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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl13459</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-13459</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Нарушения углеводного обмена</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Carbohidrates metabolism disturbancies</subject></subj-group></article-categories><title-group><article-title>Predicting Anxiety in Individuals with Diabetes: A Comparative Analysis of Machine Learning Algorithms</article-title><trans-title-group xml:lang="en"><trans-title>Predicting Anxiety in Individuals with Diabetes: A Comparative Analysis of Machine Learning Algorithms</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5772-5534</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bourkhime</surname><given-names>H.</given-names></name><name name-style="western" xml:lang="en"><surname>Bourkhime</surname><given-names>H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Hind Bourkhime, Medical Informatics Specialist, Medical Informatics and Data science Unit, Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez;  Diagnostic center; Medical and Pharmaceutical Sciences and Translational Research, Laboratory of Epidemiology and Health Sciences Research, Faculty of Medicine and Pharmacy of Fez</p><p>B.P. 1893, Km 2.200 Route de Sidi Harazem, Fès 30070,</p></bio><bio xml:lang="en"><p>Hind Bourkhime, Medical Informatics Specialist</p><p>B.P. 1893, Km 2.200 Route de Sidi Harazem, Fès 30070</p></bio><email xlink:type="simple">hbourkhime@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1786-5049</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Qarmiche</surname><given-names>N.</given-names></name><name name-style="western" xml:lang="en"><surname>Qarmiche</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Noura Qarmiche, Associate Professor in Bioinformatics, Laboratory of Artificial Intelligence, Data Science and Emerging Systems, National School of Applied Sciences Fez; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez</p><p>Fez</p></bio><bio xml:lang="en"><p>Noura Qarmiche, Associate Professor in Bioinformatics</p><p>Fez</p></bio><email xlink:type="simple">noura.qarmiche@usmba.ac.ma</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1011-504X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Benmaama</surname><given-names>S.</given-names></name><name name-style="western" xml:lang="en"><surname>Benmaamar</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Soumaya Benmaamar, Associate Professor in Epidemiology, Diagnostic center; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez</p><p>Fez</p></bio><bio xml:lang="en"><p>Soumaya Benmaamar, Associate Professor in Epidemiology</p><p>Fez</p></bio><email xlink:type="simple">soumaya.benmaamar@usmba.ac.ma</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Lazar</surname><given-names>N.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazar</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Nada Lazar, Endocrinology Specialist, Diagnostic center; Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition</p><p>Fez</p></bio><bio xml:lang="en"><p>Nada Lazar, Endocrinology Specialist</p><p>Fez</p></bio><email xlink:type="simple">nada.lazar@usmba.ac.ma</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Omari</surname><given-names>M.</given-names></name><name name-style="western" xml:lang="en"><surname>Omari</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Mohammed Omari, Medical Informatics Specialist, Medical Informatics and Data science Unit, Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez; Diagnostic center</p><p>Fez</p></bio><bio xml:lang="en"><p>Mohammed Omari, Medical Informatics Specialist</p><p>Fez</p></bio><email xlink:type="simple">mohammed.omari@usmba.ac.ma</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Berraho</surname><given-names>M.</given-names></name><name name-style="western" xml:lang="en"><surname>Berraho</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Mohamed Berraho, Full Professor of Epidemiology, Diagnostic center; Medical and Pharmaceutical Sciences and Translational Research, Laboratory of Epidemiology and Health Sciences Research, Faculty of Medicine and Pharmacy of Fez; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez</p><p>Fez</p></bio><bio xml:lang="en"><p>Mohamed Berraho, Full Professor of Epidemiology</p><p>Fez</p></bio><email xlink:type="simple">maberraho@gmail.com</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Tachfouti</surname><given-names>N.</given-names></name><name name-style="western" xml:lang="en"><surname>Tachfouti</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Mohamed Berraho, Full Professor of Epidemiology, Diagnostic center; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez</p><p>Fez</p></bio><bio xml:lang="en"><p>Nabil Tachfouti, Full Professor of Epidemiology</p><p>Fez</p></bio><email xlink:type="simple">nabil.tachfouti@usmba.ac.ma</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>EL Fakir</surname><given-names>S</given-names></name><name name-style="western" xml:lang="en"><surname>EL Fakir</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Samira EL Fakir, Full Professor of Epidemiology, Diagnostic center; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez</p><p>Fez</p></bio><bio xml:lang="en"><p>Samira EL Fakir, Full Professor of Epidemiology</p><p>Fez</p></bio><email xlink:type="simple">samira.elfakir@usmba.ac.ma</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>El Ouahabi</surname><given-names>H.</given-names></name><name name-style="western" xml:lang="en"><surname>El Ouahabi</surname><given-names>H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Samira EL Fakir, Full Professor of Epidemiology, Diagnostic center; Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition</p><p>Fez</p></bio><bio xml:lang="en"><p>Hanan El Ouahabi, Full Professor of Endocrinology</p><p>Fez</p></bio><email xlink:type="simple">hanan.elouahabi@usmba.ac.ma</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Otmani</surname><given-names>N.</given-names></name><name name-style="western" xml:lang="en"><surname>Otmani</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Nada Otmani, Full Professor of Medical Informatics, Medical Informatics and Data science Unit, Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez; Diagnostic center</p><p>Fez</p></bio><bio xml:lang="en"><p>Nada Otmani, Full Professor of Medical Informatics</p><p>Fez</p></bio><email xlink:type="simple">nada.otmani@usmba.ac.ma</email><xref ref-type="aff" rid="aff-7"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Sidi Mohamed Ben Abdellah University; Hassan II University Hospital; Sidi Mohamed Ben Abdellah University</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Medical Informatics and Data science Unit, Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University; Diagnostic center, Hassan II University Hospital; Medical and Pharmaceutical Sciences and Translational Research, Laboratory of Epidemiology and Health Sciences&#13;
Research, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University</institution><country>Morocco</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Sidi Mohamed Ben Abdellah University;  Sidi Mohamed Ben Abdellah University</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Laboratory of Artificial Intelligence, Data Science and Emerging Systems, National School of Applied Sciences Fez, Sidi Mohamed Ben Abdellah University; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University</institution><country>Morocco</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Hassan II University Hospital; Sidi Mohamed Ben Abdellah University</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Diagnostic center, Hassan II University Hospital; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University</institution><country>Morocco</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Hassan II University Hospital</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Diagnostic center, Hassan II University Hospital; Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital</institution><country>Morocco</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Sidi Mohamed Ben Abdellah University; Hassan II University Hospital</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Medical Informatics and Data science Unit, Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University; Diagnostic center, Hassan II University HospitalDiagnostic center, Hassan II University Hospital</institution><country>Morocco</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Hassan II University Hospital; Sidi Mohamed Ben Abdellah University</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Diagnostic center, Hassan II University Hospital; Medical and Pharmaceutical Sciences and Translational Research, Laboratory of Epidemiology and Health Sciences Research, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University; Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University</institution><country>Morocco</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>Sidi Mohamed Ben Abdellah University; Hassan II University Hospital</institution><country>Марокко</country></aff><aff xml:lang="en"><institution>Medical Informatics and Data science Unit, Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University;  Diagnostic center, Hassan II University Hospital</institution><country>Morocco</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>20</day><month>05</month><year>2026</year></pub-date><volume>72</volume><issue>2</issue><fpage>54</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bourkhime H., Qarmiche N., Benmaama S., Lazar N., Omari M., Berraho M., Tachfouti N., EL Fakir S., El Ouahabi H., Otmani N., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Bourkhime H., Qarmiche N., Benmaama S., Lazar N., Omari M., Berraho M., Tachfouti N., EL Fakir S., El Ouahabi H., Otmani N.</copyright-holder><copyright-holder xml:lang="en">Bourkhime H., Qarmiche N., Benmaamar S., Lazar N., Omari M., Berraho M., Tachfouti N., EL Fakir S., El Ouahabi H., Otmani N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/13459">https://www.probl-endojournals.ru/jour/article/view/13459</self-uri><abstract><p>Diabetes is a long-term costly burden that increases the vulnerability of individuals to develop anxiety disorders. Consequently, effective management of diabetes anxiety in diabetics can significantly improve overall patient care.</p><p>This paper presents a comparative analysis of three machine learning algorithms, namely Logistic Regression (LR), Support Vector Machine (SVM), and Decision Tree (DT), in predicting anxiety among diabetics. A Moroccan dataset was utilized, and a grid search approach was employed for hyperparameters tuning.</p><p>The findings demonstrate promising results in terms of the algorithms’ performance. The Decision Tree algorithm exhibited the highest accuracy, achieving an impressive 96% in predicting anxiety among diabetics. SVM followed with an accuracy rate of 69%, while LR achieved 61%. These outcomes provide valuable insights for further research endeavors aimed at refining the prediction models.</p><p>In conclusion, the study highlights the potential of machine learning algorithms in predicting anxiety disorders among individuals with diabetes. The high accuracy demonstrated by the Decision Tree model suggests its potential as a reliable tool in clinical settings. Further investigations are warranted to validate these results and explore the applicability of these models in real-world scenarios, ultimately enhancing the management and well-being of individuals with diabetes and comorbid anxiety disorders.</p></abstract><trans-abstract xml:lang="en"><p>Diabetes is a long-term costly burden that increases the vulnerability of individuals to develop anxiety disorders. Consequently, effective management of diabetes anxiety in diabetics can significantly improve overall patient care. This paper presents a comparative analysis of three machine learning algorithms, namely Logistic Regression (LR), Support Vector Machine (SVM), and Decision Tree (DT), in predicting anxiety among diabetics. A Moroccan dataset was utilized, and a grid search approach was employed for hyperparameters tuning.</p><p>The findings demonstrate promising results in terms of the algorithms’ performance. The Decision Tree algorithm exhibited the highest accuracy, achieving an impressive 96% in predicting anxiety among diabetics. SVM followed with an accuracy rate of 69%, while LR achieved 61%. These outcomes provide valuable insights for further research endeavors aimed at refining the prediction models.</p><p>In conclusion, the study highlights the potential of machine learning algorithms in predicting anxiety disorders among individuals with diabetes. The high accuracy demonstrated by the Decision Tree model suggests its potential as a reliable tool in clinical settings. Further investigations are warranted to validate these results and explore the applicability of these models in real-world scenarios, ultimately enhancing the management and well-being of individuals with diabetes and comorbid anxiety disorders.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Diabetes</kwd><kwd>Anxiety</kwd><kwd>Machine Learning</kwd><kwd>prediction</kwd><kwd>risk</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Diabetes</kwd><kwd>Anxiety</kwd><kwd>Machine Learning</kwd><kwd>prediction</kwd><kwd>risk</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">No funding.</funding-statement><funding-statement xml:lang="en">No funding.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R, IDF Diabetes Atlas Committee. 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