problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl11749problendo-11749Research ArticleОбзорыReviewsСовременные представления о молекулярных механизмах действия производных сульфонилмочевины на КАТФ-каналыModern concepts on the molecular mechanisms of sulfonylurea effect on KITP channelsАшкрофтФ. М.AshcroftF. М.probl@endojournals.ruРейманнФ.ReimannF.probl@endojournals.ru<p>Оксфордский университет</p>Великобритания<p>Oxford University</p>United Kingdom200115122001476ТОМ 47, №6 (2001)4247Copyright &#x00A9; Ашкрофт Ф.М., Рейманн Ф., 20012001Ашкрофт Ф.М., Рейманн Ф.Ashcroft F.М., Reimann F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/11749

Статья посвящена обзору современные представления о молекулярных механизмах действия производных сульфонилмочевины на катф-каналы.

The article is devoted to the review of the modern concepts on the molecular mechanisms of sulfonylurea effect on KITP channels.

представлениямолекулярные механизмысульфонилмочевинаКАТФ-каналыconceptsmolecular mechanismssulfonylureaKITP channelsReferencesAshcroft FM, Ashcroft SJH. The sulphonylurea receptor. Biochim Biophys Acta. 1992; 1175:45-59.Ashcroft FM, Ashcroft SJH. The sulphonylurea receptor. Biochim Biophys Acta. 1992; 1175:45-59.Ashcroft FM, Gribble FM. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia. 1999; 42:903-919.Ashcroft FM, Gribble FM. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia. 1999; 42:903-919.Ashcroft FM, Rosman P. Electrophysiology of the pancreatic b-cell. Prog Biophys Molec Biol. 1989; 54:87-143.Ashcroft FM, Rosman P. Electrophysiology of the pancreatic b-cell. Prog Biophys Molec Biol. 1989; 54:87-143.Cook DL, Hales CN. Intracellular ATP directly blocks K+ channels in pancreatic b-cells. Nature. 1984; 311:271-273.Cook DL, Hales CN. Intracellular ATP directly blocks K+ channels in pancreatic b-cells. Nature. 1984; 311:271-273.Kakei M, Kelly RP, Ashcroft SJH, Ashcroft FM. The ATP- sensitivity of K+ channels in rat pancreatic b-cells is modulated by ADP. FEBS Lett. 1986; 208:63-66.Kakei M, Kelly RP, Ashcroft SJH, Ashcroft FM. The ATP- sensitivity of K+ channels in rat pancreatic b-cells is modulated by ADP. FEBS Lett. 1986; 208:63-66.Thomas PM, Cote GJ, Wohllk N, et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science. 1995; 268:426-429.Thomas PM, Cote GJ, Wohllk N, et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science. 1995; 268:426-429.Babenko AP, Aguilar-Bryan L, Bryan J. A view of sur/ KIR6.X, KATP channels. Annu Rev Physiol. 1998; 60:667-687.Babenko AP, Aguilar-Bryan L, Bryan J. A view of sur/ KIR6.X, KATP channels. Annu Rev Physiol. 1998; 60:667-687.Randle PJ. Glucokinase and candidate gene for type 2 (non- insulin-dependent) diabetes mellitus. Diabetologia. 1993; 36:269-275.Randle PJ. Glucokinase and candidate gene for type 2 (non- insulin-dependent) diabetes mellitus. Diabetologia. 1993; 36:269-275.Trube G, Rorsman P, Ohno-Shosaku T. Opposite effects of tolbutamide and diazoxide on ATP-dependcnt K+ channel in pancreatic b-cells. PflRgers Arch. 1986; 407:493-499.Trube G, Rorsman P, Ohno-Shosaku T. Opposite effects of tolbutamide and diazoxide on ATP-dependcnt K+ channel in pancreatic b-cells. PflRgers Arch. 1986; 407:493-499.Aguilar-Bryan L, Nichols CG, Wechsler SW, et al. Cloning of the b-cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science. 1995; 268:423-426.Aguilar-Bryan L, Nichols CG, Wechsler SW, et al. Cloning of the b-cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science. 1995; 268:423-426.Edwards G, Weston AH. The pharmacology of ATP-sensitive potassium channels. Annu Rev Pharmacol Toxicol. 1993; 33:597-637.Edwards G, Weston AH. The pharmacology of ATP-sensitive potassium channels. Annu Rev Pharmacol Toxicol. 1993; 33:597-637.Inagaki N, Gonoi T, Clement IV JP, et al. Reconstitution of IKAPT: an inward rectifier subunit plus the sulfonylurea receptor. Science. 1995; 270:1166-1170.Inagaki N, Gonoi T, Clement IV JP, et al. Reconstitution of IKAPT: an inward rectifier subunit plus the sulfonylurea receptor. Science. 1995; 270:1166-1170.Sakura H, AmmKIK C, Smith PA, Gribble FM, Ashcroft FM. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel expressed in pancreatic b-cells, brain, heart abd skeletal muscle. FEBS Lett. 1995; 377:338-344.Sakura H, AmmKIK C, Smith PA, Gribble FM, Ashcroft FM. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel expressed in pancreatic b-cells, brain, heart abd skeletal muscle. FEBS Lett. 1995; 377:338-344.Clement IV JP, Kunjilwar K, Gonzalez G, et al. Association and stoichiometry of KATP channel subunits. Neuron. 1997; 18:827-838.Clement IV JP, Kunjilwar K, Gonzalez G, et al. Association and stoichiometry of KATP channel subunits. Neuron. 1997; 18:827-838.Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive К-channels in theabsence of the sulphonylurea receptor. Nature. 1997; 387:179-181.Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive К-channels in theabsence of the sulphonylurea receptor. Nature. 1997; 387:179-181.Gribble FM, Tucker SJ, Ashcroft FM. The interaction of nucleotides with the tolbutamide block of KATP currents: a reinterpretation. J Physiol. 1997; 504:35-45.Gribble FM, Tucker SJ, Ashcroft FM. The interaction of nucleotides with the tolbutamide block of KATP currents: a reinterpretation. J Physiol. 1997; 504:35-45.Gribble FM, Tucker SJ, Seino S, Ashcroft FM. Tissue specificity of sulfonylureas: studies on cloned cardiac and b-cell KATP channels. Diabetes. 1998; 47:1412-1418.Gribble FM, Tucker SJ, Seino S, Ashcroft FM. Tissue specificity of sulfonylureas: studies on cloned cardiac and b-cell KATP channels. Diabetes. 1998; 47:1412-1418.Gribble FM, Ashcroft FM. Differential sensitivity of b-cell and extrapancreatic KATP channels to gliclazide. Diabetologia. 1999;42:845-848. 'Gribble FM, Ashcroft FM. Differential sensitivity of b-cell and extrapancreatic KATP channels to gliclazide. Diabetologia. 1999;42:845-848. 'ZRnkier BJ, Lins S, Ohno-Shosaku T, Trube G, Panten U. Cytosolic ADP enhances the sensitivity of tolbutamide of ATP-dependent K+ channels from pancreatic b-cells. FEBS Lett. 1988; 239:241-244.ZRnkier BJ, Lins S, Ohno-Shosaku T, Trube G, Panten U. Cytosolic ADP enhances the sensitivity of tolbutamide of ATP-dependent K+ channels from pancreatic b-cells. FEBS Lett. 1988; 239:241-244.Sator G, Melander A, ScherstOn B, WMhein-Boll E. Influence of food and age on the single-dose kinetics and effects of tolbutamide and chlorpropamide. Eur J Clin Pharmacol. 1980; 17:285-293.Sator G, Melander A, ScherstOn B, WMhein-Boll E. Influence of food and age on the single-dose kinetics and effects of tolbutamide and chlorpropamide. Eur J Clin Pharmacol. 1980; 17:285-293.Sator G, Melander A, ScherstOn B, WMhein-Boll E. Serum glibenclamide in diabetic patients, and influence of food on the kinetics and effects of glibenclamide. Diabetologia. 1980; 18:17-22.Sator G, Melander A, ScherstOn B, WMhein-Boll E. Serum glibenclamide in diabetic patients, and influence of food on the kinetics and effects of glibenclamide. Diabetologia. 1980; 18:17-22.Nichols CG, Lederer WJ. Adenosine triphosphate-sensitive potassium channels in the cardio-vascular system. Am J Physiol. 1991; 261: H1675-H1686.Nichols CG, Lederer WJ. Adenosine triphosphate-sensitive potassium channels in the cardio-vascular system. Am J Physiol. 1991; 261: H1675-H1686.Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly-rectifying potassium channels in smooth muscle. Physiol Rev. 1997; 77:1165-1232.Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly-rectifying potassium channels in smooth muscle. Physiol Rev. 1997; 77:1165-1232.Davis NW, Standen NB, Stanfield PR. ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions. J Bioenerg Biomembr. 1991; 23:509-535.Davis NW, Standen NB, Stanfield PR. ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions. J Bioenerg Biomembr. 1991; 23:509-535.Schmid-Antomarchi H, Amoroso S, Fosset M, Lazdunski M. K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion. Proc Natl Acad Sci USA. 1990; 87:3489-3492.Schmid-Antomarchi H, Amoroso S, Fosset M, Lazdunski M. K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion. Proc Natl Acad Sci USA. 1990; 87:3489-3492.Heurteax C, Bertaina V, Widmann C, Lazdunski M. K+ channel openers prevent global ischemia-induced expression of c- fos, c-jun, heat shock protein and amyloid b-protein precursor genes and neuronal death in rat hippocampus. Proc Natl Acad Sci USA. 1993; 90:9431-9435.Heurteax C, Bertaina V, Widmann C, Lazdunski M. K+ channel openers prevent global ischemia-induced expression of c- fos, c-jun, heat shock protein and amyloid b-protein precursor genes and neuronal death in rat hippocampus. Proc Natl Acad Sci USA. 1993; 90:9431-9435.Venkatesh N, Lamp ST, Weiss JN. Sulfonylureas, ATP-sensitive K+ channels and cellular К ‘ loss during hypoxia, ischemia and metabolic inhibition in mammalian ventricle. Circ Res. 1991; 69:623-637.Venkatesh N, Lamp ST, Weiss JN. Sulfonylureas, ATP-sensitive K+ channels and cellular К ‘ loss during hypoxia, ischemia and metabolic inhibition in mammalian ventricle. Circ Res. 1991; 69:623-637.UKPDS: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type-2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.UKPDS: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type-2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.Leibowitz G, Cerasi E. Sulphonylurea treatment of NIDDM patients with cardiovascular disease: a mixed blessing? Diabetologia. 1996;39:503-514.Leibowitz G, Cerasi E. Sulphonylurea treatment of NIDDM patients with cardiovascular disease: a mixed blessing? Diabetologia. 1996;39:503-514.

The authors declare that there are no conflicts of interest present.