problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13361problendo-13361Research ArticleРедакционная статьяEditorialХронический аутоиммунный тиреоидит — «сигнальное заболевание» в составе мультиорганного аутоиммунного синдромаChronic autoimmune thyroiditis is a «signal disease» in the multiorgan autoimmune syndromehttps://orcid.org/0000-0002-8520-8702ТрошинаЕ. А.TroshinaE. A.

Трошина Екатерина Анатольевна, д.м.н., член-корр. РАН, профессор

 Москва 

Ekaterina A. Troshina, MD, PhD, Professor 

Moscow 

troshina@inbox.ruФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава РоссииРоссияEndocrinology Research CentreRussian Federation202331082023694410Copyright © Трошина Е.А., 20232023Трошина Е.А.Troshina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13361

Текущее столетие объявлено ВОЗ «веком аутоиммунных заболеваний», которых к сегодняшнему дню насчитывается более ста. Естественное течение любого аутоиммунного заболевания характеризуется прогрессированием от латентной и субклинической стадий к клинической и связано с наличием специфических циркулирующих аутоантител. В течение жизни человека с одним верифицированным аутоиммунным заболеванием существует высокая вероятность последовательной манифестации других аутоиммунных патологий. Каждый четвертый пациент с хроническим аутоиммунным тиреоидитом заболевает аутоиммунными нетиреоидными патологиями, и наоборот, среди лиц с нетиреоидными аутоиммунными болезнями часто встречается хронический аутоиммунный тиреоидит. Современные представления о патогенетических механизмах развития и прогрессирования аутоиммунных заболеваний позволяют рассматривать хронический аутоиммунный тиреоидит в качестве «сигнальной патологии» при мультиорганном аутоиммунном синдроме.

The current century has been declared by the WHO as the «century of autoimmune diseases», of which there are more than a hundred today. The natural course of any autoimmune disease is characterized by progression from a latent and subclinical to a clinical stage and is associated with the presence of specific circulating autoantibodies. During the life of a person with one verified autoimmune disease, there is a high probability of consecutive manifestation of other autoimmune pathologies. Every fourth patient with chronic autoimmune thyroiditis develops autoimmune non-thyroid pathologies during his life, and vice versa, chronic autoimmune thyroiditis is present among people with non-thyroid autoimmune diseases. Modern ideas about the pathogenetic mechanisms of the development and progression of autoimmune diseases make it possible to consider chronic autoimmune thyroiditis as a «signal pathology» in the multiorgan autoimmune syndrome.

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The authors declare that there are no conflicts of interest present.