problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl12375problendo-12375Research ArticleКлиническая эндокринологияClinical endocrinologyБолезнь Грейвса у пациентки с ВИЧ-инфекцией, получающей антиретровирусную терапиюGraves’ disease in HIV patient receiving antiretroviral therapyhttps://orcid.org/0000-0003-1500-1586МоргуноваТатьяна БорисовнаMorgunovaTatyana B.

к.м.н.

MD, PhD

tanmorgun@mail.ruhttps://orcid.org/0000-0002-2234-5283ЗоринаАнастасия АлександровнаZorinaAnastasia A.

студентка, 5 курс, лечебный факультет

zorinavgustina@ya.ruhttps://orcid.org/0000-0001-9881-5459МалолеткинаЕкатерина СтаниславовнаMaloletkinaEkaterina S.

врач-эндокринолог эндокринологического терапевтического отделения №2, Университетская клиническая больница №2

MD

EkaterinaMaloletkinae@gmail.comhttps://orcid.org/0000-0002-7000-0095СычЮлия ПетровнаSytchYulia P.

к.м.н.

MD, PhD

juliasytch@mail.ruhttps://orcid.org/0000-0001-7044-3921ВасильеваАриадна ВасильевнаVasilevaAriadna V.

ассистент кафедры эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

MD

ariadnic5@yandex.ruhttps://orcid.org/0000-0002-2504-7468ФадеевВалентин ВикторовичFadeyevValentin V.

д.м.н., профессор, член-корр. РАН

MD, PhD, Professor

walfad@mail.ruФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation2020160920206632226Copyright © Моргунова Т.Б., Зорина А.А., Малолеткина Е.С., Сыч Ю.П., Васильева А.В., Фадеев В.В., 20202020Моргунова Т.Б., Зорина А.А., Малолеткина Е.С., Сыч Ю.П., Васильева А.В., Фадеев В.В.Morgunova T.B., Zorina A.A., Maloletkina E.S., Sytch Y.P., Vasileva A.V., Fadeyev V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/12375

Статья посвящена клиническому случаю развития болезни Грейвса у пациентки с ВИЧ-инфекцией, получающей антиретровирусную терапию. За последние десятилетия число ВИЧ-инфицированных пациентов во всем мире существенно возросло. Применяемая на сегодняшний день высокоактивная антиретровирусная терапия позволяет существенно улучшить прогноз для этих пациентов. Однако ее применение сопряжено с рядом осложнений, в частности, развитием синдрома восстановления иммунитета, на фоне чего возможно развитие таких аутоиммунных заболеваний, как болезнь Грейвса, полимиозит и синдром Гийена–Барре. Поэтому хотелось бы обратить внимание врачей на возможность развития такого осложнения у больных, получающих антиретровирусную терапию. Своевременная диагностика и лечение нарушений функции щитовидной железы позволят избежать осложнений, сопряженных с избытком или дефицитом тиреоидных гормонов.

The article focuses on the clinical case of Graves’ disease in a patient with HIV infection who is receiving antiretroviral therapy. The number of HIV-infected patients has increased significantly in recent decades all over the world. The currently used highly active antiretroviral therapy can significantly improve the prognosis for these patients. However, its use is associated with a number of complications, in particular the development of immune reconstitution syndrome, under which the development of such autoimmune diseases as Graves’ disease, polymyositis and Guillain-Barre syndrome may occur. Therefore, we would like to draw the attention of doctors to the possibility of such a complication in patients receiving antiretroviral therapy. Timely diagnosis and treatment of thyroid disorders will help to avoid the complications associated with an excess or deficit of thyroid hormones.

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The authors declare that there are no conflicts of interest present.