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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl200652639-41</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-10903</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В помощь практикующему врачу</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>For practitioners</subject></subj-group></article-categories><title-group><article-title>Диагностика инсулинорезистентности у детей и подростков</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis of insulin resistance in children and adolescents</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Витебская</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vitebskaya</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Институт детской эндокринологии (дир. - проф. В. А. Петеркова)</p></bio><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васюкова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyukova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Институт детской эндокринологии (дир. - проф. В. А. Петеркова)</p></bio><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;ГУ Эндокринологический научный центр РАМН&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinology Research Centre&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2006</year></pub-date><volume>52</volume><issue>6</issue><issue-title>ТОМ 52, №6 (2006)</issue-title><fpage>39</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Витебская А.В., Васюкова О.В., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Витебская А.В., Васюкова О.В.</copyright-holder><copyright-holder xml:lang="en">Vitebskaya A.V., Vasyukova O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/10903">https://www.probl-endojournals.ru/jour/article/view/10903</self-uri><abstract><p>Высокая распространенность ожирения у детей является одним из факторов, способствующих увеличению частоты развития метаболического синдрома и связанных с ним заболеваний. Ключевую роль в развитии метаболического синдрома, как у детей, так и у взрослых, играет инсулинорезистентность — нарушение биологического действия инсулина и реакции на него инсулин-чувствительных тканей на пре-, пост- и рецепторном уровнях,</p></abstract><trans-abstract xml:lang="en"><p>The high prevalence of obesity in children is one of the factors contributing to an increase in the frequency of development of the metabolic syndrome and related diseases. A key role in the development of the metabolic syndrome in both children and adults is played by insulin resistance - a violation of the biological effect of insulin and the reaction of insulin-sensitive tissues to it at the pre-, post- and receptor levels.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>инсулинорезистентность</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>insulin resistance</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Петеркова В. А., Ремизов О. В. // Ожирение / Под ред. И. И. Дедова, Г. А. Мельниченко. - М., 2004. - С. 312- 328.</mixed-citation><mixed-citation xml:lang="en">Петеркова В. А., Ремизов О. В. // Ожирение / Под ред. И. И. Дедова, Г. А. Мельниченко. - М., 2004. - С. 312- 328.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bergman R. N., Prager R., Volund A. et al. // J. Clin. Invest. - 1987. - Vol. 79. - P. 790-800.</mixed-citation><mixed-citation xml:lang="en">Bergman R. N., Prager R., Volund A. et al. // J. Clin. Invest. - 1987. - Vol. 79. - P. 790-800.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cam J. F. // J. Clin. Endocrinol. Metab. Rev. - 1991. - Vol. 73, N 4. - P. 691-695.</mixed-citation><mixed-citation xml:lang="en">Cam J. F. // J. Clin. Endocrinol. Metab. Rev. - 1991. - Vol. 73, N 4. - P. 691-695.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Con-well L. S., Trost S. G., Brown W. J. et al. // Diabetes Care. - 2004. - Vol. 27. - P. 314-319.</mixed-citation><mixed-citation xml:lang="en">Con-well L. S., Trost S. G., Brown W. J. et al. // Diabetes Care. - 2004. - Vol. 27. - P. 314-319.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">De Fronzo R., Ferranninl E. // Diabetes Care. - 1991. - Vol. 14. - P. 173-194.</mixed-citation><mixed-citation xml:lang="en">De Fronzo R., Ferranninl E. // Diabetes Care. - 1991. - Vol. 14. - P. 173-194.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Goran M. I., Gower B. A. // Diabetes. - 2001. - Vol. 50. - P. 244-245.</mixed-citation><mixed-citation xml:lang="en">Goran M. I., Gower B. A. // Diabetes. - 2001. - Vol. 50. - P. 244-245.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Heinze E., Holl R. W. // Diagnostics of Endocrine Function in Children and Adolescents / Ed. M. B. Ranke. - Heidelberg; Leipzig, 1995. - P. 299-313.</mixed-citation><mixed-citation xml:lang="en">Heinze E., Holl R. W. // Diagnostics of Endocrine Function in Children and Adolescents / Ed. M. B. Ranke. - Heidelberg; Leipzig, 1995. - P. 299-313.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Katz A., Nambl S. S, Mather K. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85. N 7. - P. 2402-2410.</mixed-citation><mixed-citation xml:lang="en">Katz A., Nambl S. S, Mather K. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85. N 7. - P. 2402-2410.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Keskin M., Kurtoglu S., Kendtrcl M. et al. // Pediatrics. - 2005. - Vol. 115, N 4. - P. 500-503.</mixed-citation><mixed-citation xml:lang="en">Keskin M., Kurtoglu S., Kendtrcl M. et al. // Pediatrics. - 2005. - Vol. 115, N 4. - P. 500-503.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lautala P., Akerblom H. K., Vikari J. et al. // Acta Paediatr. Scand. - 1985. - Suppl. 318. - P. 127-133.</mixed-citation><mixed-citation xml:lang="en">Lautala P., Akerblom H. K., Vikari J. et al. // Acta Paediatr. Scand. - 1985. - Suppl. 318. - P. 127-133.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuda M., DeFronzo R. A. // Diabetes Care. - 1999. - Vol. 22. - P. 1462-1470.</mixed-citation><mixed-citation xml:lang="en">Matsuda M., DeFronzo R. A. // Diabetes Care. - 1999. - Vol. 22. - P. 1462-1470.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mattews D. R., Hosker J. P., Rudenski A. S. et al. // Diabetologia. - 1985. - Vol. 28. - P. 412-419.</mixed-citation><mixed-citation xml:lang="en">Mattews D. R., Hosker J. P., Rudenski A. S. et al. // Diabetologia. - 1985. - Vol. 28. - P. 412-419.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Stern J., Hirsch J., Blair S. N. et al. // Obes. Res. - 1995. - Vol. 3, N 6. - P. 591-604.</mixed-citation><mixed-citation xml:lang="en">Stern J., Hirsch J., Blair S. N. et al. // Obes. Res. - 1995. - Vol. 3, N 6. - P. 591-604.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Uwaifo G. I., Fallon E. M., Chin J. et al. // Diabetes Care. - 2002. - Vol. 25. - P. 2081-2087.</mixed-citation><mixed-citation xml:lang="en">Uwaifo G. I., Fallon E. M., Chin J. et al. // Diabetes Care. - 2002. - Vol. 25. - P. 2081-2087.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace T. A., Levy J. C., Mattews D. R. // Diabetes Care. - 2004. - Vol. 27, N 6. - P. 1487-1495.</mixed-citation><mixed-citation xml:lang="en">Wallace T. A., Levy J. C., Mattews D. R. // Diabetes Care. - 2004. - Vol. 27, N 6. - P. 1487-1495.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Yeckel C. W., Weiss R., Dziura J. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 3. - P. 1096-1101.</mixed-citation><mixed-citation xml:lang="en">Yeckel C. W., Weiss R., Dziura J. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 3. - P. 1096-1101.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
