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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl11286</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11286</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Опыт применения сиофора (метформина) у больных с нарушением углеводного и жирового обмена</article-title><trans-title-group xml:lang="en"><trans-title>Siofor (metformine) therapy of patients with disorders of carbohydrate and fatty metabolism</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>T. P.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Московский медицинский стоматологический институт&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Moscow State University of Medicine and Dentistry&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2001</year></pub-date><pub-date pub-type="epub"><day>15</day><month>02</month><year>2001</year></pub-date><volume>47</volume><issue>1</issue><issue-title>ТОМ 47, №1 (2001)</issue-title><fpage>9</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Морозова Т.П., 2001</copyright-statement><copyright-year>2001</copyright-year><copyright-holder xml:lang="ru">Морозова Т.П.</copyright-holder><copyright-holder xml:lang="en">Morozova T.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11286">https://www.probl-endojournals.ru/jour/article/view/11286</self-uri><abstract><p>Сиофор в сочетании с производными сульфонилмочевины у больных сахарным диабетом типа 2 с вторичной резистентностью позволяет добиться стойкой компенсации заболевания и избежать необходимости применения инсулинотерапии. У больных с ожирением и нарушенной толерантностью к глюкозе сиофор способствует снижению массы тела, не изменяя показателей стандартного глюкозотолерантного теста.</p></abstract><trans-abstract xml:lang="en"><p>Siofor in combination with sulfanylurea derivatives led to stable compensation making insulin therapy unnecessary in patients with type II diabetes mellitus with secondary resistance to treatment. In obese patients with impaired glucose tolerance siofor promoted body weight loss without changing the parameters of standard glucose tolerance test.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сиофор</kwd><kwd>нарушение углеводного и жирового обмена</kwd></kwd-group><kwd-group xml:lang="en"><kwd>siofor</kwd><kwd>disorders of carbohydrate and fatty metabolism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey С. J., Mynett К. J., Page Т. // Br. J. 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