problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13214problendo-13214Research ArticleКлиническая эндокринологияClinical endocrinologyОсобенности водно-электролитного баланса у лиц старшей возрастной группFeatures of water-electrolyte balance in persons of the older age grouphttps://orcid.org/0000-0003-2094-8731КатамадзеН. Н.KatamadzeN. N.

Катамадзе Нино Николаевна

117036, Москва, ул. Дмитрия Ульянова, д. 11, к. 2

Nino N. Katamadze]

Dmitry Ulyanova street 11, bld. 2, 117036 Moscow

nincho.1994@mail.ruhttps://orcid.org/0000-0001-6539-466XПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна - д.м.н.

Москва

Ekaterina A. Pigarova - MD, PhD.

Moscow

kpigarova@gmail.comhttps://orcid.org/0000-0002-0327-4619ДзерановаЛ. К.DzeranovaL. K.

Дзеранова Лариса Константиновна - д.м.н.

Москва

Larisa K. Dzeranova - MD, PhD.

Moscow

dzeranovalk@yandex.ruhttps://orcid.org/0000-0002-9717-9742МокрышеваН. Г.MokryshevaN. G.

Мокрышева Наталья Георгиевна - д.м.н., профессор.

Москва

Natalia G. Mokrysheva - MD, PhD, Professor.

Moscow

parathyroid.enc@gmail.comНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2023240120246962836Copyright © Катамадзе Н.Н., Пигарова Е.А., Дзеранова Л.К., Мокрышева Н.Г., 20242024Катамадзе Н.Н., Пигарова Е.А., Дзеранова Л.К., Мокрышева Н.Г.Katamadze N.N., Pigarova E.A., Dzeranova L.K., Mokrysheva N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13214

Возрастные изменения оказывают большое влияние на регуляцию водно-электролитного гомеостаза в организме, который управляется сложным взаимодействием факторов окружающей среды, питьевым поведением, секрецией ряда гормонов и гормоноподобных веществ, а также иннервацией и функциональным состоянием почек. Хорошо известно, что изменения, которые являются частью физиологического старения, лежат в основе нарушений водно-электролитного баланса, что усугубляется наличием возраст-ассоциированных заболеваний, приемом лекарственных препаратов или рядом внешних факторов, таких как неполноценное питание, потребление жидкости, наличие деменции. В данном обзоре рассмотрены данные литературы по влиянию нормального старения на развитие патологии водно-натриевого баланса, включая дегидратацию пациентов старческого возраста, гипонатриемию, гипернатриемию, изменения секреции антидиуретического гормона и активности элементов ренин-ангиотензин-альдостероновой системы.

Age-related changes have a great influence on the regulation of water and electrolyte homeostasis in the body, which is regulated by a complex interaction of environmental factors, drinking behavior, the secretion of a number of hormones and hormone-like substances, as well as the innervation and functional state of the kidneys. It is well known that the changes that are part of physiological aging underlie fluid and electrolyte imbalances, exacerbated by the presence of age-related diseases, medications, or a number of external factors such as malnutrition, fluid intake, and the presence of dementia. This review considers literature data on the effect of normal aging on the development of pathology of the water-sodium balance, including dehydration of senile patients, hyponatremia, hypernatremia, changes in the secretion of antidiuretic hormone and the activity of elements of the renin-angiotensin-aldosterone system.

водно-электролитный обменгипонатриемиягипернатриемияантидиуретический гормонАДГренинальдостеронРААСстарческий возрастстарениеwater and electrolyte metabolismhyponatremiahypernatremiaantidiuretic hormoneADHreninaldosteroneRAASagingРабота выполнена по инициативе авторов без привлечения финансированияThunhorst Robert L. Beltz Terry Johnson Alan Kim Age-related declines in thirst and salt appetite responses in male Fischer 344×Brown Norway rats Physiology & Behavior 2014 06 180 188 135 10.1016/j.physbeh.2014.06.010Liamis George Rodenburg Eline M. Hofman Albert Zietse Robert Stricker Bruno H. Hoorn Ewout J. Electrolyte Disorders in Community Subjects: Prevalence and Risk Factors The American Journal of Medicine 2013 01 256 263 126 3 10.1016/j.amjmed.2012.06.037Wong LL, Verbalis JG. Systemic diseases associated with disorders of water homeostasis. Endocrinol Metab Clin North Am. 2002;31(1):121-140. doi: https://doi.org/10.1016/s08898529(01)00007-xMadsen Steffen S. Engelund Morten B. Cutler Christopher P. Water Transport and Functional Dynamics of Aquaporins in Osmoregulatory Organs of Fishes The Biological Bulletin 2016 09 70 92 229 1 10.1086/bblv229n1p70Schlander LE. Vasopressin in the kidney — historical aspects. Chapter 5. In: Schlander LE, Sands JM, editors. Textbook of Nephro-Endocrinology. Second edition. Elsevier Inc; 2018. P. 77-93.Bourque C.W. Oliet S.H.R. Richard D. Osmoreceptors, Osmoreception, and Osmoregulation Frontiers in Neuroendocrinology 2002 09 231 274 15 3 10.1006/frne.1994.1010Chapman FA, Nyimanu D, Maguire JJ, et al. The therapeutic potential of apelin in kidney disease. Nat Rev Nephrol. 2021;17(12):840-853. doi: https://doi.org/10.1038/s41581-021-00461-zLiu F Y Cogan M G Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics. Journal of Clinical Investigation 2008 02 601 607 82 2 10.1172/jci113638Williams GH. Chapter 336: Disorders of the adrenal cortex. In: Williams GH, Dluhy RG, Loscalzo J, et al, editors. Harrison’s principles of internal medicine. McGraw-Hill Medical; 2008.Epstein Alan N. Mineralocorticoids and cerebral angiotensin may act together to produce sodium appetite Peptides 2003 02 493 494 3 3 10.1016/0196-9781(82)90113-9Scott JH, Menouar MA, Dunn RJ. Physiology, aldosterone. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.Theilig Franziska Wu Qingyu ANP-induced signaling cascade and its implications in renal pathophysiology American Journal of Physiology-Renal Physiology 2015 01 F1047 F1055 308 10 10.1152/ajprenal.00164.2014McLachlan M. Wasserman P. Changes in sizes and distensibility of the aging kidney The British Journal of Radiology 2009 07 488 491 54 642 10.1259/0007-1285-54-642-488Kremers Walter K. Denic Aleksandar Lieske John C. Alexander Mariam P. Kaushik Vidhu Elsherbiny Hisham E. Chakkera Harini A. Poggio Emilio D. Rule Andrew D. Distinguishing age-related from disease-related glomerulosclerosis on kidney biopsy: the Aging Kidney Anatomy study Nephrology Dialysis Transplantation 2015 04 2034 2039 30 12 10.1093/ndt/gfv072Dabo S. M. Taylor J. D. Confer A. W. Pasteurella multocidaand bovine respiratory disease Animal Health Research Reviews 2008 01 129 150 8 2 10.1017/s1466252307001399Frassetto L. Sebastian A. Age and Systemic Acid-Base Equilibrium: Analysis of Published Data The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2011 06 B91 B99 51A 1 10.1093/gerona/51a.1.b91Glassock Richard J. Rule Andrew D. Aging and the Kidneys: Anatomy, Physiology and Consequences for Defining Chronic Kidney Disease Nephron 2016 04 25 29 134 1 10.1159/000445450Sands Jeff M. Layton Harold E. The Physiology of Urinary Concentration: An Update Seminars in Nephrology 2009 06 178 195 29 3 10.1016/j.semnephrol.2009.03.008Schlanger Lynn E. Sands Jeff M. Vasopressin in the Kidney: Historical Aspects Textbook of Nephro-Endocrinology 2009 02 203 223 10.1016/b978-0-12-373870-7.00016-8Klein Janet D. Sands Jeff M. Qian Liman Wang Xiaodan Yang Baoxue Upregulation of Urea Transporter UT-A2 and Water Channels AQP2 and AQP3 in Mice Lacking Urea Transporter UT-B Journal of the American Society of Nephrology 2004 10 1161 1167 15 5 10.1097/01.asn.0000125617.19799.72Díez Javier Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy European Journal of Heart Failure 2016 10 167 176 19 2 10.1002/ejhf.656Schalekamp M. A. D. H. Krauss X. H. Schalekamp-Kuyken M. P. A. Kolsters G. Birkenhäger W. H. Studies on the Mechanism of Hypernatriuresis in Essential Hypertension in Relation to Measurements of Plasma Renin Concentration, Body Fluid Compartments and Renal Function Clinical Science 2015 08 219 231 41 3 10.1042/cs0410219Helderman J. H. Vestal R. E. Rowe J. W. Tobin J. D. Andres R. Robertson G. L. The Response of Arginine Vasopressin to Intravenous Ethanol and Hypertonic Saline in Man: The Impact of Aging Journal of Gerontology 2012 11 39 47 33 1 10.1093/geronj/33.1.39DAVIES IOAN O'NEILL PAUL A. MCLEAN KATHLEEN A. CATANIA JAMES BENNETT DEREK Age-associated Alterations in Thirst and Arginine Vasopressin in Response to a Water or Sodium Load Age and Ageing 2007 01 151 159 24 2 10.1093/ageing/24.2.151Frolkis Vladimir V. Kvitnitskaya-Ryzhova Tatiana Yu. Martynenko Olga A. Aging of neurons in the mollusc Lymnaea stagnalis small parietal ganglion: a morpho-functional comparison in the same neuron Experimental Gerontology 2002 07 533 544 30 5 10.1016/0531-5565(95)00008-5Effect of age and testosterone on the vasopressin and aquaporinresponses to dehydration in Fischer 344/Brown-Norway F1 rats The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2011 06 B26 B34 55 1 10.1093/gerona/55.1.b26Nakama Chikako Kamide Kei Kawai Tatsuo Hongyo Kazuhiro Ito Norihisa Onishi Miyuki Takeya Yasushi Yamamoto Koichi Sugimoto Ken Rakugi Hiromi The influence of aging on the diagnosis of primary aldosteronism Hypertension Research 2014 08 1062 1067 37 12 10.1038/hr.2014.129NÚÑEZ J. F. MACÍAS IGLESIAS C. GARCÍA ROMÁN A. BONDÍA COMMES J. L. RODRÍGUEZ BECERRA L. CORBACHO ROMO J. M. TABERNERO DE CASTRO DEL POZO S. RENAL HANDLING OF SODIUM IN OLD PEOPLE: A FUNCTIONAL STUDY Age and Ageing 2007 01 178 181 7 3 10.1093/ageing/7.3.178Fernández-Atucha A. Izagirre A. Fraile-Bermúdez A. B. Kortajarena M. Larrinaga G. Martinez-Lage P. Echevarría E Gil J. Sex differences in the aging pattern of renin–angiotensin system serum peptidases Biology of Sex Differences 2017 02 8 1 10.1186/s13293-017-0128-8Smith Diarmuid M. McKenna Kieran Thompson Christopher J. Hyponatraemia Clinical Endocrinology 2003 03 667 678 52 6 10.1046/j.1365-2265.2000.01027.xMiller Myron Hecker Melanie S. Friedlander Deborah A. Carter John M. Apparent Idiopathic Hyponatremia in an Ambulatory Geriatric Population Journal of the American Geriatrics Society 2015 04 404 408 44 4 10.1111/j.1532-5415.1996.tb06410.xMiller M. Hyponatremia: age-related risk factors and therapy decisions. Geriatrics. 1998;53(7):32-33.Rao MY, Sudhir U, Anil Kumar T, et al. Hospital-based descriptive study of symptomatic hyponatremia in elderly patients. J Assoc Physicians India. 2010;(58):667-669.Hoyle Graeme E. Chua Melvin Soiza Roy L. PREVALENCE OF HYPONATREMIA IN ELDERLY PATIENTS Journal of the American Geriatrics Society 2006 09 1473 1473 54 9 10.1111/j.1532-5415.2006.00872.xFilippatos Theodosios D Makri Andromachi Elisaf Moses S Liamis George Hyponatremia in the elderly: challenges and solutions Clinical Interventions in Aging 2017 11 1957 1965 Volume 12 10.2147/cia.s138535Anpalahan Mahesan Chronic Idiopathic Hyponatremia in Older People Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Possibly Related to Aging Journal of the American Geriatrics Society 2002 07 788 792 49 6 10.1046/j.1532-5415.2001.49157.xRenneboog Benoit Musch Wim Vandemergel Xavier Manto Mario U. Decaux Guy Mild Chronic Hyponatremia Is Associated With Falls, Unsteadiness, and Attention Deficits The American Journal of Medicine 2006 01 71.e1 71.e8 119 1 10.1016/j.amjmed.2005.09.026Kinsella Sinead Moran Sarah Sullivan Miriam O. Molloy Michael G.M. Eustace Joseph A. Hyponatremia Independent of Osteoporosis is Associated with Fracture Occurrence Clinical Journal of the American Society of Nephrology 2010 01 275 280 5 2 10.2215/cjn.06120809Nzerue CM, Baffoe-Bonnie H, You W, et al. Predictors of outcome in hospitalized patients with severe hyponatremia. J Natl Med Assoc. 2003;95(5):335-343.Renneboog Benoit Musch Wim Vandemergel Xavier Manto Mario U. Decaux Guy Mild Chronic Hyponatremia Is Associated With Falls, Unsteadiness, and Attention Deficits The American Journal of Medicine 2006 01 71.e1 71.e8 119 1 10.1016/j.amjmed.2005.09.026Gosch Markus Joosten-Gstrein Birgit Heppner Hans-Jürgen Lechleitner Monika Hyponatremia in Geriatric Inhospital Patients: Effects on Results of a Comprehensive Geriatric Assessment Gerontology 2012 06 430 440 58 5 10.1159/000339100Negri Armando Luis Ayus Juan Carlos Hyponatremia and bone disease Reviews in Endocrine and Metabolic Disorders 2016 09 67 78 18 1 10.1007/s11154-016-9387-7Verbalis Joseph G Barsony Julianna Sugimura Yoshihisa Tian Ying Adams Douglas J Carter Elizabeth A Resnick Helaine E Hyponatremia-induced osteoporosis Journal of Bone and Mineral Research 2009 09 554 563 25 3 10.1359/jbmr.090827Hoorn Ewout J Rivadeneira Fernando van Meurs Joyce BJ Ziere Gijsbertus Stricker Bruno HCh Hofman Albert Pols Huibert AP Zietse Robert Uitterlinden André G Zillikens M Carola Mild hyponatremia as a risk factor for fractures: The rotterdam study Journal of Bone and Mineral Research 2011 03 1822 1828 26 8 10.1002/jbmr.380Tolouian Ramin Alhamad Tarek Farazmand Maryam Mulla Zuber D. The correlation of hip fracture and hyponatremia in the elderly Journal of Nephrology 2011 12 789 793 25 5 10.5301/jn.5000064Dzagaxova Agunda V. Katamadze Nino N. Pigarova Ekaterina A. Syndrome of inappropriate secretion of antidiuretic hormone in the practice of endocrinologist Endocrine Surgery 2021 06 4 12 14 3 10.14341/serg12692Faustini-Fustini M. Anagni M. Beyond semantics: Defining hyponatremia in secondary adrenal insufficiency Journal of Endocrinological Investigation 2014 03 267 269 29 3 10.1007/bf03345553Glover Mark Clayton Jenny Thiazide‐Induced Hyponatraemia: Epidemiology and Clues to Pathogenesis Cardiovascular Therapeutics 2011 06 30 5 10.1111/j.1755-5922.2011.00286.xAlon US. The effects of diuretics on mineral and bone metabolism. Pediatr Endocrinol Rev. 2018;15(4):291-297. doi: https://doi.org/10.17458/per.vol15.2018.a.DiureticsMineralBoneMetabolismVerbalis Joseph G. Goldsmith Steven R. Greenberg Arthur Korzelius Cynthia Schrier Robert W. Sterns Richard H. Thompson Christopher J. Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations The American Journal of Medicine 2013 09 S1 S42 126 10 10.1016/j.amjmed.2013.07.006Tzamaloukas Antonios H. Shapiro Joseph I. Raj Dominic S. Murata Glen H. Glew Robert H. Malhotra Deepak Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors? The American Journal of the Medical Sciences 2014 09 432 439 348 5 10.1097/maj.0000000000000331Beck LH. The aging kidney. Defending a delicate balance of fluid and electrolytes. Geriatrics. 2000;55(4):26-32.SNYDER NEAL A. Hypernatremia in Elderly Patients Annals of Internal Medicine 2013 04 309 107 3 10.7326/0003-4819-107-2-309Verbalis Joseph G. Disorders of water metabolism Clinical Neuroendocrinology 2014 09 37 52 10.1016/b978-0-444-59602-4.00003-4Chassagne Philippe Druesne Laurent Capet Corinne Ménard Jean François Bercoff Eric Clinical Presentation of Hypernatremia in Elderly Patients: A Case Control Study Journal of the American Geriatrics Society 2006 07 1225 1230 54 8 10.1111/j.1532-5415.2006.00807.xKim Soo Wan Hypernatemia : Successful Treatment Electrolyte & Blood Pressure 2010 07 66 4 2 10.5049/ebp.2006.4.2.66

The authors declare that there are no conflicts of interest present.