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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl11579</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11579</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Материалы конгресса</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Proceedings of the Congress</subject></subj-group></article-categories><title-group><article-title>Функциональная бивалентность эстрогенов и феномен переключения эстрогенного эффекта: роль в развитии возрастной патологии</article-title><trans-title-group xml:lang="en"><trans-title>Functional bivalence of estrogens and estrogen effect switching over: role in the development of age-associated diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Берштейн</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bershtein</surname><given-names>L. M.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цырлина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsyrlina</surname><given-names>Ye. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порошина</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Poroshina</surname><given-names>T. Ye.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гамаюнова</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Gamayunova</surname><given-names>V. B.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilyev</surname><given-names>D. A.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коваленко</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalenko</surname><given-names>I. G.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бычкова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bychkova</surname><given-names>N. V</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;НИИ онкологии им. проф. Н. Н. Петрова Минздрава РФ&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>15</day><month>08</month><year>2002</year></pub-date><volume>48</volume><issue>4</issue><issue-title>ТОМ 48, №4 (2002)</issue-title><fpage>49</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Берштейн Л.М., Цырлина Е.В., Порошина Т.Е., Гамаюнова В.Б., Васильев Д.А., Коваленко И.Г., Бычкова Н.В., 2002</copyright-statement><copyright-year>2002</copyright-year><copyright-holder xml:lang="ru">Берштейн Л.М., Цырлина Е.В., Порошина Т.Е., Гамаюнова В.Б., Васильев Д.А., Коваленко И.Г., Бычкова Н.В.</copyright-holder><copyright-holder xml:lang="en">Bershtein L.M., Tsyrlina Y.V., Poroshina T.Y., Gamayunova V.B., Vasilyev D.A., Kovalenko I.G., Bychkova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11579">https://www.probl-endojournals.ru/jour/article/view/11579</self-uri><abstract><p>Статья посвящена функциональной бивалентности эстрогенов и феномену переключения эстрогенного эффекта.</p></abstract><trans-abstract xml:lang="en"><p>The article is devoted to functional bivalence of estrogens and estrogen effect switching over.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>функциональная бивалентность эстрогенов</kwd><kwd>феномен переключения эстрогенного эффекта</kwd><kwd>патология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>functional bivalence of estrogens</kwd><kwd>estrogen effect switching over</kwd><kwd>diseases</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Functional bivalence of estrogens; estrogen effect switching over; diseases</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Берштейн Л. 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