problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13078problendo-13078Research ArticleБолезни костной и жировой тканиBones & Adipose tissues diseasesПитание, ограниченное по времени, как новая стратегия терапии ожирения и коморбидных состоянийTime-restricted eating as a novel strategy for treatment of obesity and it’s comorbid conditionshttps://orcid.org/0000-0003-4974-7765БерковскаяМ. А.BerkovskayaM. A.

Берковская Марина Ароновна – кандидат медицинских наук, кафедра эндокринологии №1.

119435, Москва, ул. Погодинская, д. 1.

SPIN-код: 4251-7117

Marina A. Berkovskaya - MD, PhD.

1 Pogodinskaya street, 119435 Moscow.

SPIN-код: 4251-7117

abaitamar@gmail.comhttps://orcid.org/0000-0003-2576-4421ГуроваО. Ю.GurovaO. Y.

Гурова Олеся Юрьевна - кандидат медицинских наук, кафедра эндокринологии №1.

119435, Москва, ул. Погодинская, д. 1.

SPIN-код: 1257-5499

Olesya Yu. Gurova - MD, PhD.

1 Pogodinskaya street, 119435 Moscow.

SPIN-код: 1257-5499

gurova79@inbox.ruhttps://orcid.org/0000-0003-3508-7559ХайкинаИ. А.KhaykinaI. A.

Хайкина Ирина Анатольевна - кафедра эндокринологии №1.

119435, Москва, ул. Погодинская, д. 1.

Irina A. Khaykina - MD.

1 Pogodinskaya street, 119435 Moscow.

iakhaykina@gmail.comhttps://orcid.org/0000-0002-3026-6315ФадеевВ. В.FadeevV. V.

Фадеев Валентин Викторович – доктор медицинских наук, профессор, член-корреспондент РАН.

119435, Москва, ул. Погодинская, д. 1.

SPIN-код: 6825-8417

Valentin V. Fadeev - MD, ScD, professor, corresponding member of the RAS.

1 Pogodinskaya street, 119435 Moscow.

SPIN-код: 6825-8417

walfad@mail.ruПервый Московский государственный медицинский университет имени И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation2022010620226847891Copyright © Берковская М.А., Гурова О.Ю., Хайкина И.А., Фадеев В.В., 20222022Берковская М.А., Гурова О.Ю., Хайкина И.А., Фадеев В.В.Berkovskaya M.A., Gurova O.Y., Khaykina I.A., Fadeev V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13078

Настоящая рукопись представляет обзор современной литературы, посвященной изучению питания, ограниченного по времени (ПОВ), как инструмента лечения ожирения и коморбидных состояний. Поиск новых пищевых стратегий лечения ожирения, одной из которых является ПОВ, обусловлен слабой приверженностью пациентов гипокалорийным диетам в долгосрочной перспективе, а также имеющимися данными о важной роли десинхронизации приема пищи с естественными циркадианными ритмами в развитии и прогрессировании ожирения и кардиометаболических осложнений. В статье описываются основные механизмы, регулирующие циркадианные ритмы приема пищи и усвоения нутриентов, обосновывается важность соблюдения физиологического режима питания для поддержания метаболического здоровья. Основная часть обзора посвящена рассмотрению имеющихся на сегодняшний день исследований эффективности различных стратегий прерывистого ограничения энергии для снижения массы тела и коррекции метаболических показателей. Обсуждаются потенциальные механизмы влияния ПОВ на здоровье, в том числе опосредованные непреднамеренным снижением калорийности рациона и изменением пищевого поведения, различия в эффективности раннего и позднего ПОВ. Статья содержит подробное обсуждение потенциальных проблем и противоречий, связанных с внедрением питания, ограниченного по времени, в клиническую практику, а именно: ограниченность и противоречивость имеющихся клинических исследований, отсутствие данных о долгосрочной эффективности и безопасности, социальные и психологические ограничения, затрудняющие широкое использование ПОВ.

The article provides a review of the current literature about time-restricted eating (TRE) as a new tool for the treatment of obesity and comorbid conditions. The search for new nutritional strategies in obesity, one of which is TRE, is due to the weak adherence of patients to hypocaloric diets in the long term, as well as the available data on the importance of ­desynchronization of food intake with natural circadian rhythms in the development and progression of obesity and cardio-­metabolic complications. The article describes the main mechanisms that regulate the circadian rhythms of food intake and nutrient absorption, substantiates the importance of adhering to a physiological diet for maintaining metabolic health. The main part of the review is devoted to reviewing the currently available researches on the effectiveness of various strategies of intermittent energy restriction for weight loss and the correction of metabolic parameters. Potential mechanisms of  the ­effect of TRE on health are discussed, including those mediated by an unintentional decrease in caloric intake and changes in eating behavior, and differences in the effectiveness of early and late TRE. The article contains a detailed discussion of the potential problems and contradictions associated with the use of time-restricted eating in clinical practice, namely: the limitations and inconsistencies of the available clinical trials, the lack of data on long-term efficacy and safety, social and psychological limitations that impede the widespread use of TRE.

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The authors declare that there are no conflicts of interest present.