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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl11613</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11613</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Инсулиносекреция и инсулинорезистентность: две стороны одной медали</article-title><trans-title-group xml:lang="en"><trans-title>Insulin secretion and insulin resistance: two sides of one medal</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аметов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ametov</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Российская медицинская академия последипломного образования; Центр ВОЗ по обучению и информатике в области диабета&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Russian Medical Academy of Postgraduate Education; World Health Organization Center for Diabetes Education and Informatics&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2002</year></pub-date><volume>48</volume><issue>3</issue><fpage>31</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аметов А.С., 2002</copyright-statement><copyright-year>2002</copyright-year><copyright-holder xml:lang="ru">Аметов А.С.</copyright-holder><copyright-holder xml:lang="en">Ametov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11613">https://www.probl-endojournals.ru/jour/article/view/11613</self-uri><abstract><p>Сахарный диабет представляет собой серьезную медико-социальную проблему, что обусловлено его высокой распространенностью, сохраняющейся тенденцией к росту числа больных, хроническим течением, определяющим кумулятивный характер заболевания, высокой инвалидизацией больных и необходимостью создания системы специализированной помощи.</p></abstract><trans-abstract xml:lang="en"><p>Diabetes mellitus is a serious medical and social problem, which is due to its high prevalence, a continuing upward trend in the number of patients, a chronic course that determines the cumulative nature of the disease, high disability of patients, and the need to create a specialized care system.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инсулиносекреция</kwd><kwd>инсулинорезистентность</kwd><kwd>cахарный диабет</kwd></kwd-group><kwd-group xml:lang="en"><kwd>insulin secretion</kwd><kwd>insulin resistance</kwd><kwd>diabetes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bernard-Kargar С. // Diabetes. - 2001. - Vol. 50. - Suppl. 1. - P. 30.</mixed-citation><mixed-citation xml:lang="en">Bernard-Kargar С. // Diabetes. - 2001. - Vol. 50. - Suppl. 1. - P. 30.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bonner-Weir S. // Ibid. - P. 20.</mixed-citation><mixed-citation xml:lang="en">Bonner-Weir S. // Ibid. - P. 20.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cerasi E. // Metabolism. - 2000. - Vol. 49, N 10. - Suppl. 1. - P. 1-3.</mixed-citation><mixed-citation xml:lang="en">Cerasi E. // Metabolism. - 2000. - Vol. 49, N 10. - Suppl. 1. - P. 1-3.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">De Fronzo R. // Ann. Intern. Med. - 1999. - Vol. 131. - P. 281-303.</mixed-citation><mixed-citation xml:lang="en">De Fronzo R. // Ann. Intern. Med. - 1999. - Vol. 131. - P. 281-303.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fajans S. // Diabet. Metab. Rev. - 1989. - Vol. 5. - P. 579-606.</mixed-citation><mixed-citation xml:lang="en">Fajans S. // Diabet. Metab. Rev. - 1989. - Vol. 5. - P. 579-606.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hotamisligil G. // Exp. Clin. Endocr. - 1999. - Vol. 107. - P. 110-125.</mixed-citation><mixed-citation xml:lang="en">Hotamisligil G. // Exp. Clin. Endocr. - 1999. - Vol. 107. - P. 110-125.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kloppel G. et al. // Surv. Synth. Pathol. Res. - 1985. - Vol. 4. - P. 110-125.</mixed-citation><mixed-citation xml:lang="en">Kloppel G. et al. // Surv. Synth. Pathol. Res. - 1985. - Vol. 4. - P. 110-125.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lang et al. // N. Engl. J. Med. - 1979. - Vol. 301. - P. 1023. Cit. by: Ellenberg M., Rifkin H. Diabetes Mellitus. Theory and Practice. - 3-rd Ed. - 1983.</mixed-citation><mixed-citation xml:lang="en">Lang et al. // N. Engl. J. Med. - 1979. - Vol. 301. - P. 1023. Cit. by: Ellenberg M., Rifkin H. Diabetes Mellitus. Theory and Practice. - 3-rd Ed. - 1983.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Malaisse W. // Diabetologia. - 2001. - Vol. 4. - P. 44.</mixed-citation><mixed-citation xml:lang="en">Malaisse W. // Diabetologia. - 2001. - Vol. 4. - P. 44.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Olefsky J. // Curr. Option Endocrinol. Diabet. - 1995. - Vol. 2. - P. 290-299.</mixed-citation><mixed-citation xml:lang="en">Olefsky J. // Curr. Option Endocrinol. Diabet. - 1995. - Vol. 2. - P. 290-299.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Owens D., McDougall A. // Diabet., Obes., Metab. - 2000. - Suppl. 2. - P. 43-48.</mixed-citation><mixed-citation xml:lang="en">Owens D., McDougall A. // Diabet., Obes., Metab. - 2000. - Suppl. 2. - P. 43-48.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Polonsky K. // N. Engl. J. Med. - 1988. - Vol. 318. - P. 1231-1239.</mixed-citation><mixed-citation xml:lang="en">Polonsky K. // N. Engl. J. Med. - 1988. - Vol. 318. - P. 1231-1239.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Polonsky K. // Diabetes. - 1994. - Vol. 43. - P. 871-877.</mixed-citation><mixed-citation xml:lang="en">Polonsky K. // Diabetes. - 1994. - Vol. 43. - P. 871-877.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven G. M. // J. Clin. Endocrinol. Metab. - 1993. - Vol. 76. - P. 44-48.</mixed-citation><mixed-citation xml:lang="en">Reaven G. M. // J. Clin. Endocrinol. Metab. - 1993. - Vol. 76. - P. 44-48.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rifkin H. Diabetes Mellitus. Theory and Practice. - 4-th Ed. - 1992.</mixed-citation><mixed-citation xml:lang="en">Rifkin H. Diabetes Mellitus. Theory and Practice. - 4-th Ed. - 1992.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Slama G. // Int. J. Clin. Pract. - 2000. - Suppl. 112. - P. 9-13.</mixed-citation><mixed-citation xml:lang="en">Slama G. // Int. J. Clin. Pract. - 2000. - Suppl. 112. - P. 9-13.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Stagner et al. // J. Clin. Invest. - 1980. - Vol. 65. - P. 939. Cit. by: Ellenberg M., Rifkin H. Diabetes Mellitus. Theory and Practice. - 3-rd Ed. - 1983.</mixed-citation><mixed-citation xml:lang="en">Stagner et al. // J. Clin. Invest. - 1980. - Vol. 65. - P. 939. Cit. by: Ellenberg M., Rifkin H. Diabetes Mellitus. Theory and Practice. - 3-rd Ed. - 1983.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor S. // Diabetes. - 1992. - Vol. 41. - P. 1473-1490.</mixed-citation><mixed-citation xml:lang="en">Taylor S. // Diabetes. - 1992. - Vol. 41. - P. 1473-1490.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Turner R. et al. // UKPDS, 49. - 1999. - Vol. 281. - P. 2005-2012.</mixed-citation><mixed-citation xml:lang="en">Turner R. et al. // UKPDS, 49. - 1999. - Vol. 281. - P. 2005-2012.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
