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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl11899</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11899</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Автоматизированный расчет параметра RD в эугликемическом инсулинемическом клэмпе</article-title><trans-title-group xml:lang="en"><trans-title>Automated calculation of the RD parameter in euglycemic insulinmic clamp</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Древаль</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dreval</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суздальницкий</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Suzdalnitsky</surname><given-names>R. S.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Древаль</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Dreval</surname><given-names>T. P.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Владимиров</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vladimirov</surname><given-names>P. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байрамкулов</surname><given-names>X. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bairamkulov</surname><given-names>Kh. D.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Titova</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гребенев</surname><given-names>Д. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Grebenev</surname><given-names>D. E.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анькина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Anykina</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;ЦНИИ спорта&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Central research Institute of sports&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>1993</year></pub-date><pub-date pub-type="epub"><day>15</day><month>02</month><year>1993</year></pub-date><volume>39</volume><issue>1</issue><issue-title>ТОМ 39, №1 (1993)</issue-title><fpage>15</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Древаль А.В., Суздальницкий Р.С., Древаль Т.П., Владимиров П.В., Байрамкулов X.Д., Титова Г.В., Гребенев Д.Е., Анькина Н.В., 1993</copyright-statement><copyright-year>1993</copyright-year><copyright-holder xml:lang="ru">Древаль А.В., Суздальницкий Р.С., Древаль Т.П., Владимиров П.В., Байрамкулов X.Д., Титова Г.В., Гребенев Д.Е., Анькина Н.В.</copyright-holder><copyright-holder xml:lang="en">Dreval A.V., Suzdalnitsky R.S., Dreval T.P., Vladimirov P.V., Bairamkulov K.D., Titova G.V., Grebenev D.E., Anykina N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11899">https://www.probl-endojournals.ru/jour/article/view/11899</self-uri><abstract><p>Авторы предложили новый аналитический подход к поиску параметра RD в эугликемическом инсулинемическом клэмпе, который отражает скорость инфузии глюкозы. Были обследованы два пациента с диабетом (параметр RD в первом случае определялся интуитивно, а во втором - на основе математических итерационных формул). Аналитический подход позволил сократить время исследования клэмпа в два раза, улучшив его качество.</p></abstract><trans-abstract xml:lang="en"><p>The authors proposed a new analytical approach to a search for the RD parameter in euglycemic insulinemic clamp which imparts a rate to glucose infusion. Two diabetic patients were investigated (RD parameter in the first case was determined by intuition, and in the second case — on the basis of mathematical iterative formulas). The analytical approach permitted a two-fold reduction of the time of clamp investigation improving its quality.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эугликемический инсулинемический клэмп</kwd><kwd>инсулинорезистентность</kwd><kwd>параметр RD</kwd></kwd-group><kwd-group xml:lang="en"><kwd>euglycemic insulinemic clamp</kwd><kwd>insulin resistance</kwd><kwd>RD parameter</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Древаль А. В. // Пробл. эндокринол.— 1992.— №6.— С. 35.</mixed-citation><mixed-citation xml:lang="en">Древаль А. В. // Пробл. эндокринол.— 1992.— №6.— С. 35.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Старостина Е. Г. Исследование чувствительности к инсулину и эффективности интенсифицированной инсулинотерапии у больных сахарным диабетом I типа: Дис. ... канд. мед. наук.— М., 1989.</mixed-citation><mixed-citation xml:lang="en">Старостина Е. Г. Исследование чувствительности к инсулину и эффективности интенсифицированной инсулинотерапии у больных сахарным диабетом I типа: Дис. ... канд. мед. наук.— М., 1989.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Christin L., Nacht С.-А., Vernet О. et al. // J. clin. Invest.— 1986,—Vol. 77,—P. 1747—1755.</mixed-citation><mixed-citation xml:lang="en">Christin L., Nacht С.-А., Vernet О. et al. // J. clin. Invest.— 1986,—Vol. 77,—P. 1747—1755.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">De Fronzo R. A., Tobin J. D., Andres R. // Amer. J. Physiol.— 1979,—Vol. 273, N 3,—P. E214—E223.</mixed-citation><mixed-citation xml:lang="en">De Fronzo R. A., Tobin J. D., Andres R. // Amer. J. Physiol.— 1979,—Vol. 273, N 3,—P. E214—E223.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Verdonk C. A., Rizza R. A., Westland R. E. et al. // Horm. Metab. Res.—1980,—Vol. 12,—P. 133—135.</mixed-citation><mixed-citation xml:lang="en">Verdonk C. A., Rizza R. A., Westland R. E. et al. // Horm. Metab. Res.—1980,—Vol. 12,—P. 133—135.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
