problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13397problendo-13397Research ArticleРепродуктивная эндокринологияReproductive EndocrinologyРоль лептина в развитии патологии эндометрия: литературный обзорThe role of leptin in endometrium disorders: literature reviewhttps://orcid.org/0000-0002-0177-234XИевлеваК. Д.IevlevaK. D.

Иевлева Ксения Дмитриевна - к.м.н.

664003, Иркутск, ул. Тимирязева, 16

Ievleva Kseniia Dmitrievna - Can. of Med. Sc.

664003, , 16 Timiryezev st.

asiy91@mail.ruhttps://orcid.org/0000-0002-8862-5771ДанусевичИ. Н.DanusevichI. N.

Данусевич Ирина Николаевна - д.м.н.

Иркутск

Danusevich Irina Nicolaevna - Doc. of Med. Sc.

Irkutsk

irinaemails@gmail.comhttps://orcid.org/0000-0002-6271-7803СутуринаЛ. В.SuturinaL. V.

Suturina Larisa Victorovna - professor, Doc. of Med. Sc.

Irkutsk

Suturina Larisa Victorovna - professor, Doc. of Med. Sc.

Irkutsk

lsuturina@mail.ruНаучный центр проблем здоровья семьи и репродукции человекаРоссияScientific Centre for Family Health and Human ReproductionRussian Federation202405112024705106114Copyright © Иевлева К.Д., Данусевич И.Н., Сутурина Л.В., 20242024Иевлева К.Д., Данусевич И.Н., Сутурина Л.В.Ievleva K.D., Danusevich I.N., Suturina L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13397

Лептин является не только главным регулятором энергетического баланса в организме, но также оказывает влияние на репродуктивную и иммунную систему. Лептин и его рецепторы экспрессируются в эндометрии, активно участвуя в процессе имплантации эмбриона. По данным многочисленных исследований, изменение экспрессии и уровня лептина ассоциировано с развитием воспалительных и аутоиммунных заболеваний, в том числе эндометриоза и хронического эндометрита. Гиперпластические и воспалительные заболевания матки сопровождаются нарушением рецептивности эндометрия за счет дисрегуляции множества факторов, участвующих в процессах пролиферации, васкуляризации и децидуализации клеток. Функциональная активность большинства из этих факторов обусловлена действием лептина, однако к настоящему моменту отсутствуют исследования прямой роли лептина в патогенезе нарушений функционального состояния эндометрия при гиперпластических и воспалительных заболеваниях органов малого таза.

Таким образом, цель настоящего литературного обзора — описать предполагаемые молекулярные механизмы влияния лептина на развитие патологии эндометрия.

Литературный поиск проводился в период с 20.03.2023 по 11.05.2023 с использованием баз научной литературы: NCBI PubMed, Google Scholar (зарубежные источники), Киберленинка, Elibrary (отечественные источники), анализировались литературные источники за период 1995-2023 гг. Для поиска использовались следующие ключевые слова: лептин, эндометриальная дисфункция, эндометриальная рецептивность, воспаление, воспалительные заболевания органов малого таза.

Leptin is not only the main regulator of energy balance, but also it affects the reproductive and immune systems. Leptin and its receptors are expressed in the endometrium and are actively involved in the embryo implantation. According to numerous studies, expression and level changes of leptin are associated with the inflammatory and autoimmune diseases, including endometriosis and chronic endometritis. Hyperplastic and inflammatory diseases of the uterus are accompanied by a violation of the receptivity of the endometrium due to the dysregulation of many factors involved in proliferation, vascularization and decidualization of cells. Activity of most of these factors is due to the leptin action, however, there are no studies of the direct effect of leptin in the pathogenesis of disorders of the endometrium in hyperplastic and inflammatory diseases.

Thus, the purpose of this literature review was to describe the putative molecular mechanisms of the effect of leptin on the development of endometrial pathology.

Literature search was carried out from 03/20/2023 to 05/11/2023 using scientific literature databases: NCBI PubMed, Google Scholar (foreign sources), Cyberleninka, Elibrary (domestic sources): references for the period 1995-2023 were analyzed. The following keywords were used for the search: leptin, endometrial dysfunction, endometrial receptivity, inflammation, pelvic inflammatory disease.

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The authors declare that there are no conflicts of interest present.