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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl13400</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-13400</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Репродуктивная эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reproductive Endocrinology</subject></subj-group></article-categories><title-group><article-title>Синдром поликистозных яичников: новые и перспективные варианты лечения</article-title><trans-title-group xml:lang="en"><trans-title>Polycystic ovary syndrome: new and promising treatment methods</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0751-8749</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гасиева</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gasieva</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гасиева Дана Муратовна</p><p>117036, Москва, ул. Дм. Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Dana M. Gasieva - clinical resident.</p><p>11 Dm.Ulyanova street, 117036 Moscow</p></bio><email xlink:type="simple">gasieva99@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7177-0254</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шереметьева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheremetyeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шереметьева Екатерина Викторовна - к.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>Ekaterina V. Sheremetyeva - MD, PhD.</p><p>Moscow</p></bio><email xlink:type="simple">s1981k@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1282-2576</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калашникова</surname><given-names>М. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalashnikova</surname><given-names>M. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Калашникова Марина Федоровна - д.м.н., профессор.</p><p>Москва</p></bio><bio xml:lang="en"><p>Marina F. Kalashnikova - MD, PhD, Professor.</p><p>Moscow</p></bio><email xlink:type="simple">marina_kalash@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7314-9063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзгоева</surname><given-names>Ф. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzgoeva</surname><given-names>F. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дзгоева Фатима Хаджимуратовна - к.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>Fatima Kh. Dzgoeva - MD, Cand. Sci. (Med.)</p><p>Moscow</p></bio><email xlink:type="simple">fatima.dzgoeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-2086-2167</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алборова</surname><given-names>Е. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Alborova</surname><given-names>E. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алборова Елена Тамерлановна</p><p>Москва</p></bio><bio xml:lang="en"><p>Elena T. Alborova - clinical resident.</p><p>Moscow</p></bio><email xlink:type="simple">alborova723@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр эндокринологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт клинической медицины им. Н.В. Склифосовского Первого МГМУ им. И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovskiy Institute of Clinical Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>09</month><year>2024</year></pub-date><volume>70</volume><issue>4</issue><fpage>103</fpage><lpage>113</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гасиева Д.М., Шереметьева Е.В., Калашникова М.Ф., Дзгоева Ф.Х., Алборова Е.Т., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Гасиева Д.М., Шереметьева Е.В., Калашникова М.Ф., Дзгоева Ф.Х., Алборова Е.Т.</copyright-holder><copyright-holder xml:lang="en">Gasieva D.M., Sheremetyeva E.V., Kalashnikova M.F., Dzgoeva F.K., Alborova E.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/13400">https://www.probl-endojournals.ru/jour/article/view/13400</self-uri><abstract><p>Синдром поликистозных яичников (СПЯ) — полигенное эндокринное расстройство, обусловленное как генетическими, гормональными, так и эпигенетическими факторами. Во всем мире актуальность проблемы СПЯ обусловлена распространенностью синдрома от 10 до 13%, а также развитием сопряженных с ним состояний, негативно влияющих на здоровье и жизнь женщины: бесплодие, дерматологические проявления гиперандрогении (гирсутизм, угревая болезнь), сердечно-сосудистые патологии, метаболические и психоэмоциональные нарушения. В настоящее время предложено много теорий развития данного заболевания, и как следствие — методов воздействия на него и лечения. Согласно клиническим рекомендациям Минздрава РФ, в основу комплексной терапии положена модификация образа жизни пациентки. Мы провели анализ около 60 статей, посвященных различным диетологическим подходам к лечению СПЯ. Поиск статей проводился на базе PubMed, Nature reviews, Oxford academic, Clinical nutrition, EJOG, Science Direct, MDPI. Лучше всего себя зарекомендовала средиземноморская диета, DASH-диета, кетогенная диета и низкоуглеводная. Также не стоит игнорировать необходимость добавления в рацион женщины витаминов D и Е, фолиевой кислоты, кальция, различных про- и пребиотиков. Перспективным методом терапии СПЯ в настоящее время становится применение инозитола и препаратов ГПП-1. Согласно результатам проведенного анализа, отмечено значительное влияние диетотерапии на антропометрические и биохимические показатели женщины. Основное, что мы хотим сказать: в подходе к лечению пациенток с СПЯ стоит учитывать индивидуальные особенности каждой и не ограничиваться только медикаментозной терапией.</p></abstract><trans-abstract xml:lang="en"><p>Polycystic Ovary Syndrome (PCOS) — is a polygenic endocrine disorder caused by genetic, hormonal, and epigenetic factors. The importance of addressing PCOS lies in its prevalence, affecting approximately 10 to 13% of women, as well as the associated health conditions that can have a negative impact on women’s lives, including infertility, dermatological manifestations of hyperandrogenism (such as hirsutism and acne), cardiovascular pathologies, metabolic disorders, and psychoemotional disorders. Currently, many theories of the development of this disease have been proposed, and as a consequence of methods of influencing and treating it. According to the clinical recommendations of the Ministry of Health of the Russian Federation, modifying the patient’s lifestyle forms the basis of comprehensive therapy. We have analyzed about 60 articles on various dietary approaches to the treatment of PCOS, sourced from PubMed, Nature Reviews, Oxford Academic, Clinical Nutrition, EJOG, ScienceDirect, and MDPI. The Mediterranean diet, the DASH diet, the ketogenic diet and the low-carb diet have proven themselves the best. Also, it’s necessary to add vitamin D, E, folic acid, calcium, various pro- and prebiotics to a woman’s diet. Currently, the use of inositol and GPP-1 is becoming a promising method of PCOS therapy. According to the results of the analysis, a positive effect of diet therapy on the anthropometric and biochemical parameters was noted. Based on the analysis, a positive effect of diet therapy on anthropometric and biochemical parameters has been observed. It is crucial to consider the individual characteristics of each patient and not rely solely on drug therapy when approaching the treatment of PCOS.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>СПЯ</kwd><kwd>диетотерапия</kwd><kwd>инозитол</kwd><kwd>витамин D</kwd><kwd>витамин Е</kwd></kwd-group><kwd-group xml:lang="en"><kwd>PCOS</kwd><kwd>diet</kwd><kwd>inositol</kwd><kwd>vitamin D</kwd><kwd>vitamin E</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках государственного задания №123021300169-4 «Эпигенетические предикторы и метаболомная составляющая аменореи различного генеза у женщин репродуктивного возраста», 2023–2025 гг.</funding-statement></funding-group></article-meta></front><back><ref-list><ref id="cit1"><mixed-citation publication-type="commun" publication-format="web"><article-title>Sindrom polikistoznykh yaichnikov: Klinicheskie rekomendatsii MZ RF.</article-title> — Moskva, <year>2023</year>; 61 s. 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