., McCartney C, Petroni G. R. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86, N 1. - P. 16-23.</mixed-citation><mixed-citation xml:lang="en">Santen R. J., Pinkerton J., McCartney C, Petroni G. R. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86, N 1. - P. 16-23.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Schindler A. E. // Gynecol. Endocrinol. - 1999. - Vol. 13. - Suppl. 6. - P. 35-40.</mixed-citation><mixed-citation xml:lang="en">Schindler A. E. // Gynecol. Endocrinol. - 1999. - Vol. 13. - Suppl. 6. - P. 35-40.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider H. Hormone Replacement Therapy and Quality of Life. - Camforth, 2002.</mixed-citation><mixed-citation xml:lang="en">Schneider H. Hormone Replacement Therapy and Quality of Life. - Camforth, 2002.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Shah S. H., Alexander К. P..// Curr. Treat. Opt. Cardiovasc. Med. - 2003. - Vol. 5, N 1. - P. 25-33.</mixed-citation><mixed-citation xml:lang="en">Shah S. H., Alexander К. P..// Curr. Treat. Opt. Cardiovasc. Med. - 2003. - Vol. 5, N 1. - P. 25-33.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Sitruk-Ware R. // J. North Am. Menopaus. Soc. - 2002. - Vol. 9, N 1. - P. 6-15.</mixed-citation><mixed-citation xml:lang="en">Sitruk-Ware R. // J. North Am. Menopaus. Soc. - 2002. - Vol. 9, N 1. - P. 6-15.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Spences C. P., Godsland L. F., Stevenson J. C. // J. Gynecol. Endocrinol. - 1997. - Vol. 11, N 5. - P. 341-355.</mixed-citation><mixed-citation xml:lang="en">Spences C. P., Godsland L. F., Stevenson J. C. // J. Gynecol. Endocrinol. - 1997. - Vol. 11, N 5. - P. 341-355.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Stevenson J. C, Crook D., Godsland I. F. et al. // Drugs. - 1994. - Vol. 47. - Suppl. 2. - P. 35-41.</mixed-citation><mixed-citation xml:lang="en">Stevenson J. C, Crook D., Godsland I. F. et al. // Drugs. - 1994. - Vol. 47. - Suppl. 2. - P. 35-41.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Stevenson J. C, Teter P., Lees B. // Maturitas. - 2001. - Vol. 38, N 2. - P. 197-203.</mixed-citation><mixed-citation xml:lang="en">Stevenson J. C, Teter P., Lees B. // Maturitas. - 2001. - Vol. 38, N 2. - P. 197-203.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Tobias J. H. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86.-P. 1194-1198.</mixed-citation><mixed-citation xml:lang="en">Tobias J. H. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86.-P. 1194-1198.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">U. S. Preventive Task Force (USPSTF) // Ann. Intern. Med. -2002. - Vol. 137. - P. 834-839.</mixed-citation><mixed-citation xml:lang="en">U. S. Preventive Task Force (USPSTF) // Ann. Intern. Med. -2002. - Vol. 137. - P. 834-839.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Utian W. H., Gass M. L, Pickar J. H. // Menopause. - 2004. -Vol. 1, N 3. - P. 306-314.</mixed-citation><mixed-citation xml:lang="en">Utian W. H., Gass M. L, Pickar J. H. // Menopause. - 2004. -Vol. 1, N 3. - P. 306-314.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Weintraub M. S, Grosskopf I., Charach G. et al. // Arch. Intern. Med. - 1998. - Vol. 158. - P. 1803-1806.</mixed-citation><mixed-citation xml:lang="en">Weintraub M. S, Grosskopf I., Charach G. et al. // Arch. Intern. Med. - 1998. - Vol. 158. - P. 1803-1806.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
