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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl11917</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-11917</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Клинико-цитогенетическое обследование больных транссексуализмом</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and cytogenetic examinations of patients with transsexualism</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>G. I.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинченко</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinchenko</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слонимский</surname><given-names>Б. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Slonimsky</surname><given-names>B. Yu.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курило</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurilo</surname><given-names>L. F.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абакумова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Abakumova</surname><given-names>N. S.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мхитарова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mkhitarova</surname><given-names>Ye. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шилейко</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shileiko</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">probl@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;ГУ Эндокринологический научный центр РАМН; Медико-генетический научный центр РАМН&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinology Research Centre; Medical Genetic Research Center&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>1996</year></pub-date><pub-date pub-type="epub"><day>15</day><month>02</month><year>1996</year></pub-date><volume>42</volume><issue>1</issue><issue-title>ТОМ 42, №1 (1996)</issue-title><fpage>25</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козлов Г.И., Калинченко С.Ю., Слонимский Б.Ю., Курило Л.Ф., Абакумова Н.С., Мхитарова Е.В., Шилейко Л.В., 1996</copyright-statement><copyright-year>1996</copyright-year><copyright-holder xml:lang="ru">Козлов Г.И., Калинченко С.Ю., Слонимский Б.Ю., Курило Л.Ф., Абакумова Н.С., Мхитарова Е.В., Шилейко Л.В.</copyright-holder><copyright-holder xml:lang="en">Kozlov G.I., Kalinchenko S.Y., Slonimsky B.Y., Kurilo L.F., Abakumova N.S., Mkhitarova Y.V., Shileiko L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/11917">https://www.probl-endojournals.ru/jour/article/view/11917</self-uri><abstract><p>Пациенты с транссексуализмом мужского и женского пола были обследованы с использованием клинических, цитогенетических, гаметологических и морфологических методов. Было показано, что все пациенты обладают нормальным кариотипом без нарушений числа или структуры хромосом. Признаки склерокистозных яичников были выявлены у 25% пациентов с транссексуализмом у женщин до лечения; после андрогенной терапии от 1 до 3 лет в 100% случаев наблюдались признаки склерокистозных яичников и подавление фолликулогенеза. Все пациенты с транссексуализмом мужского пола имели олигоастенотератозооспермию и дегенерацию незрелых половых клеток перед началом терапии.</p></abstract><trans-abstract xml:lang="en"><p>Patients with male and female transsexualism were examined using clinical, cytogenetic, gametological and morphological methods. All patients were shown to possess normal karyotype without disorders in chromosome number or structure. Signs of sclerocystic ovaries were detected in 25% of patients with female transsexualism before treatment; after androgen therapy of 1 to 3 years signs of sclerocystic ovaries and folliculogenesis suppression were observed in 100% cases. All the patients with male transsexualism presented with spermatogenesis in the form of oligoasthenoteratozoospermia and degeneration of immature sex cells before therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>транссексуализм</kwd><kwd>цитогенетика</kwd><kwd>андрогены</kwd></kwd-group><kwd-group xml:lang="en"><kwd>transsexualism</kwd><kwd>cytogenetic</kwd><kwd>androgens</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васильченко Г.С. Сексопатология: Справочник. — М.,1990 - С.229-233.</mixed-citation><mixed-citation xml:lang="en">Васильченко Г.С. 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