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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl12806</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-12806</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Проблема применения гормональной терапии, направленной на коррекцию пола, трансгендерными лицами по собственной инициативе</article-title><trans-title-group xml:lang="en"><trans-title>The problem of the use of hormonal therapy aimed for sex correction by transgender persons on their own initiative</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3767-8475</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макарова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макарова Екатерина Владимировна, кандидат медицинских наук, врач-эндокринолог, старший научный сотрудник</p><p>105082, г. Москва, ул. Большая Почтовая, д. 20, стр. 3, пом. 3–17</p><p>Scopus Author ID: 57201075018; </p><p>eLibrary SPIN: 1305-6152</p></bio><bio xml:lang="en"><p>Ekaterina V. Makarova, PhD</p><p>Bolshaya Pochtovaya st., 20, building 3, rooms 3–17, 105082 Moscow</p><p>SPIN-код: 1305-6152</p></bio><email xlink:type="simple">rue-royal@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2965-9127</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovieva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьева Надежда Валентиновна, директор центра, врач-психиатр</p><p>Москва</p><p>eLibrary SPIN: 2345-2467</p></bio><bio xml:lang="en"><p>Nadezhda V. Solovieva</p><p>Moscow</p><p>SPIN-код: 2345-2467</p></bio><email xlink:type="simple">drsnv@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0047-0291</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кременицкая</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kremenitskaya</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кременицкая Светлана Анатольевна </p><p>Москва</p><p>SPIN-код: 7370-2385</p></bio><bio xml:lang="en"><p>Svetlana A. Kremenitskaya</p><p>Moscow</p><p>SPIN-код: 7370-2385</p></bio><email xlink:type="simple">kremenickaya@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр персонализированной медицины;&#13;
Национальный научно-исследовательский институт общественного здоровья им. Н.А. Семашко</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Personalized Medicine;&#13;
N.A. Semashko National Research Institute of Public Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научный центр персонализированной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Personalized Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>04</month><year>2022</year></pub-date><volume>68</volume><issue>2</issue><fpage>40</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Макарова Е.В., Соловьева Н.В., Кременицкая С.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Макарова Е.В., Соловьева Н.В., Кременицкая С.А.</copyright-holder><copyright-holder xml:lang="en">Makarova E.V., Solovieva N.V., Kremenitskaya S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/12806">https://www.probl-endojournals.ru/jour/article/view/12806</self-uri><abstract><sec><title>ВВЕДЕНИЕ</title><p>ВВЕДЕНИЕ. В последние годы значимо возрос запрос на феминизирующую и маскулинизирующую гормональную терапию среди трансгендерных людей во всем мире. В России отсутствуют подобные исследования, и количество медицинской информации о популяции трансгендерных лиц ограничено.</p></sec><sec><title>ЦЕЛЬ</title><p>ЦЕЛЬ. Оценить количество трансгендерных пациентов, которые принимают гормональную терапию без назначения врача, а также дать характеристику используемым ими препаратам.</p></sec><sec><title>МАТЕРИАЛЫ И МЕТОДЫ</title><p>МАТЕРИАЛЫ И МЕТОДЫ. В анализ были включены данные 1117 трансгендерных пациентов (44,01% (n=515) из них были трансгендерными женщинами, 55,99% (n=630) были трансгендерными мужчинами), обратившихся в «Научный центр персонализированной медицины» с целью получения медицинской помощи.</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ. На момент обращения за медицинской помощью половина трансгендерных пациентов (53,6%) уже принимали гормональные препараты — чаще трансгендерные женщины (76,7%), реже трансгендерные мужчины (32,3%). К эндокринологам за назначением терапии при этом обращались только 8,6% из них. Многие пациенты применяют нелицензированные средства, используют нерациональные схемы и комбинации, зачастую встречается передозировка.</p></sec><sec><title>ЗАКЛЮЧЕНИЕ</title><p>ЗАКЛЮЧЕНИЕ. Значительная часть трансгендерных людей начинают применять заместительную гормональную терапию по собственной инициативе, без контроля врачей. Решением данной проблемы могли бы быть повышение уровня знаний врачей и пациентов для формирования доверительной среды и продуктивного взаимодействия между терапевтами, эндокринологами и трансгендерными людьми, а также организация консультативных центров в рамках государственных медицинских учреждений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>BACKGROUND</title><p>BACKGROUND: In recent years, the demand for feminizing and masculinizing hormone therapy has increased significantly among transgender people around the world. There are no such studies in Russia and the amount of medical information on the transgender population is limited.</p></sec><sec><title>AIM</title><p>AIM: to assess the number of transgender patients who take hormone therapy without a doctor’s prescription and to characterize the medicines they use.</p></sec><sec><title>MATERIALS AND METHODS</title><p>MATERIALS AND METHODS: data from 1117 transgender patients were included in to analysis: 44.01% (n=515) of them were trans women, 55.99% (n=630) were trans men. Patients applied to the “Scientific Center for Personalized Medicine” in order to receive medical care.</p></sec><sec><title>RESULTS</title><p>RESULTS: Half of transgender people (53.6%) are already taking hormonal drugs. More often transgender women (76.7%), less often transgender men (32.3%). In this case, only 8.6% turned to endocrinologists for the therapy prescription. Many patients used unlicensed drugs, use irrational schemes and combinations, often overdose.</p></sec><sec><title>CONCLUSION</title><p>CONCLUSION: A significant number of transgender people start using hormone replacement therapy on their own initiative, without the doctor’s supervision. The solution to this problem could be incensement of knowledge level in doctors and patients to create a friendly environment and productive interaction between therapists, endocrinologists and transgender people, as well as the organization of consulting centers within public medical institutions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансгендерное здоровье</kwd><kwd>заместительная гормональная терапия</kwd><kwd>тестостерон</kwd><kwd>эстрогены</kwd><kwd>маскулинизация</kwd><kwd>феминизация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>transgender health</kwd><kwd>hormone replacement therapy</kwd><kwd>testosterone</kwd><kwd>estrogens</kwd><kwd>masculinization</kwd><kwd>feminization</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">-</funding-statement></funding-group></article-meta></front><back><ref-list><ref id="cit1"><element-citation><name><surname>Nolan</surname> <given-names>Ian T.</given-names> </name> <name><surname>Kuhner</surname> <given-names>Christopher J.</given-names> </name> <name><surname>Dy</surname> <given-names>Geolani W.</given-names> </name> <article-title>Demographic and temporal trends in transgender identities and gender confirming surgery</article-title> <source>Translational Andrology and Urology</source> <year>2019</year> <month>06</month> <fpage>184</fpage> <lpage>190</lpage> <volume>8</volume> <issue>3</issue> <object-id pub-id-type="doi" specific-use="metadata">10.21037/tau.2019.04.09</object-id></element-citation></ref><ref id="cit2"><element-citation><name><surname>Solov’eva</surname> <given-names>N. 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