problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl12805problendo-12805Research ArticleБолезни костной и жировой тканиBones & Adipose tissues diseasesАдипоцитокины: современный взгляд на дефиницию, классификацию и роль в организмеAdipocytokines: modern definition, classification and physiological rolehttps://orcid.org/0000-0002-8798-887XМарковаТ. Н.MarkovaT. N.

Маркова Татьяна Николаевна, доктор медицинских наук, профессор 

SPIN-код: 5914-2890

123182, Москва, ул. Пехотная, д. 3 

Tatyana N. Markova, MD, PhD, Professor

3 Pehotnaja street, 123182 Moscow

markovatn18@yandex.ruhttps://orcid.org/0000-0001-8270-5626МищенкоН. К.MishchenkoN. K.

Мищенко Надежда Константиновна, аспирант, врач-эндокринолог 

SPIN-код: 1975-9680

Москва

Nadezhda K. Mishchenko, PhD student, endocrinologist

Moscow

koc-nadushka@yandex.ruhttps://orcid.org/0000-0002-6603-5041ПетинаД. В.PetinaD. V.

Петина Диана Викторовна, врач-эндокринолог 

SPIN-код: 7224-3114

Москва

 

Diana V. Petina, endocrinologist

Moscow

doctor_di93@mail.ruГородская клиническая больница №52 Департамента здравоохранения города Москвы; Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияCity Clinical Hospital №52; Moscow State University of Medicine and Dentistry named after A.I. EvdokimovRussian FederationМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияMoscow State University of Medicine and Dentistry named after A.I. EvdokimovRussian FederationГородская клиническая больница №52 Департамента здравоохранения города МосквыРоссияCity Clinical Hospital №52Russian Federation2022061220216817380Copyright © Маркова Т.Н., Мищенко Н.К., Петина Д.В., 20222022Маркова Т.Н., Мищенко Н.К., Петина Д.В.Markova T.N., Mishchenko N.K., Petina D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/12805

Жировая ткань является эндокринным органом, синтезирующим большое количество биологически активных веществ — адипоцитокинов, влияющих на инсулинорезистентность (ИР), метаболизм глюкозы и липидов, процессы ангиогенеза и воспаления. Данные многочисленных исследований показывают тесную связь дисбаланса адипоцитокинов, формирующегося при избыточном отложении жировой ткани, с развитием сахарного диабета 2 типа и сердечно-сосудистых заболеваний. В статье представлен обзор современной литературы, обобщающий данные о воздействии адипоцитокинов на печень, скелетные мышцы, жировую ткань, эндотелиальные клетки и процессы воспаления, а также представлена попытка дефиниции термина «адипоцитокины» и классификации адипоцитокинов с позиции их влияния на метаболические сдвиги и провоспалительный статус. Представители адипоцитокинов (адипонектин, оментин, лептин, резистин, фактор некроза опухоли-α и интерлейкин-6) разделены на две группы: адипоцитокины, снижающие ИР, и адипоцитокины, повышающие ИР.

Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR.

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The authors declare that there are no conflicts of interest present.