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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl199743245-53</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11181</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Вазоактивные эффекты половых гормонов</article-title><trans-title-group xml:lang="en"><trans-title>Vasoactive effects of sex hormones</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караченцев</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Karachentsev</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеев</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeev</surname><given-names>P. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p class="a0" style="line-height: normal; background: transparent;"&gt;&lt;span style="font-size: 12.0pt;"&gt;Российский государственный медицинский университет&lt;/span&gt;&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Russian State Medical University&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>&lt;p&gt;Российский государственный медицинский университет&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Russian State Medical University&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>1997</year></pub-date><pub-date pub-type="epub"><day>15</day><month>04</month><year>1997</year></pub-date><volume>43</volume><issue>2</issue><issue-title>ТОМ 43, №2 (1997)</issue-title><fpage>45</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Караченцев А.Н., Сергеев П.В., 1997</copyright-statement><copyright-year>1997</copyright-year><copyright-holder xml:lang="ru">Караченцев А.Н., Сергеев П.В.</copyright-holder><copyright-holder xml:lang="en">Karachentsev A.N., Sergeev P.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11181">https://www.probl-endojournals.ru/jour/article/view/11181</self-uri><abstract><p>Обширный экспериментальный и клинический материал, приводимый в современной научной литературе, свидетельствует о влиянии половых гормонов на сердечно-сосудистую систему и необходимости учета изменений в ее деятельности при терапии препаратами, содержащими данные биологически активные вещества [3, 5, 7, 71]. Наряду с опосредованными через структуры центральной нервной системы и циркулирующие в кровеносной системе многочисленные соединения геномные вазоактивные эффекты всех стероидных соединений, включая половые гормоны, могут реализовываться благодаря прямому действию на сосудистую стенку [55, 66, 71, 75].</p></abstract><trans-abstract xml:lang="en"><p>Extensive experimental and clinical material cited in the modern scientific literature indicates the effect of sex hormones on the cardiovascular system and the need to take into account changes in its activity during therapy with drugs containing these biologically active substances [3, 5, 7, 71]. Along with the numerous compounds mediated through the structures of the central nervous system and circulating in the circulatory system, the genomic vasoactive effects of all steroid compounds, including sex hormones, can be realized due to the direct effect on the vascular wall [55, 66, 71, 75].</p></trans-abstract><kwd-group xml:lang="ru"><kwd>половые гормоны</kwd><kwd>концепция вазоактивности</kwd><kwd>эстрогены и гестагены</kwd></kwd-group><kwd-group xml:lang="en"><kwd>sex hormones</kwd><kwd>vasoactivity concept</kwd><kwd>estrogens and progestogens</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Грацианский Н. А. // Клин, фармакол. и тер. — 1994. — № 3. - С. 30-39.</mixed-citation><mixed-citation xml:lang="en">Грацианский Н. 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