problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13482problendo-13482Research ArticleКлиническая эндокринологияClinical endocrinologyТранскортин: его свойства и функциональная роль в организме человекаThe functional role and properties of transcortin in the human bodyhttps://orcid.org/0000-0001-5592-4794ШевэА.ChevaisA.

Шевэ Анастасия, к.м.н.

117036, Москва, ул. Дм. Ульянова, д. 11

Anastassia Chevais, MD

11 Dm. Ulyanova street, 117036, Moscow

anastassia93@gmail.comhttps://orcid.org/0009-0000-0918-0544ГаджимурадоваМ. М.GadzhimuradovaM. M.

Гаджимурадова Мансурат Мурадовна, аспирант

Москва

Mansurat M. Gadzhimuradova, MD

Moscow

mansurat@mail.ruhttps://orcid.org/0000-0001-7098-4584БельцевичД. Г.BeltsevichD. G.

Бельцевич Дмитрий Германович, д.м.н., профессор

Москва

Dmitry G. Beltsevich, MD, PhD

Moscow

belts67@gmail.comhttps://orcid.org/0000-0003-4994-2456РомановаА. Н.RomanovaA. N.

Романова Алина Николаевна

Москва

Alina N. Romanova, MD

Moscow

himmel98@mail.ruhttps://orcid.org/0009-0003-5232-6440БеговаК. Ш.BegovaK. Sh.

Бегова Камила Шамильевна

Москва

Kamila Sh. Begova

Moscow

kamila_super9@mail.ruhttps://orcid.org/0009-0002-0383-5583БагироваХ. В.BagirovaH. V.

Багирова Ханум Вугаровна

Москва

Hanum V. Bagirova

Moscow

hb1998@mail.ruhttps://orcid.org/0000-0002-3951-4338ЭбзееваА. К.EbzeevaA. K.

Эбзеева Аминат Канаматовна

Москва

Aminat K. Ebzeeva, MD

Moscow

ebzeeva3007@gmail.comhttps://orcid.org/0000-0002-5634-7877МельниченкоГ. А.MelnichenkoG. A.

Мельниченко Галина Афанасьевна, д.м.н., профессор, академик РАН

Москва

Galina A. Melnichenko, MD, PhD, Prof, acad.

Moscow

teofrast2000@mail.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2024010820247062734Copyright © Шевэ А., Гаджимурадова М.М., Бельцевич Д.Г., Романова А.Н., Бегова К.Ш., Багирова Х.В., Эбзеева А.К., Мельниченко Г.А., 20252025Шевэ А., Гаджимурадова М.М., Бельцевич Д.Г., Романова А.Н., Бегова К.Ш., Багирова Х.В., Эбзеева А.К., Мельниченко Г.А.Chevais A., Gadzhimuradova M.M., Beltsevich D.G., Romanova A.N., Begova K.S., Bagirova H.V., Ebzeeva A.K., Melnichenko G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13482

Стероидные гормоны принимают активное участие в целом комплексе физиологических процессов, которые являются основополагающими для нормального развития и функционирования организма. В кровяном русле основная масса стероидных гормонов находится в связанном со специфическими транспортными белками состоянии, в частности с транскортином. Вопросы глюкокортикоидно-белкового комплексообразования при различных состояниях активно изучались во второй половине ХХ века, однако в настоящее время данная проблематика оттеснена на второй план разработкой более точных диагностических методов определения стероидных гормонов. Настоящий обзор литературы представляет накопленные данные о физико-химических свойствах транскортина, генетических факторах, влияющих на его синтез и секрецию. Детально проанализированы опубликованные данные о его физиологическом значении в организме человека в рамках не только гипотезы «свободных гормонов», но и недавно выдвинутой резервуарной гипотезы. Результаты исследований показали, что синтез транскортина был обнаружен в некоторых внепеченочных тканях, в том числе в надпочечниках, однако его роль неизвестна.

Steroid hormones take an active part in a whole complex of physiological processes that are fundamental for the normal development and functioning of the human body. In the bloodstream steroid hormones are bind with specific transport proteins, in particular with transcortin. The matter of changes in hormone-protein complex in various conditions were actively studied in the second half of the twentieth century, but currently this issue has been taken a back seat by the development of high-precision diagnostic methods of steroid hormones determining. This literature review presents accumulated data on the physicochemical properties of transcortin, genetic factors affecting its synthesis and secretion. Published data on its physiological significance in the human body are analyzed in detail within the framework of not only the “free hormone” hypothesis, but also the reservoir hypothesis. Research results have shown that the synthesis of transcortin has been detected in some extrahepatic tissues, including the adrenal glands, however, its role is unknown.

транскортингормонысвязывающие белкиглюкокортикостероидыбуферная системафизиологические механизмы человекаtranscortinhormonesbinding proteinglucocorticosteroidbuffer systemhuman physiological mechanismsРабота выполнена в рамках государственного задания «Разработка новых технологий диагностики и мониторинга опухолей коры надпочечников с использованием метаболомных и протеомных технологий». Регистрационный номер 123021300098-7.ReferencesBae YJ, Kratzsch J. Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications. Best Pract Res Clin Endocrinol Metab. 2015;29(5):761-772. doi: https://doi.org/10.1016/j.beem.2015.09.001Bae YJ, Kratzsch J. Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications. Best Pract Res Clin Endocrinol Metab. 2015;29(5):761-772. doi: https://doi.org/10.1016/j.beem.2015.09.001Daughaday WH. Binding of corticosteroids by plasma proteins. I. 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The authors declare that there are no conflicts of interest present.