problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13456problendo-13456Research ArticleРепродуктивная эндокринологияReproductive EndocrinologyОсобенности иммунологического статуса пациенток с аменореей (обзор литературы)Immunological status in patients with amenorrhea (literature review)https://orcid.org/0000-0003-0696-5367АбсатароваЮ. С.AbsatarovaY. S.

Абсатарова Юлия Сергеевна, к.м.н.

Москва

Yulia S. Absatarova, MD, PhD

Moscow

korsil2008@yandex.ruhttps://orcid.org/0009-0007-8189-1384ЕвсееваЮ. С.EvseevaY. S.

Евсеева Юлия Сергеевна

117036, Москва, ул. Дм. Ульянова, д. 11

Yulia S. Evseeva

11 Dm. Ulyanova street, 117036 Moscow

evseeva.julia09@yandex.ruhttps://orcid.org/0000-0001-8425-0020АндрееваЕ. Н.AndreevaE. N.

Андреева Елена Николаевна, д.м.н., профессор

Москва

Elena N. Andreeva, MD, PhD, professor

Moscow

endogin@mail.ruhttps://orcid.org/0000-0001-6953-6928ЗураеваЗ. Т.ZuraevaZ. T.

Зураева Замира Тотразовна, к.м.н.

Москва

Zamira T. Zuraeva, MD

Moscow

zuraeva_zamira@mail.ruhttps://orcid.org/0000-0001-7177-0254ШереметьеваЕ. В.SheremetyevaE. V.

Шереметьева Екатерина Викторовна, к.м.н.

Москва

Ekaterina V. Sheremetyeva, MD, PhD

Moscow

s1981k@yandex.ruhttps://orcid.org/0000-0003-4979-7420ГригорянО. Р.GrigoryanO. R.

Григорян Ольга Рафаэльевна, д.м.н., профессорМосква

Olga R. Grigoryan, MD, PhD, professor

Moscow

iceberg1995@mail.ruhttps://orcid.org/0000-0001-5826-3186МихеевР. К.MikheevR. K.

Михеев Роберт Константинович

Москва

Robert K. Mikheev, MD, resident

Moscow

iceberg1995@mail.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research Centre RussiaRussian FederationНациональный медицинский исследовательский центр эндокринологии; Российский университет медициныРоссияEndocrinology Research Centre Russia; Russian university of medicineRussian Federation202404062024706118126Copyright © Абсатарова Ю.С., Евсеева Ю.С., Андреева Е.Н., Зураева З.Т., Шереметьева Е.В., Григорян О.Р., Михеев Р.К., 20252025Абсатарова Ю.С., Евсеева Ю.С., Андреева Е.Н., Зураева З.Т., Шереметьева Е.В., Григорян О.Р., Михеев Р.К.Absatarova Y.S., Evseeva Y.S., Andreeva E.N., Zuraeva Z.T., Sheremetyeva E.V., Grigoryan O.R., Mikheev R.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13456

Аменорея — распространенный симптом целого спектра нозологий среди женщин репродуктивного возраста, который может сопровождать любую эндокринопатию в стадии декомпенсации. Во всем многообразии различных звеньев патогенеза нарушений репродуктивной функции проблема иммунопатологии остается немного в стороне, однако значимость этих расстройств недооценена. Настоящая публикация представляет собой обзор нарушений в иммунной системе у женщин с аменореей.Как известно, при синдроме поликистозных яичников (СПЯ) и преждевременной недостаточности яичников (ПНЯ) одним из клинических проявлений является аменорея. С одной стороны, эти нозологии существенно отличаются друг от друга по этиологии, патогенезу и подходам к терапии, а с другой — у них есть сходство, проявляющееся иммунологическими нарушениями. В статье приведены сведения об иммунном статусе пациенток с СПЯ и ПНЯ. Проанализированы работы, посвященные различным расстройствам в иммунной системе, патологиям гуморального и клеточного иммунитета, которые в перспективе могут послужить ключом к разработке новейших и нестандартных методов лечения таких социально значимых заболеваний.Поиск литературы проводили в отечественных (eLibrary, CyberLeninka.ru) и международных (PubMed, Cochrane Library) базах данных на русском и английском языках. Выбор источников был приоритетен периодом с 2018-го по 2024 гг.

Amenorrhea is a common symptom of a whole range of nosologies among women of reproductive age, which can accompany any endocrinopathy in the stage of decompensation. In all the diversity of various links in the pathogenesis of reproductive disorders, the problem of immunopathology remains a little aside, however, the significance of these disorders is underestimated. This publication provides an overview of immune system abnormalities in a women with amenorrhea. As is known, in polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI), one of the clinical manifestations is amenorrhea. On the one hand, these nosologies differ significantly from each other in etiology, pathogenesis and approaches to therapy, and on the other hand, they have a common similarity, manifested by immunological disorders. The article provides information about the immune status of patients with PCOS and POI. Works devoted to various disorders in the immune system, pathologies of humoral and cellular immunity, which in the future may serve as the key to the development of new and non-standard methods of treating such socially significant diseases, are analyzed. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The choice of sources was prioritized for the period from 2018 to 2024.

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The authors declare that there are no conflicts of interest present.