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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl13103</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-13103</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Диагностика и тактика ведения пациента с центральным несахарным диабетом на примере клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and tactics of managing a patient with central diabetes insipidus on the example of a clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2094-8731</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катамадзе</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Katamadze</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Катамадзе Нино Николаевна.</p><p>117036, Москва, ул. Дмитрия Ульянова, д. 11, к. 2.</p><p>SPIN-код: 6755-9320</p></bio><bio xml:lang="en"><p>Nino N. Katamadze.</p><p>Dmitry Ulyanova street 11 bld 2, 117036 Moscow.</p><p>SPIN-код: 6755-9320</p></bio><email xlink:type="simple">nincho.1994@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6539-466X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пигарова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pigarova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пигарова Екатерина Александровна - доктор медицинских наук.</p><p>Москва.</p><p>SPIN-код: 6912-6331</p></bio><bio xml:lang="en"><p>Ekaterina A. Pigarova - MD, PhD.</p><p>Moscow.</p><p>SPIN-код: 6912-6331</p></bio><email xlink:type="simple">kpigarova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0327-4619</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзеранова</surname><given-names>Л. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzeranova</surname><given-names>L. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дзеранова Лариса Константиновна – доктор медицинских наук.</p><p>Москва.</p><p>SPIN-код: 2958-5555</p></bio><bio xml:lang="en"><p>Larisa K. Dzeranova.</p><p>Moscow.</p><p>SPIN-код: 2958-5555</p></bio><email xlink:type="simple">dzeranovalk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр эндокринологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>07</month><year>2022</year></pub-date><volume>68</volume><issue>5</issue><fpage>39</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Катамадзе Н.Н., Пигарова Е.А., Дзеранова Л.К., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Катамадзе Н.Н., Пигарова Е.А., Дзеранова Л.К.</copyright-holder><copyright-holder xml:lang="en">Katamadze N.N., Pigarova E.A., Dzeranova L.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/13103">https://www.probl-endojournals.ru/jour/article/view/13103</self-uri><abstract><p>Диагностика и дифференциальная диагностика пациентов с несахарным диабетом нередко представляют собой сложную задачу для врачей различных специальностей. Данный клинический случай посвящен описанию пациента с длительным анамнезом идиопатического несахарного диабета центрального генеза, у которого резко снизилась потребность в десмопрессине за последний год наблюдения. Проведение проб с осмотической стимуляцией (тест с водной депривацией, инфузионная проба с гипертоническим раствором) позволило ответить на вопрос о сохранении заболевания, а также определить дальнейший план ведения с учетом физиологических особенностей.</p></abstract><trans-abstract xml:lang="en"><p>Diagnosis and differential diagnosis of patients with diabetes insipidus is often a difficult task for the endocrinologist. This case report focuses on a patient with a long history of central idiopathic diabetes insipidus who had a substantial decrease in desmopressin requirements during the last year of follow-up. Conducting tests with osmotic stimulation (test with water deprivation, infusion test with hypertonic solution) made it possible to answer the question of the persistence of the disease, as well as to determine a further management plan, taking into account the physiological characteristics of our patient.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>несахарный диабет</kwd><kwd>десмопрессин</kwd><kwd>проба с гипертоническим раствором</kwd><kwd>тест с водной депривацией</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diabetes insipidus</kwd><kwd>desmopressin</kwd><kwd>hypertonic saline test</kwd><kwd>water deprivation test</kwd></kwd-group></article-meta></front><back><ref-list><ref id="cit1"><element-citation><name><surname>Dedov</surname> <given-names>Ivan I.</given-names> </name> <name><surname>Mel'nichenko</surname> <given-names>Galina A.</given-names> </name> <name><surname>Pigarova</surname> <given-names>Ekaterina A.</given-names> </name> <name><surname>Dzeranova</surname> 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