problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl12777problendo-12777Research ArticleКлиническая эндокринологияClinical endocrinologyКлинико-рентгенологическая диагностика гипофизита: обзор литературы и собственные наблюденияClinical and radiological diagnosis of hypophysitis: a review of literature and own datahttps://orcid.org/0000-0002-2791-3278ВоронцовА. В.VorontsovA. V.

Воронцов Александр Валерьевич, доктор медицинских наук, профессор

117036, Москва, ул. Дм. Ульянова, д. 11

eLibrary SPIN: 2502-4463

Aleksandr V. Vorontsov, MD, PhD, Professo

117036, Москва, ул. Дм. Ульянова, д. 11

mr2005i@mail.ruhttps://orcid.org/0000-0002-2812-7017БабаеваД. М.BabaevaD. M.

Бабаева Диана Мажлумовна, врач-рентгенолог  

Москва

eLibrary SPIN: 6431-9855; 

Diana M. Babaeva, MD

Москва

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dianababaeva1@yandex.ruhttps://orcid.org/0000-0002-7775-7568ВладимироваВ. П.VladimirovaV. P.

Владимирова Виктория Павловна, кандидат медицинских науr, ведущий научный сотрудник, врач-рентгенолог  

Москва

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Victoria P. Vladimirova, MD, PhD

Москва

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vpv970@gmail.comhttps://orcid.org/0000-0003-1413-1549ДубовицкаяТ. А.DubovitskayaT. A.

Дубовицкая Татьяна Алексеевна, кандидат медицинских наук, врач-эндокринолог 

Москва

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Tatiana A. Dubovitskaya, MD, PhD

Москва

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grebennikova@hotmail.comhttps://orcid.org/0000-0001-8148-8180ГавриловаА. О.GavrilovaA. O.

Гаврилова Алина Олеговна, аспирант

Москва

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Alina O. Gavrilova, PhD student

Москва

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a.o.gavrilova@list.ruhttps://orcid.org/0000-0002-6674-6441БелаяЖ. Е.BelayaZh. E.

Белая Жанна Евгеньевна, доктор медицинских наук, заведующая отделением нейроэндокринологии и остеопатий

Москва

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Zhanna E. Belaya, MD, PhD

Москва

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jannabelaya@gmail.comhttps://orcid.org/0000-0002-9717-9742МокрышеваН. Г.MokryshevаN. G.

Мокрышева Наталья Георгиевна, доктор медицинских наук, профессор, член-корреспондент РАН

Москва

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Natalia G. Mokrysheva, MD, PhD, Professor

Москва

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nm70@mail.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2022300420226821633Copyright © Воронцов А.В., Бабаева Д.М., Владимирова В.П., Дубовицкая Т.А., Гаврилова А.О., Белая Ж.Е., Мокрышева Н.Г., 20222022Воронцов А.В., Бабаева Д.М., Владимирова В.П., Дубовицкая Т.А., Гаврилова А.О., Белая Ж.Е., Мокрышева Н.Г.Vorontsov A.V., Babaeva D.M., Vladimirova V.P., Dubovitskaya T.A., Gavrilova A.O., Belaya Z.E., Mokryshevа N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/12777

В настоящей статье представлен обзор литературы, посвященный особенностям клинического течения различных форм гипофизита, а также проблемам лучевой диагностики и лечения данной патологии. Гипофизит является малоизученным и многофакторным заболеванием, сложность диагностики которого обусловлена не только разнообразными неспецифическими клиническими проявлениями, данными гормонального исследования, но и неоднозначными результатами МРТ-исследования, отсутствием четких МР-паттернов. Данный обзор посвящен современным представлениям о клиническом течении гипофизитов, представлен набор характерных диагностических признаков заболевания по данным МРТ, также освещены рекомендуемые на сегодняшний день алгоритмы лечения. В статье обобщены данные зарубежной литературы и собственные клинические наблюдения с целью выработать оптимальный протокол МРТ-исследования у пациентов с подозрением на гипофизит, рекомендации для врачей-рентгенологов и эндокринологов для правильной интерпретации полученных результатов. Уникальностью данного обзора является отсутствие на сегодняшний день в российской литературе данных о клинической картине, диагностике и лечении гипофизита.

This article presents a literature review of the various forms of hypophysitis, its varieties, as well as the problem of radiation diagnosis and treatment of this pathology. Hypophysitis is a poorly understood and multifactorial disease which the difficulty of diagnosing is not only to a variety of nonspecific clinical manifestations and hormonal research data, but also the ambiguous results of MRI studies, the lack of clear MR patterns. The article reflects the main histological types of hypophysitis, the peculiarities of diagnosis in connection with general clinical symptoms, outlines the features of each type of hypophysitis with their own clinical observations. This review is devoted to modern ideas about the clinical course of hypophysitis, presented a set of characteristic diagnostic signs of the disease according to MRI and the treatment algorithms recommended today are also highlighted. The article summarizes data from foreign literature and our own clinical observations in order to develop an optimal protocol for MRI studies in patients with suspected hypophysitis, to develop recommendations for radiologists and endocrinologists for the correct results interpretation. The uniqueness of this review is the lack of data on the clinic, diagnosis and treatment of hypophysitis in the Russian literature today.

гипофизитмагнитно-резонансная томографиявоспалительное заболевание гипофизалимфоцитарное воспалениеhypophisitismagnetic resonance imaginginflammatory disease of pituitary glandlymphocytic inflammationKluczyński Łukasz Gilis-Januszewska Aleksandra Rogoziński Damian Pantofliński Jacek Hubalewska-Dydejczyk Alicja Hypophysitis — new insights into diagnosis and treatment Endokrynologia Polska 2019 07 260 269 70 3 10.5603/ep.a2019.0015Yukina Marina Yu. Troshina Ekaterina A. Platonova Nadezhda M. Nuralieva Nurana F. The autoimmune IgG4 -associated endocrine pathology Obesity and metabolism 2017 11 43 47 14 3 10.14341/omet2017343-47Joshi Mamta N Whitelaw Benjamin C Carroll Paul V MECHANISMS IN ENDOCRINOLOGY: Hypophysitis: diagnosis and treatment European Journal of Endocrinology 2018 06 R151 R163 179 3 10.1530/eje-17-0009Gubbi Sriram Hannah-Shmouni Fady Verbalis Joseph G. Koch Christian A. Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary inflammation Best Practice & Research Clinical Endocrinology & Metabolism 2019 12 101371 33 6 10.1016/j.beem.2019.101371Vorontsov A.V., Vladimirova V.P., Babaeva D.M. Magnitno-rezonansnaya tomografiya v diagnostike endokrinnykh zabolevanii / Pod red. I.I. Dedova. — M.: OOO Meditsinskoe informatsionnoe agentstvo; 2021. 308 s.Kurokawa R. Ota Y. Gonoi W. Hagiwara A. Kurokawa M. Mori H. Maeda E. Amemiya S. Usui Y. Sato N. Nakata Y. Moritani T. Abe O. MRI Findings of Immune Checkpoint Inhibitor–Induced Hypophysitis: Possible Association with Fibrosis American Journal of Neuroradiology 2020 08 10.3174/ajnr.a6692Naran J, Can AS. Lymphocytic Hypophysitis. [Updated 2020 Nov 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [cited 2021 Jan]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562255/Gutenberg A. Larsen J. Lupi I. Rohde V. Caturegli P. A Radiologic Score to Distinguish Autoimmune Hypophysitis from Nonsecreting Pituitary Adenoma Preoperatively American Journal of Neuroradiology 2009 07 1766 1772 30 9 10.3174/ajnr.a1714Prete A, Salvatori R. Hypophysitis. [Updated 2021 Oct 15]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000.Bellastella G, Maiorino MI, Bizzarro A, et al. Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects. Pituitary. 2016;19(6):625-642. doi: https://doi.org/10.1007/s11102-016-0736-zCaputo Carmela Bazargan Ali McKelvie Penelope A. Sutherland Tom Su Charles S. Inder Warrick J. 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Lymphocytic adenohypophysitis: skull radiographs and MRI Neuroradiology 2002 08 114 120 40 2 10.1007/s002340050550Sahin Serdar Korkmaz Ozge Polat Ozkaya Hande Mefkure Apaydin Tugce Durmaz Emine Sebnem Haliloglu Ozlem Durcan Emre Kadioglu Pinar Primary hypophysitis: Experience of a Single Tertiary Center Experimental and Clinical Endocrinology & Diabetes 2019 06 14 21 129 01 10.1055/a-0919-4388GUO SONGXUE WANG CHAOHUI ZHANG JIANMIN TIAN YONG WU QUN Diagnosis and management of tumor-like hypophysitis: A retrospective case series Oncology Letters 2015 12 1315 1320 11 2 10.3892/ol.2015.4046Sahin Serdar Korkmaz Ozge Polat Ozkaya Hande Mefkure Apaydin Tugce Durmaz Emine Sebnem Haliloglu Ozlem Durcan Emre Kadioglu Pinar Primary hypophysitis: Experience of a Single Tertiary Center Experimental and Clinical Endocrinology & Diabetes 2019 06 14 21 129 01 10.1055/a-0919-4388Joshi Mamta N Whitelaw Benjamin C Carroll Paul V MECHANISMS IN ENDOCRINOLOGY: Hypophysitis: diagnosis and treatment European Journal of Endocrinology 2018 06 R151 R163 179 3 10.1530/eje-17-0009Honegger Jürgen Buchfelder Michael Schlaffer Sven Droste Michael Werner Sandy Strasburger Christian Störmann Sylvère Schopohl Jochen Kacheva Stella Deutschbein Timo Stalla Günter Flitsch Jörg Milian Monika Petersenn Stephan Treatment of Primary Hypophysitis in Germany The Journal of Clinical Endocrinology & Metabolism 2015 06 3460 3469 100 9 10.1210/jc.2015-2146

The authors declare that there are no conflicts of interest present.