<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl200854516-20</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Диагностическая точность тонкоигольной аспирационной биопсии щитовидной железы под ультразвуковым контролем и морфологическая структура узлового зоба у детей и подростков</article-title><trans-title-group xml:lang="en"><trans-title>The diagnostic accuracy of fine-needle biopsy of the thyroid under ultra-sound guidance and the morphological structure of nodular goiter in children and adolescents</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кияев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiyaev</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yeliseyeva</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королева</surname><given-names>Н. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Koroleva</surname><given-names>N. P.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Областная детская клиническая больница № 1</institution></aff><aff xml:lang="en"><institution>Regional Children's Clinical Hospital № 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2008</year></pub-date><volume>54</volume><issue>5</issue><issue-title>ТОМ 54, №5 (2008)</issue-title><fpage>16</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кияев А.В., Елисеева Н.А., Королева Н.П., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Кияев А.В., Елисеева Н.А., Королева Н.П.</copyright-holder><copyright-holder xml:lang="en">Kiyaev A.V., Yeliseyeva N.A., Koroleva N.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11039">https://www.probl-endojournals.ru/jour/article/view/11039</self-uri><abstract><p>В период с 2000 по 2007 г. 202 детям и подросткам (167 девочек и 35 мальчиков) в возрасте от 7,2 до 17,7 года (медиана 15,6 года) проведена тонкоигольная аспирационная биопсия (TAB) щитовидной железы под ультразвуковым контролем. В 20 (9,99с) случаях цитологические препараты оказались неинформативными. При размерах углов менее 10мм частота информативных биопсий была достоверно ниже, чем при узлах диаметром 1см и больше (63,2% против 94,9%; х2 - 23,23; р = 0,000). 41 пациент был прооперирован:рак щитовидной железы (ЩЖ) - 21, фолликулярная аденома - 15, коллоидный зоб - 5. Доля рака ЩЖ в морфологической структуре углового зоба составила 11,5% (21 из 1S2 информативных ТАБ). Высокая точность метода ТАБ под ультразвуковым контролем в диагностике опухолей ЩЖ (чувствительность 97,2%; специфичность 80%; точность 95,1%) определяет адекватную тактику в отношении угюв ЩЖ у детей и подростков</p></abstract><trans-abstract xml:lang="en"><p>In 2000 to 2007, fine-needle biopsy (FNB) of the thyroid was made under ultrasound guidance in 202 children and adolescents (35 boys and 167 girls) aged 7.2 to 17.7 years (median 15.6 years). Cytological specimens proved to be of informative value in 20(9.9%) cases. If the size of nodules was less than 10 mm, the frequency of informative biopsies was significantly lower than if the size was 1 cm or more (63.2% versus 94.9%; х2 = 23.23; p = 0.000). Forty-one patients were operated on for thyroid cancer (n = 21), follicular adenoma (n - 15), and colloidal goiter (n = 5). The proportion of thyroid cancer in the morphological pattern of nodular goiter was 11.5% (21 of 182 informative FNBs). The high accuracy of FNB under ultrasound guidance in the diagnosis of thyroid tumors (97.2% sensitivity, 80% specificity, 95.1% accuracy) determines adequate treatment policy against thyroid nodules in children and adolescents.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>тонкоигольная аспирационная биопсия</kwd><kwd>узлы щитовидной железы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>fine-needle biopsy</kwd><kwd>thyroid nodules</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И. И., Мельниченко Г. А., Фадеев В. В. и др. // Пробл. эидокринол. - 2005. - № 5. - С. 40-42.</mixed-citation><mixed-citation xml:lang="en">Дедов И. И., Мельниченко Г. А., Фадеев В. В. и др. // Пробл. эидокринол. - 2005. - № 5. - С. 40-42.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И. И., Петеркова В. А. Руководство по детской эндокринологии. - М., 2006.</mixed-citation><mixed-citation xml:lang="en">Дедов И. И., Петеркова В. А. Руководство по детской эндокринологии. - М., 2006.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">AACE Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer // Endocr. Pract. -2006. - Vol. 12. - P. 63-102.</mixed-citation><mixed-citation xml:lang="en">AACE Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer // Endocr. Pract. -2006. - Vol. 12. - P. 63-102.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Shairh A., Ngan В., Daneman A., Daneman D. // J. Pediatr. -2001. - Vol. 138. - P. 140-142.</mixed-citation><mixed-citation xml:lang="en">Al-Shairh A., Ngan В., Daneman A., Daneman D. // J. Pediatr. -2001. - Vol. 138. - P. 140-142.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">The American Thyroid Association Guidelines Taskforce:</mixed-citation><mixed-citation xml:lang="en">The American Thyroid Association Guidelines Taskforce:</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cooper D. S., Doherty G. M., Haugen B. R. et al. // Thyroid. -2006. - Vol. 6, N 2. - P. 1-33.</mixed-citation><mixed-citation xml:lang="en">Cooper D. S., Doherty G. M., Haugen B. R. et al. // Thyroid. -2006. - Vol. 6, N 2. - P. 1-33.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Amrikachl M., Ponder Т. В., Wheeler T. M. et al. // Diagn. Cytopathol. - 2005. - Vol. 32. - P. 189-192.</mixed-citation><mixed-citation xml:lang="en">Amrikachl M., Ponder Т. В., Wheeler T. M. et al. // Diagn. Cytopathol. - 2005. - Vol. 32. - P. 189-192.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Arda I. S., Yildirim S., Demirhan В., Firat S. // Arch. Dis. Child. - 2001. - Vol. 85. - P. 313-317.</mixed-citation><mixed-citation xml:lang="en">Arda I. S., Yildirim S., Demirhan В., Firat S. // Arch. Dis. Child. - 2001. - Vol. 85. - P. 313-317.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ardito С, Pintus С, Revelli L et al. // Eur. J. Pediatr. Surg. - 2001.-Vol. 11. -P. 154-157.</mixed-citation><mixed-citation xml:lang="en">Ardito С, Pintus С, Revelli L et al. // Eur. J. Pediatr. Surg. - 2001.-Vol. 11. -P. 154-157.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chang S. H., Joo M., Kim H. // J. Korean Med. Sci. - 2006. -Vol. 21. - P. 469-473.</mixed-citation><mixed-citation xml:lang="en">Chang S. H., Joo M., Kim H. // J. Korean Med. Sci. - 2006. -Vol. 21. - P. 469-473.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Corrias A., Einaudi S., Chlorboli E. // J. Clin. Endocrinol. - 2001. - Vol. 86, N 10. - P. 4644-4648.</mixed-citation><mixed-citation xml:lang="en">Corrias A., Einaudi S., Chlorboli E. // J. Clin. Endocrinol. - 2001. - Vol. 86, N 10. - P. 4644-4648.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Degnan B. M., McClellan D. R., Francis G. L. // J. Pediatr. Surg. - 1996. - Vol. 31. - P. 903-907.</mixed-citation><mixed-citation xml:lang="en">Degnan B. M., McClellan D. R., Francis G. L. // J. Pediatr. Surg. - 1996. - Vol. 31. - P. 903-907.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hamburger J. I., Husaln M., Nishiyama R. et al. // Arch. Pathol. Lab. Med. - 19S9. - Vol. 113. - P. 1035-1041.</mixed-citation><mixed-citation xml:lang="en">Hamburger J. I., Husaln M., Nishiyama R. et al. // Arch. Pathol. Lab. Med. - 19S9. - Vol. 113. - P. 1035-1041.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hung W. // Horm. Res. - 1999. - Vol. 52. - P. 15-18.</mixed-citation><mixed-citation xml:lang="en">Hung W. // Horm. Res. - 1999. - Vol. 52. - P. 15-18.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Jaksic J., Dumic M., Filipovic B. // Arch. Dis. Child. - 1994. -Vol. 70, N 2. - P. 103-106.</mixed-citation><mixed-citation xml:lang="en">Jaksic J., Dumic M., Filipovic B. // Arch. Dis. Child. - 1994. -Vol. 70, N 2. - P. 103-106.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Khurana K. K., Labrador E., Izquierdo R. // Thyroid. - 1999. -Vol. 19. N 4. - P. 383-386.</mixed-citation><mixed-citation xml:lang="en">Khurana K. K., Labrador E., Izquierdo R. // Thyroid. - 1999. -Vol. 19. N 4. - P. 383-386.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lafferty A., Batch J. //J. Pediatr. Endocrinol. Metab. - 1997. -Vol. 10. - P. 479-486.</mixed-citation><mixed-citation xml:lang="en">Lafferty A., Batch J. //J. Pediatr. Endocrinol. Metab. - 1997. -Vol. 10. - P. 479-486.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lugo-Vicente H., Ortiz V. N., Irizarry H. // J. Pediatr. Surg. - 1998. - Vol. 33, N 8. - P. 1302-1305.</mixed-citation><mixed-citation xml:lang="en">Lugo-Vicente H., Ortiz V. N., Irizarry H. // J. Pediatr. Surg. - 1998. - Vol. 33, N 8. - P. 1302-1305.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Millman В., Pellitteri P. K. // Otolaryngol. Head Neck Surg. - 1997. - Vol. 116. - P. 604.-609.</mixed-citation><mixed-citation xml:lang="en">Millman В., Pellitteri P. K. // Otolaryngol. Head Neck Surg. - 1997. - Vol. 116. - P. 604.-609.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Niedziela M., Korman E., Breborowicz D. et al. // Pediatr. Blood Cancer. - 2004. - Vol. 42. - P. 84-93.</mixed-citation><mixed-citation xml:lang="en">Niedziela M., Korman E., Breborowicz D. et al. // Pediatr. Blood Cancer. - 2004. - Vol. 42. - P. 84-93.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Niedziela M. // Endocrine-Relat. Cancer. - 2006. - Vol. 13. - P. 427-453.</mixed-citation><mixed-citation xml:lang="en">Niedziela M. // Endocrine-Relat. Cancer. - 2006. - Vol. 13. - P. 427-453.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Pacini F., Shlumberger M., Dralle H. et al. // Eur. J. Endocrinol. - 2006. - Vol. 154. - P. 787-803.</mixed-citation><mixed-citation xml:lang="en">Pacini F., Shlumberger M., Dralle H. et al. // Eur. J. Endocrinol. - 2006. - Vol. 154. - P. 787-803.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Raab S. S., Silvcrmann J. F., Elsheikh Т. M. et al. // Pediatrics. - 1995. - Vol. 95. - P. 46-49.</mixed-citation><mixed-citation xml:lang="en">Raab S. S., Silvcrmann J. F., Elsheikh Т. M. et al. // Pediatrics. - 1995. - Vol. 95. - P. 46-49.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wang C, Crapo M. L. L. // Endocrinol. Metab. Clin. Am. - 1997. - Vol. 26. - P. 189-218.</mixed-citation><mixed-citation xml:lang="en">Wang C, Crapo M. L. L. // Endocrinol. Metab. Clin. Am. - 1997. - Vol. 26. - P. 189-218.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
