<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl11716</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11716</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Оценка состояния рострегулирующей системы и применение рекомбинантного гормона роста (генотропина) у детей с ревматическими заболеваниями и нарушением роста на фоне длительной глюкокортикостероидной терапии</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the growth-regulating system and use the recombinant growth hormone (genotropin) in children with rheumatic diseases and growth impairments on long-term glucocorticosteroid therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharova</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волеводз</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Volevodz</surname><given-names>N. N.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петеркова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Peterkova</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;ММА им. И. М. Сеченова; Эндокринологический научный центр РАМН&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;I. M. Sechenov MMA; Endocrinology Research Center of RAMS&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2002</year></pub-date><volume>48</volume><issue>6</issue><issue-title>ТОМ 48, №6 (2002)</issue-title><fpage>30</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарова А.А., Волеводз Н.Н., Петеркова В.А., 2002</copyright-statement><copyright-year>2002</copyright-year><copyright-holder xml:lang="ru">Шарова А.А., Волеводз Н.Н., Петеркова В.А.</copyright-holder><copyright-holder xml:lang="en">Sharova A.A., Volevodz N.N., Peterkova V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11716">https://www.probl-endojournals.ru/jour/article/view/11716</self-uri><abstract><p>В статье представлены результаты исследования состояния рострегулирующей системы (СТГ-инсулиноподобный фактор роста 1-периферические ткани) у 39 детей с ревматическими заболеваниями, получавших длительную непрерывную глюкокортикостероидную терапию. Из них 6 пациентов получали рекомбинантный гормон роста (рГР) (генотропин) для коррекции стероидной задержки роста. Терапия рГР в течение 12 мес позволила не только добиться ускорения темпов роста, но и способствовала уменьшению проявлений медикаментозного гиперкортицизма, не оказывая значимого влияния на течение основного заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents the results of an investigation of the growth - regulating system (STH - insulin-like growth factor 1 - peripheral tissues) in 39 children with rheumatic diseases on longterm continuous glucocorticosteroid therapy. Of them, 6 patients received recombinant growth hormone (R-GH) (Genotropin) for correction of steroidal growth retardation. Twelve-month r-GH therapy made it possible not only to accelerate growth rates, but contributed to diminished manifestations of drug-induced hypercorticism without exerting a significant impact in the course of the underlying disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>генотропин</kwd><kwd>нарушение роста</kwd><kwd>глюкокортикостероидная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>genotropin</kwd><kwd>growth impairments</kwd><kwd>glucocorticosteroid therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И. И., Тюльпанов АН., Петеркова В. А. Соматотропная недостаточность. - М., 1998. - С. 38-43.</mixed-citation><mixed-citation xml:lang="en">Дедов И. И., Тюльпанов АН., Петеркова В. А. Соматотропная недостаточность. - М., 1998. - С. 38-43.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Насонова В. А., Астапенко М. Г. Клиническая ревматология: Руководство для врачей. - М., 1989. - С. 142-143.</mixed-citation><mixed-citation xml:lang="en">Насонова В. А., Астапенко М. Г. Клиническая ревматология: Руководство для врачей. - М., 1989. - С. 142-143.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Розен В. Б. // Основы эндокринологии. - 3-е изд. - М., 1994. - С. 241-257.</mixed-citation><mixed-citation xml:lang="en">Розен В. Б. // Основы эндокринологии. - 3-е изд. - М., 1994. - С. 241-257.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Таннер Дж. // Биология человека / Под ред. Дж. Харрисона и др.: Пер. с англ. - М., 1979. - С. 306-471.</mixed-citation><mixed-citation xml:lang="en">Таннер Дж. // Биология человека / Под ред. Дж. Харрисона и др.: Пер. с англ. - М., 1979. - С. 306-471.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Allen D. В. // Endocrinol. Metab. Clin. N. Am. - 1996. - Vol. 25, N 3. - P. 699-717.</mixed-citation><mixed-citation xml:lang="en">Allen D. В. // Endocrinol. Metab. Clin. N. Am. - 1996. - Vol. 25, N 3. - P. 699-717.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Allen D. B. // Endocrinologist. - 1998. - Vol. 8, N 1. - P. 21-30.</mixed-citation><mixed-citation xml:lang="en">Allen D. B. // Endocrinologist. - 1998. - Vol. 8, N 1. - P. 21-30.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Allen D. B., Julius J. R., Breen T. J., Attie К. M. // J. Clin. Endocrinol. Metab. - 1998. - Vol. 83. - P. 2824-2829.</mixed-citation><mixed-citation xml:lang="en">Allen D. B., Julius J. R., Breen T. J., Attie К. M. // J. Clin. Endocrinol. Metab. - 1998. - Vol. 83. - P. 2824-2829.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bechtold S., Rippeiger P., Miihlbayer D. et al. // Ibid. - 2001. - Vol. 86, N 12. - P. 5737-5744.</mixed-citation><mixed-citation xml:lang="en">Bechtold S., Rippeiger P., Miihlbayer D. et al. // Ibid. - 2001. - Vol. 86, N 12. - P. 5737-5744.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Boguszewzki M. C. S., Figueiredo В C., Boguszewzki C. L. et al. I/ GH and Growth Factors in Endocrinology and Metabolism: Programme and Poster Abstracts of the 25-th International Symposium. - Istambul, 1998. - P. 122.</mixed-citation><mixed-citation xml:lang="en">Boguszewzki M. C. S., Figueiredo В C., Boguszewzki C. L. et al. I/ GH and Growth Factors in Endocrinology and Metabolism: Programme and Poster Abstracts of the 25-th International Symposium. - Istambul, 1998. - P. 122.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bowers C. Y. // J. Pediatr. Endocrinol. - 1993. - Vol. 6, N 1.</mixed-citation><mixed-citation xml:lang="en">Bowers C. Y. // J. Pediatr. Endocrinol. - 1993. - Vol. 6, N 1.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
