problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13423problendo-13423Research ArticleКлиническая эндокринологияClinical endocrinologyЦефалгический синдром у больных акромегалиейCephalgic syndrome in patients with acromegalyhttps://orcid.org/0000-0002-6892-6024НуруллинаГ. М.NurullinaG. N.

Нуруллина Гузель Михайловна - к.м.н.

426039, Ижевск, ул. Воткинское шоссе, д. 57

Guzel M. Nurullina - PhD.

57 Votkinskoe shosse street, 426039 Izhevsk

dalllila@mai.ruhttps://orcid.org/0000-0002-3992-6420ПушкаревИ. Н.PushkarevI. N.

Пушкарев Игорь Николаевич

Ижевск

Igor N. Pushkarev

Izhevsk

i.push99@yandex.ruhttps://orcid.org/0000-0001-9119-2447ПржиялковскаяЕ. Г.PrzhiyalkovskayaE. G.

Пржиялковская Елена Георгиевна

Москва

Elena G. Przhiyalkovskaya - MD, PhD.

Moscow

przhiyalkovskaya.elena@gmail.comПервая республиканская клиническая больницаРоссияThe First Republican Clinical Hospital of Udmurt RepublicRussian FederationИжевская государственная медицинская академияРоссияIzhevsk State Medical AcademyRussian FederationНаучный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2024041120247051422Copyright © Нуруллина Г.М., Пушкарев И.Н., Пржиялковская Е.Г., 20242024Нуруллина Г.М., Пушкарев И.Н., Пржиялковская Е.Г.Nurullina G.N., Pushkarev I.N., Przhiyalkovskaya E.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13423

Целью данного обзора является обобщение имеющихся в литературе данных о причинах головной боли, возникающей у пациентов с акромегалией, а также о влиянии различных методов лечения акромегалии на головную боль. Поиск публикаций производился в базе данных PubMed по ключевым словам: «Headache in patients with acromegaly», «Headache in patients with pituitary adenomas», «Tension-type headache», «Migraine». Головная боль у пациентов с аденомами гипофиза, секретирующими соматотропный гормон (СТГ), — нередкое явление: по данным разных авторов, цефалгический синдром встречается у 30–70% больных акромегалией и может ухудшать качество их жизни наряду с другими факторами, вплоть до инвалидизации. По характеру развития головная боль при акромегалии классифицируется на первичную (мигрень, головная боль напряжения, тригеминальные вегетативные цефалгии, например, SUNCT-синдром и кластерные головные боли), а также может вторично вызываться различными причинами, связанными непосредственно с опухолью. Все это требует дифференциальной диагностики. Факторы, вызывающие головные боли при соматотропиномах, пока недостаточно хорошо изучены и требуют дальнейших исследований. К ним относят масс-эффект опухоли, гормональную гиперсекрецию, патологию височно-нижнечелюстного сустава, задержку в организме натрия и жидкости, психологические факторы и др. Авторами проводилась оценка влияния на головную боль различных методов лечения акромегалии: трансназальной транссфеноидальной аденомэктомии, лучевой терапии и медикаментозной терапии аналогами соматостатина, агонистами дофамина и антагонистом рецепторов гормона роста. Однако даже при достижении нормальных уровней СТГ и инсулиноподобного фактора роста 1 (ИФР-1) цефалгический синдром может сохраняться, поэтому пациенты должны быть об этом предупреждены и направлены к цефалгологу для подбора адекватной терапии головной боли.

The aim of this review is to summarize the data available in the literature on the causes of headache in patients with acromegaly, as well as on the effect of various methods of acromegaly treatment on headache. Publications were searched in the PubMed database using the keywords «Headache in patients with acromegaly», «Headache in patients with pituitary adenomas», «Tension-type headache», «Migraine». Headache in patients with pituitary adenomas secreting somatotropic hormone (STH) is not uncommon: according to various authors, cephalgic syndrome occurs in 30–70% of patients with acromegaly and can worsen their quality of life, along with other factors, up to disability. By the nature of development, headache with acromegaly is classified into primary (migraine, tension headache, trigeminal autonomic cephalgia, for example, SUNCT syndrome and cluster headaches), and can also be caused by various causes directly related to the tumor. All this requires differential diagnosis. The factors causing headaches in somatotropinomas have not yet been well studied and require further research. These include the mass effect of the tumor, hormonal hypersecretion, pathology of the temporomandibular joint, sodium and fluid retention in the body, psychological factors, etc. The authors evaluated the effect on headache of various methods of acromegaly treatment: transnasal transsphenoidal adenomectomy, radiation therapy and drug therapy with somatostatin analogues, dopamine agonists and growth hormone receptor antagonist. However, even when normal levels of STH and insulin-like growth factor 1 (IGF-1) are reached, cephalgic syndrome may persist, therefore patients should be warned about this in advance and referred to a cephalgologist to select adequate headache therapy.

акромегалияаденома гипофизаголовная больacromegalypituitary adenomaheadacheРабота выполнена по инициативе авторов без привлечения финансированияРабота выполнена по инициативе авторов без привлечения финансированияReferencesDonovan LE, Welch MR. Headaches in Patients with Pituitary Tumors: a Clinical Conundrum. Curr Pain Headache Rep. 2018;22(8):57. doi: https://doi.org/10.1007/s11916-018-0709-1Donovan LE, Welch MR. Headaches in Patients with Pituitary Tumors: a Clinical Conundrum. Curr Pain Headache Rep. 2018;22(8):57. doi: https://doi.org/10.1007/s11916-018-0709-1Puledda F, Silva EM, Suwanlaong K, Goadsby PJ. Migraine: from pathophysiology to treatment. J Neurol. 2023;270(7):3654-3666. doi: https://doi.org/10.1007/s00415-023-11706-1Puledda F, Silva EM, Suwanlaong K, Goadsby PJ. Migraine: from pathophysiology to treatment. J Neurol. 2023;270(7):3654-3666. doi: https://doi.org/10.1007/s00415-023-11706-1Yu B, Ji N, Ma Y, Yang B, Kang P, Luo F. Clinical characteristics and risk factors for headache associated with non-functioning pituitary adenomas. Cephalalgia. 2017;37(4):348-355. doi: https://doi.org/10.1177/0333102416648347Yu B, Ji N, Ma Y, Yang B, Kang P, Luo F. Clinical characteristics and risk factors for headache associated with non-functioning pituitary adenomas. Cephalalgia. 2017;37(4):348-355. doi: https://doi.org/10.1177/0333102416648347Lake MG, Krook LS, Cruz SV. Pituitary adenomas: an overview. Am Fam Physician. 2013;88(5):319-327Lake MG, Krook LS, Cruz SV. Pituitary adenomas: an overview. Am Fam Physician. 2013;88(5):319-327Giustina A, Gola M, Colao A, et al. The management of the patient with acromegaly and headache: a still open clinical challenge. J Endocrinol Invest. 2008;31(10):919-924. doi: https://doi.org/10.1007/BF0334644Giustina A, Gola M, Colao A, et al. The management of the patient with acromegaly and headache: a still open clinical challenge. J Endocrinol Invest. 2008;31(10):919-924. doi: https://doi.org/10.1007/BF0334644Нуруллина Г.М., Ахмадуллина Г.И., Маслова И.С., Николаева А.Р. Клинические характеристики и эффективность лечения акромегалии в Удмуртской Республике по данным регионального регистра // Альманах клинической медицины. — 2022. — Т. 50. — №3. — C. 170-176 doi: https://doi.org/10.18786/2072-0505-2022-50-037Nurullina GM, Akhmadullina GI, Maslova IS, Nikolaeva AR. Clinical characteristics and efficacy of acromegaly treatment in the Udmurt Republic. Almanac of Clinical Medicine. 2022;50(3):170-176. (in Russ.) doi: https://doi.org/10.18786/2072-0505-2022-50-037Zhang Y, Pan Q, Jiang H, et al. A prospective study of headache and neuropeptides in patients with pituitary adenomas. Cephalalgia. 2019;39(8):1049-1057. doi: https://doi.org/10.1177/0333102419839963Zhang Y, Pan Q, Jiang H, et al. A prospective study of headache and neuropeptides in patients with pituitary adenomas. Cephalalgia. 2019;39(8):1049-1057. doi: https://doi.org/10.1177/0333102419839963Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ. The clinical characteristics of headache in patients with pituitary tumours. Brain. 2005;128(Pt8):1921-1930. doi: https://doi.org/10.1093/brain/awh525Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ. The clinical characteristics of headache in patients with pituitary tumours. Brain. 2005;128(Pt8):1921-1930. doi: https://doi.org/10.1093/brain/awh525Schankin CJ, Reifferscheid AK, Krumbholz M, et al. Headache in patients with pituitary adenoma: clinical and paraclinical findings. Cephalalgia. 2012;32(16):1198-1207. doi: https://doi.org/10.1177/033310241246263Schankin CJ, Reifferscheid AK, Krumbholz M, et al. Headache in patients with pituitary adenoma: clinical and paraclinical findings. Cephalalgia. 2012;32(16):1198-1207. doi: https://doi.org/10.1177/033310241246263Dallel S, Devoize L, Tauveron I, et al. Characteristics of pain in patients with pituitary adenomas: A cross-sectional study. Eur J Pain. 2021;25(4):913-923. doi: https://doi.org/10.1002/ejp.1721Dallel S, Devoize L, Tauveron I, et al. Characteristics of pain in patients with pituitary adenomas: A cross-sectional study. Eur J Pain. 2021;25(4):913-923. doi: https://doi.org/10.1002/ejp.1721Kreitschmann-Andermahr I, Siegel S, Weber Carneiro R, Maubach JM, Harbeck B, Brabant G. Headache and pituitary disease: a systematic review. Clin Endocrinol (Oxf). 2013;79(6):760-769. doi: https://doi.org/10.1111/cen.12314Kreitschmann-Andermahr I, Siegel S, Weber Carneiro R, Maubach JM, Harbeck B, Brabant G. Headache and pituitary disease: a systematic review. Clin Endocrinol (Oxf). 2013;79(6):760-769. doi: https://doi.org/10.1111/cen.12314Darendeliler F, Karagiannis G, Wilton P. Headache, idiopathic intracranial hypertension and slipped capital femoral epiphysis during growth hormone treatment: a safety update from the KIGS database. Horm Res. 2007;68(Suppl 5):41-47. doi: https://doi.org/10.1159/000110474Darendeliler F, Karagiannis G, Wilton P. Headache, idiopathic intracranial hypertension and slipped capital femoral epiphysis during growth hormone treatment: a safety update from the KIGS database. Horm Res. 2007;68(Suppl 5):41-47. doi: https://doi.org/10.1159/000110474Graff-Radford SB. Temporomandibular disorders and headache. Dent Clin North Am. 2007;51(1):129-vii. doi: https://doi.org/10.1016/j.cden.2006.09.005Graff-Radford SB. Temporomandibular disorders and headache. Dent Clin North Am. 2007;51(1):129-vii. doi: https://doi.org/10.1016/j.cden.2006.09.005Gondim JA, de Almeida JP, de Albuquerque LA, Schops M, Gomes E, Ferraz T. Headache associated with pituitary tumors. J Headache Pain. 2009;10(1):15-20. doi: https://doi.org/10.1007/s10194-008-0084-0Gondim JA, de Almeida JP, de Albuquerque LA, Schops M, Gomes E, Ferraz T. Headache associated with pituitary tumors. J Headache Pain. 2009;10(1):15-20. doi: https://doi.org/10.1007/s10194-008-0084-0Suri H, Dougherty C. Clinical Presentation and Management of Headache in Pituitary Tumors. Curr Pain Headache Rep. 2018;22(8):55. doi: https://doi.org/10.1007/s11916-018-0710-8Suri H, Dougherty C. Clinical Presentation and Management of Headache in Pituitary Tumors. Curr Pain Headache Rep. 2018;22(8):55. doi: https://doi.org/10.1007/s11916-018-0710-8Arafah BM, Prunty D, Ybarra J, Hlavin ML, Selman WR. The dominant role of increased intrasellar pressure in the pathogenesis of hypopituitarism, hyperprolactinemia, and headaches in patients with pituitary adenomas. J Clin Endocrinol Metab. 2000;85(5):1789-1793. doi: https://doi.org/10.1210/jcem.85.5.6611Arafah BM, Prunty D, Ybarra J, Hlavin ML, Selman WR. The dominant role of increased intrasellar pressure in the pathogenesis of hypopituitarism, hyperprolactinemia, and headaches in patients with pituitary adenomas. J Clin Endocrinol Metab. 2000;85(5):1789-1793. doi: https://doi.org/10.1210/jcem.85.5.6611Hayashi Y, Sasagawa Y, Oishi M, et al. Contribution of Intrasellar Pressure Elevation to Headache Manifestation in Pituitary Adenoma Evaluated With Intraoperative Pressure Measurement. Neurosurgery. 2019;84(3):599-606. doi: https://doi.org/10.1093/neuros/nyy087Hayashi Y, Sasagawa Y, Oishi M, et al. Contribution of Intrasellar Pressure Elevation to Headache Manifestation in Pituitary Adenoma Evaluated With Intraoperative Pressure Measurement. Neurosurgery. 2019;84(3):599-606. doi: https://doi.org/10.1093/neuros/nyy087Levy MJ. The association of pituitary tumors and headache. Curr Neurol Neurosci Rep. 2011;11(2):164-170. doi: https://doi.org/10.1007/s11910-010-0166-7Levy MJ. The association of pituitary tumors and headache. Curr Neurol Neurosci Rep. 2011;11(2):164-170. doi: https://doi.org/10.1007/s11910-010-0166-7Kaiser EA, Russo AF. CGRP and migraine: could PACAP play a role too? Neuropeptides. 2013;47(6):451-461. doi: https://doi.org/10.1016/j.npep.2013.10.010Kaiser EA, Russo AF. CGRP and migraine: could PACAP play a role too? Neuropeptides. 2013;47(6):451-461. doi: https://doi.org/10.1016/j.npep.2013.10.010King HJ, Luther E, Morell AA, Ivan M, Komotar RJ. Management of a Growth Hormone-Secreting Pituitary Macroadenoma Associated With Idiopathic Intracranial Hypertension and an Empty Sella. Cureus. 2023;15(1):e34471. doi: https://doi.org/10.7759/cureus.34471King HJ, Luther E, Morell AA, Ivan M, Komotar RJ. Management of a Growth Hormone-Secreting Pituitary Macroadenoma Associated With Idiopathic Intracranial Hypertension and an Empty Sella. Cureus. 2023;15(1):e34471. doi: https://doi.org/10.7759/cureus.34471Olson SL, Wallace JD, Atkinson L, Cuneo RC: Benign intracranial hypertension associated with acromegaly. Endocrinologist. 2005;15:4. doi: https://doi.org/10.1097/01.ten.0000162371.75025.59Olson SL, Wallace JD, Atkinson L, Cuneo RC: Benign intracranial hypertension associated with acromegaly. Endocrinologist. 2005;15:4. doi: https://doi.org/10.1097/01.ten.0000162371.75025.59Malozowski S, Tanner LA, Wysowski DK, Fleming GA, Stadel BV. Benign intracranial hypertension in children with growth hormone deficiency treated with growth hormone. J Pediatr. 1995;126(6):996-999. doi: https://doi.org/10.1016/s0022-3476(95)70232-6Malozowski S, Tanner LA, Wysowski DK, Fleming GA, Stadel BV. Benign intracranial hypertension in children with growth hormone deficiency treated with growth hormone. J Pediatr. 1995;126(6):996-999. doi: https://doi.org/10.1016/s0022-3476(95)70232-6Lampit M, Nave T, Hochberg Z. Water and sodium retention during short-term administration of growth hormone to short normal children. Horm Res. 1998;50(2):83-88. doi: https://doi.org/10.1159/000023239Lampit M, Nave T, Hochberg Z. Water and sodium retention during short-term administration of growth hormone to short normal children. Horm Res. 1998;50(2):83-88. doi: https://doi.org/10.1159/000023239Maione L, Chanson P. National acromegaly registries. Best Pract Res Clin Endocrinol Metab. 2019;33(2):101264. doi: https://doi.org/10.1016/j.beem.2019.02.001Maione L, Chanson P. National acromegaly registries. Best Pract Res Clin Endocrinol Metab. 2019;33(2):101264. doi: https://doi.org/10.1016/j.beem.2019.02.001Puglisi S, Terzolo M. Hypertension and Acromegaly. Endocrinol Metab Clin North Am. 2019;48(4):779-793. doi: https://doi.org/10.1016/j.ecl.2019.08.008Puglisi S, Terzolo M. Hypertension and Acromegaly. Endocrinol Metab Clin North Am. 2019;48(4):779-793. doi: https://doi.org/10.1016/j.ecl.2019.08.008Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. doi: https://doi.org/10.1177/0333102417738202Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. doi: https://doi.org/10.1177/0333102417738202Finocchi C, Sassos D. Headache and arterial hypertension. Neurol Sci. 2017;38(Suppl 1):67-72. doi: https://doi.org/10.1007/s10072-017-2893-xFinocchi C, Sassos D. Headache and arterial hypertension. Neurol Sci. 2017;38(Suppl 1):67-72. doi: https://doi.org/10.1007/s10072-017-2893-xZhang J, Mao Y, Li Y, et al. Association between migraine or severe headache and hypertension among US adults: A cross-sectional study. Nutr Metab Cardiovasc Dis. 2023;33(2):350-358. doi: https://doi.org/10.1016/j.numecd.2022.11.014Zhang J, Mao Y, Li Y, et al. Association between migraine or severe headache and hypertension among US adults: A cross-sectional study. Nutr Metab Cardiovasc Dis. 2023;33(2):350-358. doi: https://doi.org/10.1016/j.numecd.2022.11.014Wechsler S. Facial Pain and Temporomandibular Joint Dysfunction Secondary to Acromegaly: Treatment with Manual Therapy, Neuromuscular Re-education - A Case Report. Rehabil Oncol. 2020;38(3):127-133. doi: https://doi.org/10.1097/01.reo.0000000000000190Wechsler S. Facial Pain and Temporomandibular Joint Dysfunction Secondary to Acromegaly: Treatment with Manual Therapy, Neuromuscular Re-education - A Case Report. Rehabil Oncol. 2020;38(3):127-133. doi: https://doi.org/10.1097/01.reo.0000000000000190Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015;91(6):378-386Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015;91(6):378-386Thomas DC, Khan J, Manfredini D, Ailani J. Temporomandibular Joint Disorder Comorbidities. Dent Clin North Am. 2023;67(2):379-392. doi: https://doi.org/10.1016/j.cden.2022.10.005Thomas DC, Khan J, Manfredini D, Ailani J. Temporomandibular Joint Disorder Comorbidities. Dent Clin North Am. 2023;67(2):379-392. doi: https://doi.org/10.1016/j.cden.2022.10.005Donegan D, Erickson D. Revisiting Pituitary Apoplexy. J Endocr Soc. 2022;6(9):bvac113. doi: https://doi.org/10.1210/jendso/bvac113Donegan D, Erickson D. Revisiting Pituitary Apoplexy. J Endocr Soc. 2022;6(9):bvac113. doi: https://doi.org/10.1210/jendso/bvac113Нуруллина Г.М., Пушкарев И.Н., Пигарова Е.А., Латкина Н.В., Ахмадуллина Г.И. Кровоизлияние в соматотропиному как первый повод для обследования пациентки с ранее не диагностированными акромегалией и папиллярным раком щитовидной железы // Альманах клинической медицины. — 2023. — Т. 51. — №2. — С. 126–133 doi: https://doi.org/10.18786/2072-0505-2023-51-011Nurullina GM, Pushkarev IN, Pigarova EA, Latkina NV, Akhmadullina GI. Hemorrhage into a somatotropinoma аs a first reason for examination of a patient with previously undiagnosed acromegaly and papillary thyroid cancer. Almanac of Clinical Medicine. 2023;51(2):126–133 (In Russ.). doi: https://doi.org/10.18786/2072-0505-2023-51-011Suri H, Dougherty C. Presentation and Management of Headache in Pituitary Apoplexy. Curr Pain Headache Rep. 2019;23(9):61. doi: https://doi.org/10.1007/s11916-019-0798-5Suri H, Dougherty C. Presentation and Management of Headache in Pituitary Apoplexy. Curr Pain Headache Rep. 2019;23(9):61. doi: https://doi.org/10.1007/s11916-019-0798-5Gadelha MR, Kasuki L, Lim DST, Fleseriu M. Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update. Endocr Rev. 2019;40(1):268-332. doi: https://doi.org/10.1210/er.2018-00115Gadelha MR, Kasuki L, Lim DST, Fleseriu M. Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update. Endocr Rev. 2019;40(1):268-332. doi: https://doi.org/10.1210/er.2018-00115Moon S, Hong S, Han K, Park CY. Risk of depression in patients with acromegaly in Korea (2006-2016): a nationwide population-based study. Eur J Endocrinol. 2023;189(3):363-371. doi: https://doi.org/10.1093/ejendo/lvad120Moon S, Hong S, Han K, Park CY. Risk of depression in patients with acromegaly in Korea (2006-2016): a nationwide population-based study. Eur J Endocrinol. 2023;189(3):363-371. doi: https://doi.org/10.1093/ejendo/lvad120Lampl C, Thomas H, Tassorelli C, et al. Headache, depression and anxiety: associations in the Eurolight project. J Headache Pain. 2016;17:59. doi: https://doi.org/10.1186/s10194-016-0649-2Lampl C, Thomas H, Tassorelli C, et al. Headache, depression and anxiety: associations in the Eurolight project. J Headache Pain. 2016;17:59. doi: https://doi.org/10.1186/s10194-016-0649-2Cho SJ, Song TJ, Chu MK. Sleep and Tension-Type Headache. Curr Neurol Neurosci Rep. 2019;19(7):44. doi: https://doi.org/10.1007/s11910-019-0953-8Cho SJ, Song TJ, Chu MK. Sleep and Tension-Type Headache. Curr Neurol Neurosci Rep. 2019;19(7):44. doi: https://doi.org/10.1007/s11910-019-0953-8Andersson A, Hallén T, Olsson DS, et al. Headache Before and After Endoscopic Transsphenoidal Pituitary Tumor Surgery: A Prospective Study. J Neurol Surg B Skull Base. 2021;83(Suppl 2):e360-e366. doi: https://doi.org/10.1055/s-0041-1729180Andersson A, Hallén T, Olsson DS, et al. Headache Before and After Endoscopic Transsphenoidal Pituitary Tumor Surgery: A Prospective Study. J Neurol Surg B Skull Base. 2021;83(Suppl 2):e360-e366. doi: https://doi.org/10.1055/s-0041-1729180Wang SJ, Hung CW, Fuh JL, Lirng JF, Hwu CM. Cranial autonomic symptoms in patients with pituitary adenoma presenting with headaches. Acta Neurol Taiwan. 2009;18(2):104-112Wang SJ, Hung CW, Fuh JL, Lirng JF, Hwu CM. Cranial autonomic symptoms in patients with pituitary adenoma presenting with headaches. Acta Neurol Taiwan. 2009;18(2):104-112Fleseriu M, Biller BMK, Freda PU, et al. A Pituitary Society update to acromegaly management guidelines. Pituitary. 2021;24(1):1-13. doi: https://doi.org/10.1007/s11102-020-01091-7Fleseriu M, Biller BMK, Freda PU, et al. A Pituitary Society update to acromegaly management guidelines. Pituitary. 2021;24(1):1-13. doi: https://doi.org/10.1007/s11102-020-01091-7Rocha Filho PA, Galvão AC, Teixeira MJ, et al. SUNCT syndrome associated with pituitary tumor: case report. Arq Neuropsiquiatr. 2006;64(2B):507-510. doi: https://doi.org/10.1590/s0004-282x2006000300029Rocha Filho PA, Galvão AC, Teixeira MJ, et al. SUNCT syndrome associated with pituitary tumor: case report. Arq Neuropsiquiatr. 2006;64(2B):507-510. doi: https://doi.org/10.1590/s0004-282x2006000300029Kaniuka-Jakubowska S, Levy MJ, Pal A, et al. A study of acromegaly-associated headache with somatostatin analgesia. Endocr Relat Cancer. 2023;30(3):e220138. doi: https://doi.org/10.1530/ERC-22-0138Kaniuka-Jakubowska S, Levy MJ, Pal A, et al. A study of acromegaly-associated headache with somatostatin analgesia. Endocr Relat Cancer. 2023;30(3):e220138. doi: https://doi.org/10.1530/ERC-22-0138Lovato CM, Kapsner PL. Analgesic effect of long-acting somatostatin receptor agonist pasireotide in a patient with acromegaly and intractable headaches. BMJ Case Rep. 2018;2018:bcr2017219686. doi: https://doi.org/10.1136/bcr-2017-219686Lovato CM, Kapsner PL. Analgesic effect of long-acting somatostatin receptor agonist pasireotide in a patient with acromegaly and intractable headaches. BMJ Case Rep. 2018;2018:bcr2017219686. doi: https://doi.org/10.1136/bcr-2017-219686Curtis SB, Hewitt J, Yakubovitz S, Anzarut A, Hsiang YN, Buchan AM. Somatostatin receptor subtype expression and function in human vascular tissue. Am J Physiol Heart Circ Physiol. 2000;278(6):H1815-H1822. doi: https://doi.org/10.1152/ajpheart.2000.278.6.H1815Curtis SB, Hewitt J, Yakubovitz S, Anzarut A, Hsiang YN, Buchan AM. Somatostatin receptor subtype expression and function in human vascular tissue. Am J Physiol Heart Circ Physiol. 2000;278(6):H1815-H1822. doi: https://doi.org/10.1152/ajpheart.2000.278.6.H1815Marina D, Burman P, Klose M, et al. Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues — Observations in two patients with acromegaly and severe headache. Growth Horm IGF Res. 2015;25(5):262-267. doi: https://doi.org/10.1016/j.ghir.2015.07.003Marina D, Burman P, Klose M, et al. Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues — Observations in two patients with acromegaly and severe headache. Growth Horm IGF Res. 2015;25(5):262-267. doi: https://doi.org/10.1016/j.ghir.2015.07.003Matharu MS, Levy MJ, Meeran K, Goadsby PJ. Subcutaneous octreotide in cluster headache: randomized placebo-controlled double-blind crossover study [published correction appears in Ann Neurol. 2004 Nov;56(5):751]. Ann Neurol. 2004;56(4):488-494. doi: https://doi.org/10.1002/ana.20210Matharu MS, Levy MJ, Meeran K, Goadsby PJ. Subcutaneous octreotide in cluster headache: randomized placebo-controlled double-blind crossover study [published correction appears in Ann Neurol. 2004 Nov;56(5):751]. Ann Neurol. 2004;56(4):488-494. doi: https://doi.org/10.1002/ana.20210Otsuka F, Mizobuchi S, Ogura T, Sato K, Yokoyama M, Makino H. Long-term effects of octreotide on pituitary gigantism: its analgesic action on cluster headache. Endocr J. 2004;51(5):449-452. doi: https://doi.org/10.1507/endocrj.51.449Otsuka F, Mizobuchi S, Ogura T, Sato K, Yokoyama M, Makino H. Long-term effects of octreotide on pituitary gigantism: its analgesic action on cluster headache. Endocr J. 2004;51(5):449-452. doi: https://doi.org/10.1507/endocrj.51.449Giustina A, Arnaldi G, Bogazzi F, et al. Pegvisomant in acromegaly: an update [published correction appears in J Endocrinol Invest. 2017 Dec 28]. J Endocrinol Invest. 2017;40(6):577-589. doi: https://doi.org/10.1007/s40618-017-0614-1Giustina A, Arnaldi G, Bogazzi F, et al. Pegvisomant in acromegaly: an update [published correction appears in J Endocrinol Invest. 2017 Dec 28]. J Endocrinol Invest. 2017;40(6):577-589. doi: https://doi.org/10.1007/s40618-017-0614-1Ershadinia N, Tritos NA. Diagnosis and Treatment of Acromegaly: An Update. Mayo Clin Proc. 2022;97(2):333-346. doi: https://doi.org/10.1016/j.mayocp.2021.11.007Ershadinia N, Tritos NA. Diagnosis and Treatment of Acromegaly: An Update. Mayo Clin Proc. 2022;97(2):333-346. doi: https://doi.org/10.1016/j.mayocp.2021.11.007Pulido Fontes L, Mayor Gómez S. SUNCT (Short-lasting unilateral neuralgiform headache attack with conjunctival injection and tearing) associated with pituitary lesion. Neurologia. 2015;30(7):458-459. doi: https://doi.org/10.1016/j.nrl.2013.09.00Pulido Fontes L, Mayor Gómez S. SUNCT (Short-lasting unilateral neuralgiform headache attack with conjunctival injection and tearing) associated with pituitary lesion. Neurologia. 2015;30(7):458-459. doi: https://doi.org/10.1016/j.nrl.2013.09.00De Pue A, Lutin B, Paemeleire K. Chronic cluster headache and the pituitary gland. J Headache Pain. 2016;17:23. doi: https://doi.org/10.1186/s10194-016-0614-0De Pue A, Lutin B, Paemeleire K. Chronic cluster headache and the pituitary gland. J Headache Pain. 2016;17:23. doi: https://doi.org/10.1186/s10194-016-0614-0Инструкция по применению препарата Пэгвисомант. Доступно по: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=b6b29f41-ae8b-4e36-95ae-dfb77bb91dceИнструкция по применению препарата Пэгвисомант. Доступно по: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=b6b29f41-ae8b-4e36-95ae-dfb77bb91dceLosa M, Gioia L, Picozzi P, et al. The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. J Clin Endocrinol Metab. 2008;93(7):2546-2552. doi: https://doi.org/10.1210/jc.2008-0135Losa M, Gioia L, Picozzi P, et al. The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. J Clin Endocrinol Metab. 2008;93(7):2546-2552. doi: https://doi.org/10.1210/jc.2008-0135Всероссийское общество неврологов, межрегиональная общественная организация «Российское общество по изучению головной боли». Клинические рекомендации по головной боли напряжения у взрослых, 2021.Vserossijskoe obshchestvo nevrologov, mezhregionalnaya obshchestvennaya organizaciya «Rossijskoe obshchestvo po izucheniyu golovnoj boli». Klinicheskie rekomendacii po golovnoj boli napryazheniya u vzroslyh, 2021 (In Russ.)Всероссийское общество неврологов, межрегиональная общественная организация «Российское общество по изучению головной боли». Клинические рекомендации по мигрени у взрослых, 2021.Vserossijskoe obshchestvo nevrologov, mezhregional’naya obshchestvennaya organizaciya «Rossijskoe obshchestvo po izucheniyu golovnoj boli». Klinicheskie rekomendacii po migreni u vzroslyh, 2021(In Russ.).Zobdeh F, Ben Kraiem A, Attwood MM, et al. Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments. Br J Pharmacol. 2021;178(23):4588-4607. doi: https://doi.org/10.1111/bph.15657Zobdeh F, Ben Kraiem A, Attwood MM, et al. Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments. Br J Pharmacol. 2021;178(23):4588-4607. doi: https://doi.org/10.1111/bph.15657American Headache Society. The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice [published correction appears in Headache. 2019;59(4):650-651]. Headache. 2019;59(1):1-18. doi: https://doi.org/10.1111/head.13456American Headache Society. The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice [published correction appears in Headache. 2019;59(4):650-651]. Headache. 2019;59(1):1-18. doi: https://doi.org/10.1111/head.13456Sacco S, Amin FM, Ashina M, et al. European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention - 2022 update. J Headache Pain. 2022;23(1):67. doi: https://doi.org/10.1186/s10194-022-01431-xSacco S, Amin FM, Ashina M, et al. European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention - 2022 update. J Headache Pain. 2022;23(1):67. doi: https://doi.org/10.1186/s10194-022-01431-xDiener HC, May A. Drug Treatment of Cluster Headache. Drugs. 2022;82(1):33-42. doi: https://doi.org/10.1007/s40265-021-01658-zDiener HC, May A. Drug Treatment of Cluster Headache. Drugs. 2022;82(1):33-42. doi: https://doi.org/10.1007/s40265-021-01658-zCheema S, Matharu M. Cluster Headache: What’s New? Neurol India. 2021;69(Supplement):S124-S134. doi: https://doi.org/10.4103/0028-3886.315983Cheema S, Matharu M. Cluster Headache: What’s New? Neurol India. 2021;69(Supplement):S124-S134. doi: https://doi.org/10.4103/0028-3886.315983Quist TS, Wall M. Growth hormone-related intracranial hypertension. EyeRounds.org. 2019. Available from: http://EyeRounds.org/cases/288-gh-related-iih.htmQuist TS, Wall M. Growth hormone-related intracranial hypertension. EyeRounds.org. 2019. Available from: http://EyeRounds.org/cases/288-gh-related-iih.htmGoyal A, Zarroli K. Should topiramate be initial therapy in the management of idiopathic intracranial hypertension?: A literature review. Medicine (Baltimore). 2023;102(42):e35545. doi: https://doi.org/10.1097/MD.0000000000035545Goyal A, Zarroli K. Should topiramate be initial therapy in the management of idiopathic intracranial hypertension?: A literature review. Medicine (Baltimore). 2023;102(42):e35545. doi: https://doi.org/10.1097/MD.0000000000035545

The authors declare that there are no conflicts of interest present.