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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl199844247-51</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11246</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Эпидемиология инсулинзависимого сахарного диабета</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiology of insulin-dependent diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дедов</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dedov</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сунцов</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Suntsov</surname><given-names>Yu. I.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудрякова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryakova</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыжкова</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryzhkova</surname><given-names>S. G.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Эндокринологический научный центр РАМН&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinology Research Center RAMS&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>1998</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>1998</year></pub-date><volume>44</volume><issue>2</issue><fpage>47</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дедов И.И., Сунцов Ю.И., Кудрякова С.В., Рыжкова С.Г., 1998</copyright-statement><copyright-year>1998</copyright-year><copyright-holder xml:lang="ru">Дедов И.И., Сунцов Ю.И., Кудрякова С.В., Рыжкова С.Г.</copyright-holder><copyright-holder xml:lang="en">Dedov I.I., Suntsov Y.I., Kudryakova S.V., Ryzhkova S.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11246">https://www.probl-endojournals.ru/jour/article/view/11246</self-uri><abstract><p>Эпидемиология сахарного диабета (СД) — раздел диабетологии, включающий в себя изучение основных закономерностей формирования эпидемиологической ситуации и эпидемиологических условий в отношении этого заболевания, а также экологических, социальных и биологических факторов, определяющих динамику его основных эпидемиологических характеристик.</p><p>Конечными точками эпидемического процесса являются распространенность случаев болезни, их частота и смертность больных диабетом. Каждая из этих характеристик определяется многими факторами, которые во времени могут изменять свою значимость, приоритетность и даже утрачивать ее.</p><p>Эпидемиологический подход в решении ряда проблем диабетологии основывается на тех же принципах, что и эпидемиология других неинфекционных заболеваний: сердечно-сосудистых, онкологических и некоторых других. Главные из них: объект исследования — население (популяция); изучение заболевания проводится в естественных условиях его развития и течения; в поле зрения исследователя вся совокупность факторов, которые могут ассоциироваться с фактом развития болезни.</p></abstract><trans-abstract xml:lang="en"><p>The epidemiology of diabetes mellitus (DM) is a section of diabetology that includes the study of the basic laws of the formation of the epidemiological situation and the epidemiological conditions in relation to this disease, as well as environmental, social and biological factors that determine the dynamics of its main epidemiological characteristics.</p><p>The end points of the epidemic process are the prevalence of cases of the disease, their frequency and mortality of patients with diabetes. Each of these characteristics is determined by many factors that can change their importance, priority and even lose it over time.</p><p>The epidemiological approach to solving a number of diabetological problems is based on the same principles as the epidemiology of other noncommunicable diseases: cardiovascular, oncological and some others. The main ones: the object of study is the population (population); the study of the disease is carried out in vivo of its development and course; in the researcher’s field of vision, the whole set of factors that can be associated with the fact of the development of the disease.</p><sec><title> </title><p> </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инсулинзависимый сахарный диабет</kwd><kwd>эпидемиология</kwd><kwd>диабетология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>insulin-dependent diabetes mellitus</kwd><kwd>epidemiology</kwd><kwd>diabetology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ajgaonkaar S. А. // Diabetes 1979 / Ed. W. Waldhausl. — Amsterdam, 1980. — P. 819—828.</mixed-citation><mixed-citation xml:lang="en">Ajgaonkaar S. А. // Diabetes 1979 / Ed. W. Waldhausl. — Amsterdam, 1980. — P. 819—828.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bao M. Z., Wang J. X., Dorman J. S., Trucco M. // Lancet. — 1988- Vol. 2. - P. 497-498.</mixed-citation><mixed-citation xml:lang="en">Bao M. Z., Wang J. X., Dorman J. S., Trucco M. // Lancet. — 1988- Vol. 2. - P. 497-498.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bingley P. J., Gale E. A. M. // Brit. med. J. — 1989. — Vol. 298. - P. 558-560.</mixed-citation><mixed-citation xml:lang="en">Bingley P. J., Gale E. A. M. // Brit. med. J. — 1989. — Vol. 298. - P. 558-560.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bruno G., Merletti F., Vuolo A. et al. // Diabet. Care. — 1990. — Vol. 13. - P. 1051-1057.</mixed-citation><mixed-citation xml:lang="en">Bruno G., Merletti F., Vuolo A. et al. // Diabet. Care. — 1990. — Vol. 13. - P. 1051-1057.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Carrasco E., Lopez G., Garcia de los Rios M., Vargas N. // Rev. Soc. Argent. Diabet. — 1992. — Vol. 26, Suppl. — P. 14-15.</mixed-citation><mixed-citation xml:lang="en">Carrasco E., Lopez G., Garcia de los Rios M., Vargas N. // Rev. Soc. Argent. Diabet. — 1992. — Vol. 26, Suppl. — P. 14-15.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chakraborty R., Kamboh M. I., Nwankwo M., Ferrell R. // Amer. J. hum. Genet. — 1992. — Vol. 50. — P. 145—155.</mixed-citation><mixed-citation xml:lang="en">Chakraborty R., Kamboh M. I., Nwankwo M., Ferrell R. // Amer. J. hum. Genet. — 1992. — Vol. 50. — P. 145—155.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Crow Y. J., Alberti K. G. M. M., Parkin J. M. // Brit. med. J. — 1991_ Vol. 303. - P. 158-160.</mixed-citation><mixed-citation xml:lang="en">Crow Y. J., Alberti K. G. M. M., Parkin J. M. // Brit. med. J. — 1991_ Vol. 303. - P. 158-160.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Cudworth A. G., Wolf E., Gorsuch A. N., Festenstein H. // Lancet. - 1979. - Vol. 2. - P. 380-390.</mixed-citation><mixed-citation xml:lang="en">Cudworth A. G., Wolf E., Gorsuch A. N., Festenstein H. // Lancet. - 1979. - Vol. 2. - P. 380-390.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Diabetes Epidemiology Research International Group // Diabetes. - 1988. - Vol. 37. - P. 1113-1119.</mixed-citation><mixed-citation xml:lang="en">Diabetes Epidemiology Research International Group // Diabetes. - 1988. - Vol. 37. - P. 1113-1119.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Diabetes Epidemiology Research International Group // Diabet. Care. - 1989. - Vol. 12. - P. 487-493.</mixed-citation><mixed-citation xml:lang="en">Diabetes Epidemiology Research International Group // Diabet. Care. - 1989. - Vol. 12. - P. 487-493.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Diabetes Epidemiology Research International (DERI) Group // Diabet. Metab. Rev. — 1990. — Vol. 6. — P. 63—69.</mixed-citation><mixed-citation xml:lang="en">Diabetes Epidemiology Research International (DERI) Group // Diabet. Metab. Rev. — 1990. — Vol. 6. — P. 63—69.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Diabetes Epidemiology Research International Study Group // Bull. WHO. - 1990. - Vol. 68. - P. 231-236.</mixed-citation><mixed-citation xml:lang="en">Diabetes Epidemiology Research International Study Group // Bull. WHO. - 1990. - Vol. 68. - P. 231-236.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Diabetes Epidemiology Research International Group // Diabetes. - 1990. - Vol. 39. - P. 858-864.</mixed-citation><mixed-citation xml:lang="en">Diabetes Epidemiology Research International Group // Diabetes. - 1990. - Vol. 39. - P. 858-864.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dorman J. S., LaPorte R. E., Stone R. A., Trucco M. /'/ Proc, natl. Acad. Sci. USA. — 1990. — Vol. 87. — P. 7370—7374.</mixed-citation><mixed-citation xml:lang="en">Dorman J. S., LaPorte R. E., Stone R. A., Trucco M. /'/ Proc, natl. Acad. Sci. USA. — 1990. — Vol. 87. — P. 7370—7374.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Elliott R. B., Pilcher C. // N. Z. med. J. — 1985. — Vol. 87. — P. 922-923.</mixed-citation><mixed-citation xml:lang="en">Elliott R. B., Pilcher C. // N. Z. med. J. — 1985. — Vol. 87. — P. 922-923.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Forrest J. M., Menser M. A., Burgess J. A. // Lancet. — 1988. — Vol. 2. - P. 1-4.</mixed-citation><mixed-citation xml:lang="en">Forrest J. M., Menser M. A., Burgess J. A. // Lancet. — 1988. — Vol. 2. - P. 1-4.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Franco L., Vivolo M. // International Diabetes Federation Congress, 13-th. Satellite Congress on Epidemiology of Diabetes: Abstracts. — Hobart, 1988. — P. 165.</mixed-citation><mixed-citation xml:lang="en">Franco L., Vivolo M. // International Diabetes Federation Congress, 13-th. Satellite Congress on Epidemiology of Diabetes: Abstracts. — Hobart, 1988. — P. 165.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Green A., Gale E. A. M., Patterson С. C. // Lancet. — 1992. — Vol. 339. - P. 905-909.</mixed-citation><mixed-citation xml:lang="en">Green A., Gale E. A. M., Patterson С. C. // Lancet. — 1992. — Vol. 339. - P. 905-909.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Green A., Andersen P. K, Svendsen A. J., Mortensen K. // Dia- betologia. - 1992. - Vol. 35. - P. 178-182.</mixed-citation><mixed-citation xml:lang="en">Green A., Andersen P. K, Svendsen A. J., Mortensen K. // Dia- betologia. - 1992. - Vol. 35. - P. 178-182.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hagglof B., Holmgren G., Wall S. // Hum. Hered. 1982. — Vol. 32. - P. 408-417.</mixed-citation><mixed-citation xml:lang="en">Hagglof B., Holmgren G., Wall S. // Hum. Hered. 1982. — Vol. 32. - P. 408-417.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hearnshaw J. R. // Diabetes 1985 / Eds M. Serrano-Rios, P. J. Lefebvre. — Amsterdam, 1986. — P. 31—42.</mixed-citation><mixed-citation xml:lang="en">Hearnshaw J. R. // Diabetes 1985 / Eds M. Serrano-Rios, P. J. Lefebvre. — Amsterdam, 1986. — P. 31—42.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Helgason T., Danielsen R., Thorddon A. // Diabetologia. — Vol. 35. - P. 880-883.</mixed-citation><mixed-citation xml:lang="en">Helgason T., Danielsen R., Thorddon A. // Diabetologia. — Vol. 35. - P. 880-883.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hours M., Febry J., Siemiatycki J., Francois R. // Rev. Epidemiol. Sante Publ. — 1984. — Vol. 32. — P. 107—112.</mixed-citation><mixed-citation xml:lang="en">Hours M., Febry J., Siemiatycki J., Francois R. // Rev. Epidemiol. Sante Publ. — 1984. — Vol. 32. — P. 107—112.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Joner G., Sovik O. // Diabetologia. — 1989. — Vol. 32. — P. 79-83.</mixed-citation><mixed-citation xml:lang="en">Joner G., Sovik O. // Diabetologia. — 1989. — Vol. 32. — P. 79-83.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly H. A., Byrne G. C. // Diabet. Care. — 1992. — Vol. 15. — P. 515-517.</mixed-citation><mixed-citation xml:lang="en">Kelly H. A., Byrne G. C. // Diabet. Care. — 1992. — Vol. 15. — P. 515-517.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Khalil I., d’Auriol L., Gober M. et al. // J. clin. Invest. — 1990. — Vol. 85. - P. 1315-1319.</mixed-citation><mixed-citation xml:lang="en">Khalil I., d’Auriol L., Gober M. et al. // J. clin. Invest. — 1990. — Vol. 85. - P. 1315-1319.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Laakso M., Pyorala K. // Diabet. Care. — 1985. — Vol. 8. — P. 114-117.</mixed-citation><mixed-citation xml:lang="en">Laakso M., Pyorala K. // Diabet. Care. — 1985. — Vol. 8. — P. 114-117.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuura N., Fukushima N., Fujita H. et al. // Tohoku J. exp. Med. - 1983. — Vol. 141, Suppl. - P. 181-189.</mixed-citation><mixed-citation xml:lang="en">Matsuura N., Fukushima N., Fujita H. et al. // Tohoku J. exp. Med. - 1983. — Vol. 141, Suppl. - P. 181-189.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Meltron L., Palumbo P., Chu C. // Diabet. Care. — 1983. — Vol. 6. - P. 75-86.</mixed-citation><mixed-citation xml:lang="en">Meltron L., Palumbo P., Chu C. // Diabet. Care. — 1983. — Vol. 6. - P. 75-86.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Metcalfe M. A., Baum J. D. // Brit. med. J. — 1991. — Vol. 302. - P. 443-447.</mixed-citation><mixed-citation xml:lang="en">Metcalfe M. A., Baum J. D. // Brit. med. J. — 1991. — Vol. 302. - P. 443-447.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Nystrom L., Dahlquist G., Rewers M., Wall S. // Int. J. Epidemiol. — 1990. — Vol. 19. — P. 141 — 146.</mixed-citation><mixed-citation xml:lang="en">Nystrom L., Dahlquist G., Rewers M., Wall S. // Int. J. Epidemiol. — 1990. — Vol. 19. — P. 141 — 146.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Reitnauer P. J., Go R. С. P., Acton R. T. et al. // Diabetes. — 1982. - Vol. 31. - P. 532-537.</mixed-citation><mixed-citation xml:lang="en">Reitnauer P. J., Go R. С. P., Acton R. T. et al. // Diabetes. — 1982. - Vol. 31. - P. 532-537.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Reunanen A., Akerblom H. К, Kaar M. L. // Acta paediatr. scand. — 1982. — Vol. 71. - P. 893—899.</mixed-citation><mixed-citation xml:lang="en">Reunanen A., Akerblom H. К, Kaar M. L. // Acta paediatr. scand. — 1982. — Vol. 71. - P. 893—899.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Rewers M., LaPorte R. E., King H., Tuomilehto J. // World Health Stat. - 1988. - Vol. 41. - P. 179.</mixed-citation><mixed-citation xml:lang="en">Rewers M., LaPorte R. E., King H., Tuomilehto J. // World Health Stat. - 1988. - Vol. 41. - P. 179.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Rewers M., Stone R. A., LaPorte R. E. et al. // Amer. J. Epidemiol. - 1989. - Vol. 129. - P. 569-581.</mixed-citation><mixed-citation xml:lang="en">Rewers M., Stone R. A., LaPorte R. E. et al. // Amer. J. Epidemiol. - 1989. - Vol. 129. - P. 569-581.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rotter J. I., Landaw E. M. // Clin. Genet. — 1984. — Vol. 26 — P. 529-542.</mixed-citation><mixed-citation xml:lang="en">Rotter J. I., Landaw E. M. // Clin. Genet. — 1984. — Vol. 26 — P. 529-542.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Schranz A. G., Prikatsky И // Diabet. Med. — 1989. — Vol. 6. — P. 228-231.</mixed-citation><mixed-citation xml:lang="en">Schranz A. G., Prikatsky И // Diabet. Med. — 1989. — Vol. 6. — P. 228-231.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Seclen S., Rojas M. L, Valdivia H. et al. // IDF Congress Satellite Symposium Epidemiology of Diabetes and its Complications, 14-th: Abstracts. — Williamsburg, 1991. — P. 211.</mixed-citation><mixed-citation xml:lang="en">Seclen S., Rojas M. L, Valdivia H. et al. // IDF Congress Satellite Symposium Epidemiology of Diabetes and its Complications, 14-th: Abstracts. — Williamsburg, 1991. — P. 211.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shubnikov E., Podar T., Tuomilehto J., Nikitin Y. // Diabet. Care. - 1992. - Vol. 15. - P. 915-917.</mixed-citation><mixed-citation xml:lang="en">Shubnikov E., Podar T., Tuomilehto J., Nikitin Y. // Diabet. Care. - 1992. - Vol. 15. - P. 915-917.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Siemiatycki J., Colle E., Aubert D. et al. // Amer. J. Epidemiol. — 1986. - Vol. 124. - P. 545-560.</mixed-citation><mixed-citation xml:lang="en">Siemiatycki J., Colle E., Aubert D. et al. // Amer. J. Epidemiol. — 1986. - Vol. 124. - P. 545-560.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Songini M. /I Medicographia. — 1992. — Vol. 13. — P. 10—13.</mixed-citation><mixed-citation xml:lang="en">Songini M. /I Medicographia. — 1992. — Vol. 13. — P. 10—13.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Todd J. A., Bell J. I., McDevitt H. O. // Nature. — 1987. — Vol. 329. - P. 599-604.</mixed-citation><mixed-citation xml:lang="en">Todd J. A., Bell J. I., McDevitt H. O. // Nature. — 1987. — Vol. 329. - P. 599-604.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Tull E. S., Roseman J. M., Christian C. L. E. // Diabet. Care. —- Vol. 14. - P. 558-564.</mixed-citation><mixed-citation xml:lang="en">Tull E. S., Roseman J. M., Christian C. L. E. // Diabet. Care. —- Vol. 14. - P. 558-564.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tuomilehto J., Lounamaa R., Tuomilehto-Wolf E. et al. // Diabetologia. - 1992. - Vol. 35. - P. 70-76.</mixed-citation><mixed-citation xml:lang="en">Tuomilehto J., Lounamaa R., Tuomilehto-Wolf E. et al. // Diabetologia. - 1992. - Vol. 35. - P. 70-76.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Tuomilehto J., Podar T, Brigis G. et al. // Int. J. Epidemiol. —- Vol. 21. - P. 518-527.</mixed-citation><mixed-citation xml:lang="en">Tuomilehto J., Podar T, Brigis G. et al. // Int. J. Epidemiol. —- Vol. 21. - P. 518-527.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Tuomilehto-Wolf E., Tuomilehto J. // Diabetes. — 1990. — Vol. 39, Suppl. 21A. - P. 81.</mixed-citation><mixed-citation xml:lang="en">Tuomilehto-Wolf E., Tuomilehto J. // Diabetes. — 1990. — Vol. 39, Suppl. 21A. - P. 81.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Tuomilehto-Wolf E., Tuomilehto J. // Ann. Med. — 1991. — Vol. 23. - P. 481-488.</mixed-citation><mixed-citation xml:lang="en">Tuomilehto-Wolf E., Tuomilehto J. // Ann. Med. — 1991. — Vol. 23. - P. 481-488.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Wagenknecht L., Roseman M., Allexandex W. // Diabetes. — 1989. - Vol. 38. - P. 629-633.</mixed-citation><mixed-citation xml:lang="en">Wagenknecht L., Roseman M., Allexandex W. // Diabetes. — 1989. - Vol. 38. - P. 629-633.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Wagenknecht L. E., Roseman J. M., Herman W. H. // Amer. J. Epidemiol. - 1991. - Vol. 133. - P. 1024-1031.</mixed-citation><mixed-citation xml:lang="en">Wagenknecht L. E., Roseman J. M., Herman W. H. // Amer. J. Epidemiol. - 1991. - Vol. 133. - P. 1024-1031.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">WHO DIAMOND Project. WHO Multinational project for childhood diabetes // Diabet. Care. — 1990. — Vol. 13. — P. 1062-1068. t</mixed-citation><mixed-citation xml:lang="en">WHO DIAMOND Project. WHO Multinational project for childhood diabetes // Diabet. Care. — 1990. — Vol. 13. — P. 1062-1068. t</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf E., Spencer К. M., Cudworth A. G. // Diabetologia. — 1984. - Vol. 24. - P. 224-230.</mixed-citation><mixed-citation xml:lang="en">Wolf E., Spencer К. M., Cudworth A. G. // Diabetologia. — 1984. - Vol. 24. - P. 224-230.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Yoon J.-W., Austin M., Ondera T, Notkins A. L. // N. Engl. J. Med. - 1979. - Vol. 300. - P. 1173-1179.</mixed-citation><mixed-citation xml:lang="en">Yoon J.-W., Austin M., Ondera T, Notkins A. L. // N. Engl. J. Med. - 1979. - Vol. 300. - P. 1173-1179.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
