problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl12741problendo-12741Research ArticleНарушения углеводного обменаCarbohidrates metabolism disturbanciesСахарный диабет и онкопатология: система инсулиноподобных факторов ростаDiabetes mellitus and cancer: a system of insulin-like growth factorshttps://orcid.org/0000-0003-3618-6890ФранциянцЕ. М.FrantsiyantsE. M.

Франциянц Елена Михайловна – доктор биологических наук, профессор, заместитель директора по науке.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 9427-9928

Elena M. Frantsiyants - PhD, Professor.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 9427-9928

super.gormon@ya.ruhttps://orcid.org/0000-0002-4318-7587СуриковаЕ. И.SurikovaE. I.

Сурикова Екатерина Игоревна - кандидат биологических наук.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 2401-4115

Ekaterina I. Surikova – PhD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 2401-4115

sunsur2000@mail.ruhttps://orcid.org/0000-0002-3972-2452КаплиеваИ. В.KaplievaI. V.

Каплиева Ирина Викторовна – доктор медицинских наук. Заведующая лабораторией ЛИПЗО.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 5047-1541

Irina V. Kaplieva – PhD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 5047-1541

kaplirina@yandex.ruhttps://orcid.org/0000-0002-2302-8271БандовкинаВ. A.BandovkinaV. A.

Бандовкина Валерия Ахтямовна - доктор биологических наук.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 8806-2641

Valeriya A. Bandovkina – PhD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 8806-2641

valerryana@yandex.ruhttps://orcid.org/0000-0002-7395-3086НескубинаИ. В.NeskubinaI. V.

Нескубина Ирина Валерьевна - кандидат биологических наук.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 3581-8531

Irina V. Neskubina – PhD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 3581-8531

neskubina.irina@mail.ruhttps://orcid.org/0000-0002-9616-8996ШейкоЕ. А.SheikoE. A.

Шейко Елена Александровна – кандидат биологических наук.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 7293-3480

Elena A. Sheiko – PhD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 7293-3480

esheiko@inbox.ruhttps://orcid.org/0000-0001-7640-6021МорозоваМ. И.MorozovaM. I.

Морозова Мария Игоревна - клинический ординатор.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

Mariya I. Morozova – MD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

maria-morozova94@yandex.ruhttps://orcid.org/0000-0003-0252-4708КотиеваИ. М.KotievaI. M.

Котиева Инга Мовлиевна – доктор медицинских наук.

344038, Ростов-на-Дону, ул. Погодина, д. 6 Б, кв. 38.

eLibrary SPIN: 3478-5811

Inga M. Kotieva - MD, PhD.

Pogodina st. 6 b ap. 38, 344038 Rostov on Don.

eLibrary SPIN: 3478-5811

kukulik70@mail.ruНациональный медицинский исследовательский центр онкологииРоссияNational Medical Research Centre for OncologyRussian Federation2021100920216753442Copyright © Франциянц Е.М., Сурикова Е.И., Каплиева И.В., Бандовкина В.A., Нескубина И.В., Шейко Е.А., Морозова М.И., Котиева И.М., 20212021Франциянц Е.М., Сурикова Е.И., Каплиева И.В., Бандовкина В.A., Нескубина И.В., Шейко Е.А., Морозова М.И., Котиева И.М.Frantsiyants E.M., Surikova E.I., Kaplieva I.V., Bandovkina V.A., Neskubina I.V., Sheiko E.A., Morozova M.I., Kotieva I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/12741

Сахарный диабет и злокачественные опухоли — одни из самых частых и сложных заболеваний. Эпидемиологические исследования показали наличие сильной взаимосвязи между этими патологиями. Причинность этой связи до сих пор однозначно не установлена, но предложен ряд вероятных биологических механизмов, объясняющих ее через эффекты гипергликемии, гиперинсулинемии на процесс онкогенеза. Важную роль при этом играет ось инсулиноподобных факторов роста, их рецепторов и связывающих белков (IGF/IGFR/IGFBP). В обзоре приведены данные о структурных элементах сигнальной оси инсулин/IGF/IGFR/IGFBP и их внутренних взаимосвязях при сахарном диабете и при развитии злокачественных опухолей. Значительные изменения в оси, происходящие при формировании диабетической среды, подготавливают фон, который при определенных условиях может обусловить стимуляцию или ингибирование развития опухоли. Рассмотренная сигнальная система, играя значительную роль в физиологии нормальных клеток, зачастую функционирует как решающий фактор выживания опухолевых клеток, обеспечивая тонкую контекстно-зависимую регуляцию многих клеточных процессов, связанных с онкогенезом. Однако, несмотря на многолетние глубокие исследования патогенеза сахарного диабета и злокачественных опухолей, молекулярные механизмы взаимосвязи этих патологий еще в значительной степени неясны, а внутренняя неоднородность патологий усложняет проведение исследований и интерпретацию результатов, оставляя множество вопросов.

Diabetes mellitus and malignant tumors are among the most common and complex diseases. Epidemiological studies have shown a strong relationship between these pathologies. The causality of this relationship has not yet been unambiguously established, but a number of probable biological mechanisms have been proposed to explain it through the effects of hyperglycemia, hyperinsulinemia on the process of oncogenesis. An important role in this is played by the axis of insulin-like growth factors, their receptors and binding proteins (IGF / IGFR / IGFBP). The review provides data on the structural elements of the insulin / IGF / IGFR / IGFBP signaling axis and their internal relationships in diabetes mellitus and in the development of malignant tumors. Significant changes in the axis that occur during the formation of the diabetic environment prepare the background, which, under certain conditions, can lead to the stimulation or inhibition of tumor development. The considered signaling system, playing a significant role in the physiology of normal cells, often functions as a decisive factor in the survival of tumor cells, providing fine context-dependent regulation of many cellular processes associated with oncogenesis. However, despite many years of in-depth studies of the pathogenesis of diabetes mellitus and malignant tumors, the molecular mechanisms of the relationship between these pathologies are still largely unclear, and the internal heterogeneity of pathologies complicates research and interpretation of the results, leaving many questions.

сахарный диабетонкопатологиязлокачественные опухолисистема инсулиноподобных факторов ростаdiabetes mellitusoncopathologymalignant tumorsinsulin-like growth factors systemПоисково-аналитическая работа проведена в рамках государственного задания: «Коморбидные заболевания как модификаторы течения злокачественного процесса».International Diabetes Federation. IDF Diabetes Atlas. 9th ed. Brussels: IDF; 2019.Dedov Ivan I. Shestakova Marina V. Vikulova Olga K. Zheleznyakova Anna V. Isakov Michail А. Diabetes mellitus in Russian Federation: prevalence, morbidity, mortality, parameters of glycaemic control and structure of glucose lowering therapy according to the Federal Diabetes Register, status 2017 Diabetes mellitus 2018 08 144 159 21 3 10.14341/dm9686Cancer tomorrow. Available from: https://gco.iarc.fr/tomorrow/homeMalignant neoplasms in Russia in 2019 (morbidity and mortality). Ed. by Kaprin AD, Starinsky VV, Shahzadova AO. Moscow; 2020. 252 p. (In Russ.).Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today. Lyon: International Agency for Research on Cancer; 2020. Available from: https://gco.iarc.fr/today [cited 2021 Feb.]Barnett Karen Mercer Stewart W Norbury Michael Watt Graham Wyke Sally Guthrie Bruce Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study The Lancet 2012 05 37 43 380 9836 10.1016/s0140-6736(12)60240-2Arreskov Anne Beiter Olsen Maria Å. Pouplier Sandra Sinius Siersma Volkert Andersen Christen L. Friis Søren de Fine Olivarius Niels The impact of cancer on diabetes outcomes BMC Endocrine Disorders 2019 06 19 1 10.1186/s12902-019-0377-0Cignarelli Angelo Genchi Valentina Annamaria Caruso Irene Natalicchio Annalisa Perrini Sebastio Laviola Luigi Giorgino Francesco Diabetes and cancer: Pathophysiological fundamentals of a ‘dangerous affair’ Diabetes Research and Clinical Practice 2018 04 378 388 143 10.1016/j.diabres.2018.04.002Ballotari Paola Vicentini Massimo Manicardi Valeria Gallo Marco Chiatamone Ranieri Sofia Greci Marina Giorgi Rossi Paolo Diabetes and risk of cancer incidence: results from a population-based cohort study in northern Italy BMC Cancer 2017 10 17 1 10.1186/s12885-017-3696-4Scappaticcio Lorenzo Maiorino Maria Ida Bellastella Giuseppe Giugliano Dario Esposito Katherine Insights into the relationships between diabetes, prediabetes, and cancer Endocrine 2016 12 231 239 56 2 10.1007/s12020-016-1216-yGiri B., Dey S., Das T., et al. Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity. Biomed. Pharmacother. 2018;107:306-328. doi: https://doi.org/10.1016/j.biopha.2018.07.157Wojciechowska J. Krajewski W. Bolanowski M. Kręcicki T. Zatoński T. Diabetes and Cancer: a Review of Current Knowledge Experimental and Clinical Endocrinology & Diabetes 2016 05 263 275 124 05 10.1055/s-0042-100910Suh Sunghwan Kim Kwang-Won Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment Diabetes & Metabolism Journal 2019 12 733 43 6 10.4093/dmj.2019.0177Elena Joanne W. Steplowski Emily Yu Kai Hartge Patricia Tobias Geoffrey S. Brotzman Michelle J. Chanock Stephen J. Stolzenberg-Solomon Rachael Z. Arslan Alan A. Bueno-de-Mesquita H. Bas Helzlsouer Kathy Jacobs Eric J. LaCroix Andrea Petersen Gloria Zheng Wei Albanes Demetrius Allen Naomi E. Amundadottir Laufey Bao Ying Boeing Heiner Boutron-Ruault Marie-Christine Buring Julie E. Gaziano J. Michael Giovannucci Edward L. Duell Eric J. Hallmans Göran Howard Barbara V. Hunter David J. Hutchinson Amy Jacobs Kevin B. Kooperberg Charles Kraft Peter Mendelsohn Julie B. Michaud Dominique S. Palli Domenico Phillips Lawrence S. Overvad Kim Patel Alpa V. Sansbury Leah Shu Xiao-Ou Simon Michael S. Slimani Nadia Trichopoulos Dimitrios Visvanathan Kala Virtamo Jarmo Wolpin Brian M. Zeleniuch-Jacquotte Anne Fuchs Charles S. Hoover Robert N. Gross Myron Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium Cancer Causes & Control 2012 10 13 25 24 1 10.1007/s10552-012-0078-8Li Yan Bian Xiaohui Wei Shuyi He Meizhi Yang Yuelian <p>The relationship between pancreatic cancer and type 2 diabetes: cause and consequence</p> Cancer Management and Research 2019 09 8257 8268 Volume 11 10.2147/cmar.s211972Klein Alison P. Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors Nature Reviews Gastroenterology & Hepatology 2021 05 493 502 18 7 10.1038/s41575-021-00457-xHardefeldt Prue J Edirimanne Senarath Eslick Guy D Diabetes increases the risk of breast cancer: a meta-analysis Endocrine-Related Cancer 2012 10 793 803 19 6 10.1530/erc-12-0242Zhang Dongyu Li Nan Xi Yuzhi Zhao Yuan Wang Tengteng Diabetes mellitus and risk of ovarian cancer. A systematic review and meta-analysis of 15 cohort studies Diabetes Research and Clinical Practice 2017 04 43 52 130 10.1016/j.diabres.2017.04.005Wang Lihai Zhong Lei Xu Bin Chen Min Huang Hongxiao Diabetes mellitus and the risk of ovarian cancer: a systematic review and meta-analysis of cohort and case–control studies BMJ Open 2020 12 e040137 10 12 10.1136/bmjopen-2020-040137Overbeek Jetty A. Kuiper Josephina G. van der Heijden Amber A. W. A. Labots Mariette Haug Ulrike Herings Ron M. C. Nijpels Giel Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes International Journal of Colorectal Disease 2018 11 269 276 34 2 10.1007/s00384-018-3191-7Cheng Hsiu-Chung Chang Tsung-Kun Su Wei-Chih Tsai Hsiang-Lin Wang Jaw-Yuan Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes Translational Oncology 2021 04 101089 14 7 10.1016/j.tranon.2021.101089Wang Xiaofeng Wang Huiyu Zhang Tianfu Cai Lu Dai Enyong He Jinting Diabetes and its Potential Impact on Head and Neck Oncogenesis Journal of Cancer 2019 12 583 591 11 3 10.7150/jca.35607Chodick Gabriel Heymann Anthony D. Rosenmann Lena Green Manfred S. Flash Shira Porath Avi Kokia Ehud Shalev Varda Diabetes and risk of incident cancer: a large population-based cohort study in Israel Cancer Causes & Control 2010 02 879 887 21 6 10.1007/s10552-010-9515-8Zhou X. H. Qiao Q. Zethelius B. Pyörälä K. Söderberg S. Pajak A. Stehouwer C. D. A. Heine R. J. Jousilahti P. Ruotolo G. Nilsson P. M. Calori G. Tuomilehto J. Diabetes, prediabetes and cancer mortality Diabetologia 2010 05 1867 1876 53 9 10.1007/s00125-010-1796-7Kira Sakurako Ito Chikako Fujikawa Rumi Misumi Munechika Increased cancer mortality among Japanese individuals with hyperinsulinemia Metabolism Open 2020 07 100048 7 10.1016/j.metop.2020.100048Islam Zobida Akter Shamima Inoue Yosuke Hu Huan Kuwahara Keisuke Nakagawa Tohru Honda Toru Yamamoto Shuichiro Okazaki Hiroko Miyamoto Toshiaki Ogasawara Takayuki Sasaki Naoko Uehara Akihiko Yamamoto Makoto Kochi Takeshi Eguchi Masafumi Shirasaka Taiki Shimizu Makiko Nagahama Satsue Hori Ai Imai Teppei Nishihara Akiko Tomita Kentaro Sone Tomofumi Konishi Maki Kabe Isamu Mizoue Tetsuya Dohi Seitaro Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study Diabetes Care 2021 01 757 764 44 3 10.2337/dc20-1213Klil-Drori AJ, Azoulay L, Pollak MN. Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing? Nat Rev Clin Oncol. 2017;14(2):85-99. doi: https://doi.org/10.1038/nrclinonc.2016.120Miao Zhi-Feng Xu Hao Xu Ying-Ying Wang Zhen-Ning Zhao Ting-Ting Song Yong-Xi Xu Hui-Mian Diabetes mellitus and the risk of gastric cancer: a meta-analysis of cohort studies Oncotarget 2017 03 44881 44892 8 27 10.18632/oncotarget.16487Zheng Jiaojiao Rutegård Martin Santoni Giola Wallner Bengt Johansson Ingegerd Sund Malin Xie Shao-Hua Lagergren Jesper Prediabetes and diabetes in relation to risk of gastric adenocarcinoma British Journal of Cancer 2019 05 1147 1152 120 12 10.1038/s41416-019-0470-1Rentsch Christopher T Farmer Ruth E Eastwood Sophie V Mathur Rohini Garfield Victoria Farmaki Aliki-Eleni Bhaskaran Krishnan Chaturvedi Nish Smeeth Liam Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank BMJ Open Diabetes Research & Care 2020 08 e001600 8 1 10.1136/bmjdrc-2020-001600Zhang Anni M.Y. Wellberg Elizabeth A. Kopp Janel L. Johnson James D. Hyperinsulinemia in Obesity, Inflammation, and Cancer Diabetes & Metabolism Journal 2021 03 285 311 45 3 10.4093/dmj.2020.0250Wang Mina Yang Yingying Liao Zehuan Diabetes and cancer: Epidemiological and biological links World Journal of Diabetes 2020 06 227 238 11 6 10.4239/wjd.v11.i6.227Supabphol Suangson Seubwai Wunchana Wongkham Sopit Saengboonmee Charupong High glucose: an emerging association between diabetes mellitus and cancer progression Journal of Molecular Medicine 2021 05 1175 1193 99 9 10.1007/s00109-021-02096-wBrouwer-Visser Jurriaan Huang Gloria S. IGF2 signaling and regulation in cancer Cytokine & Growth Factor Reviews 2015 02 371 377 26 3 10.1016/j.cytogfr.2015.01.002Livingstone C. IGF2 and cancer. Endocr Relat Cancer. 2013;20(6):R321-339. doi: https://doi.org/10.1530/ERC-13-0231Begemann Matthias Zirn Birgit Santen Gijs Wirthgen Elisa Soellner Lukas Büttel Hans-Martin Schweizer Roland van Workum Wilbert Binder Gerhard Eggermann Thomas Paternally Inherited IGF2 Mutation and Growth Restriction New England Journal of Medicine 2015 07 349 356 373 4 10.1056/nejmoa1415227Poloz Y, Stambolic V. Obesity and cancer, a case for insulin signaling. Cell Death Dis. 2015;6(12):e2037. doi: https://doi.org/10.1038/cddis.2015.381Allard John B. Duan Cunming IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? Frontiers in Endocrinology 2018 04 9 10.3389/fendo.2018.00117Belfiore A, Malaguarnera R, Vella V, et al. Insulin Receptor Isoforms in Physiology and Disease: An Updated View. Endocr Rev. 2017;38(5):379-431. doi: https://doi.org/10.1210/er.2017-00073Savkur Rajesh S. Philips Anne V. Cooper Thomas A. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy Nature Genetics 2002 07 40 47 29 1 10.1038/ng704Lero Michael W. Shaw Leslie M. Diversity of insulin and IGF signaling in breast cancer: Implications for therapy Molecular and Cellular Endocrinology 2021 02 111213 527 10.1016/j.mce.2021.111213Kim Min Sun Lee Dae-Yeol Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus Annals of Pediatric Endocrinology & Metabolism 2015 07 69 20 2 10.6065/apem.2015.20.2.69Hakuno F, Takahashi SI. IGF1 receptor signaling pathways. J Mol Endocrinol. 2018;61(1):T69-T86. doi: https://doi.org/10.1530/JME-17-0311Liefers-Visser J.A.L. Meijering R.A.M. Reyners A.K.L. van der Zee A.G.J. de Jong S. IGF system targeted therapy: Therapeutic opportunities for ovarian cancer Cancer Treatment Reviews 2017 09 90 99 60 10.1016/j.ctrv.2017.08.012Baxter RC. IGF binding proteins in cancer: mechanistic and clinical insights. Nat Rev Cancer. 2014;14(5):329-341. doi: 1 https://doi.org/10.1038/nrc3720Haywood Natalie J. Slater Thomas A. Matthews Connor J. Wheatcroft Stephen B. The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes Molecular Metabolism 2018 10 86 96 19 10.1016/j.molmet.2018.10.008Clemmons David R. Role of IGF Binding Proteins in Regulating Metabolism Trends in Endocrinology & Metabolism 2016 04 375 391 27 6 10.1016/j.tem.2016.03.019Rajpathak Swapnil N. Gunter Marc J. Wylie-Rosett Judith Ho Gloria Y. F. Kaplan Robert C. Muzumdar Radhika Rohan Thomas E. Strickler Howard D. The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes Diabetes/Metabolism Research and Reviews 2009 01 3 12 25 1 10.1002/dmrr.919Cohen Dara Hope LeRoith Derek Obesity, type 2 diabetes, and cancer: the insulin and IGF connection Endocrine-Related Cancer 2012 05 F27 F45 19 5 10.1530/erc-11-0374Talib Wamidh H. Mahmod Asma Ismail Abuarab Sara Feras. Hasen Eliza Munaim Amer A. Haif Shatha Khaled Ayyash Amani Marwan Khater Samar AL-Yasari Intisar Hadi Kury Lina T. Al Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products Molecules 2021 04 2179 26 8 10.3390/molecules26082179Rajpathak Swapnil N. He Meian Sun Qi Kaplan Robert C. Muzumdar Radhika Rohan Thomas E. Gunter Marc J. Pollak Michael Kim Mimi Pessin Jeffrey E. Beasley Jeannette Wylie-Rosett Judith Hu Frank B. Strickler Howard D. Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women Diabetes 2012 05 2248 2254 61 9 10.2337/db11-1488Öberg Daniel Salemyr Jenny Örtqvist Eva Juul Anders Bang Peter A longitudinal study of serum insulin-like growth factor-I levels over 6 years in a large cohort of children and adolescents with type 1 diabetes mellitus: A marker reflecting diabetic retinopathy Pediatric Diabetes 2018 04 972 978 19 5 10.1111/pedi.12681Chisalita Simona I. Ludvigsson J. Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes Journal of Diabetes Research 2018 03 1 6 2018 10.1155/2018/8623560Shapiro Melanie R. Wasserfall Clive H. McGrail Sean M. Posgai Amanda L. Bacher Rhonda Muir Andrew Haller Michael J. Schatz Desmond A. Wesley Johnna D. von Herrath Matthias Hagopian William A. Speake Cate Atkinson Mark A. Brusko Todd M. Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis Diabetes 2019 12 413 423 69 3 10.2337/db19-0942Hedman Christina A. Frystyk Jan Lindström Torbjörn Chen Jian-Wen Flyvbjerg Allan Ørskov Hans Arnqvist Hans J Residual β-Cell Function More than Glycemic Control Determines Abnormalities of the Insulin-Like Growth Factor System in Type 1 Diabetes The Journal of Clinical Endocrinology & Metabolism 2004 12 6305 6309 89 12 10.1210/jc.2004-0572Gutefeldt Kerstin Hedman Christina A. Thyberg Ingrid S.M. Bachrach-Lindström Margareta Spångeus Anna Arnqvist Hans J. Dysregulated growth hormone-insulin-like growth factor-1 axis in adult type 1 diabetes with long duration Clinical Endocrinology 2018 07 424 430 89 4 10.1111/cen.13810Sharma Ashok Purohit Sharad Sharma Shruti Bai Shan Zhi Wenbo Ponny Sithara Raju Hopkins Diane Steed Leigh Bode Bruce Anderson Stephen W. She Jin-Xiong IGF-Binding Proteins in Type-1 Diabetes Are More Severely Altered in the Presence of Complications Frontiers in Endocrinology 2016 01 7 10.3389/fendo.2016.00002Raisingani Manish Preneet Brar Kohn Brenda Yakar Shoshana Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis Growth Hormone & IGF Research 2017 04 13 21 34 10.1016/j.ghir.2017.04.003Kasprzak A, Kwasniewski W, Adamek A, Gozdzicka-Jozefiak A. Insulin-like growth factor (IGF) axis in cancerogenesis. Mutat Res Rev Mutat Res. 2017;772:78-104. doi: https://doi.org/10.1016/j.mrrev.2016.08.007Venkatachalam Senthiladipan Mettler Esther Fottner Christian Miederer Matthias Kaina Bernd Weber Matthias M. The impact of the IGF-1 system of cancer cells on radiation response – An in vitro study Clinical and Translational Radiation Oncology 2017 10 1 8 7 10.1016/j.ctro.2017.09.006Osher Eliot Macaulay Valentine M. Therapeutic Targeting of the IGF Axis Cells 2019 08 895 8 8 10.3390/cells8080895Renehan Andrew G Zwahlen Marcel Minder Christoph O'Dwyer Sarah T Shalet Stephen M Egger Matthias Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis The Lancet 2004 04 1346 1353 363 9418 10.1016/s0140-6736(04)16044-3Dal Jakob Leisner Michelle Z Hermansen Kasper Farkas Dóra Körmendiné Bengtsen Mads Kistorp Caroline Nielsen Eigil H Andersen Marianne Feldt-Rasmussen Ulla Dekkers Olaf M Sørensen Henrik Toft Jørgensen Jens Otto Lunde Cancer Incidence in Patients With Acromegaly: A Cohort Study and Meta-Analysis of the Literature The Journal of Clinical Endocrinology & Metabolism 2018 03 2182 2188 103 6 10.1210/jc.2017-02457Ruchala Marek Wolinski Kosma Health-Related Complications of Acromegaly—Risk of Malignant Neoplasms Frontiers in Endocrinology 2019 04 10 10.3389/fendo.2019.00268Werner Haim Lapkina-Gendler Lena Achlaug Laris Nagaraj Karthik Somri Lina Yaron-Saminsky Danielle Pasmanik-Chor Metsada Sarfstein Rive Laron Zvi Yakar Shoshana Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways Cells 2019 06 596 8 6 10.3390/cells8060596Werner Haim Sarfstein Rive Nagaraj Karthik Laron Zvi Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation Cells 2020 11 2446 9 11 10.3390/cells9112446Sarfstein Rive Werner Haim Tumor suppressor p53 regulates insulin receptor ( INSR ) gene expression via direct binding to the INSR promoter Oncotarget 2020 06 2424 2437 11 25 10.18632/oncotarget.27645Mancarella Caterina Morrione Andrea Scotlandi Katia Novel Regulators of the IGF System in Cancer Biomolecules 2021 02 273 11 2 10.3390/biom11020273Fernandez Cornelius J George Annu Susan Subrahmanyan Nikhila A Pappachan Joseph M Epidemiological link between obesity, type 2 diabetes mellitus and cancer World Journal of Methodology 2021 05 23 45 11 3 10.5662/wjm.v11.i3.23Ji-Yan Liu Xin Chen Jing Ding Jie Tang Wu-Xia Luo Meng Qiu The expression difference of insulin-like growth factor 1 receptor in breast cancers with or without diabetes Journal of Cancer Research and Therapeutics 2016 02 295 11 2 10.4103/0973-1482.138195Ding Jing Tang Jie Chen Xin Men Hai-Tao Luo Wu-Xia Du Yang Ge Jun Li Cong Chen Ye Cheng Ke Qiu Meng Liu Ji-Yan Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus Asian Pacific Journal of Cancer Prevention 2014 03 5675 5680 14 10 10.7314/apjcp.2013.14.10.5675Srivastava Swayam Prakash Goodwin Julie E. Cancer Biology and Prevention in Diabetes Cells 2020 06 1380 9 6 10.3390/cells9061380Belfiore A, Frasca F, Pandini G, et al. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev. 2009;30(6):586-623. doi: https://doi.org/10.1210/er.2008-0047Rahman Ishrat Athar Md Tanwir Islam Mozaffarul Type 2 Diabetes, Obesity, and Cancer Share Some Common and Critical Pathways Frontiers in Oncology 2021 01 10 10.3389/fonc.2020.600824Sarfstein Rive Pasmanik-Chor Metsada Yeheskel Adva Edry Liat Shomron Noam Warman Naama Wertheimer Efrat Maor Sharon Shochat Lea Werner Haim Insulin-like Growth Factor-I Receptor (IGF-IR) Translocates to Nucleus and Autoregulates IGF-IR Gene Expression in Breast Cancer Cells Journal of Biological Chemistry 2011 12 2766 2776 287 4 10.1074/jbc.m111.281782Bach LA. IGF-binding proteins. J Mol Endocrinol. 2018;61(1):T11-T28. doi: https://doi.org/10.1530/JME-17-0254Lin YW, Weng XF, Huang BL, et al. IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications. Am J Transl Res. 2021;13(3):813-832.

The authors declare that there are no conflicts of interest present.