problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13483problendo-13483Research ArticleКлиническая эндокринологияClinical endocrinologyФакторы и состояния, влияющие на секрецию и функцию транскортина плазмы кровиFactors and conditions affecting transcortin production and function in blood plasmahttps://orcid.org/0000-0001-5592-4794ШевэА.ChevaisA.

Шевэ Анастасия к.м.н. 

Москва

Anastassia Chevais, MD

Moscow

anastassia93@gmail.comhttps://orcid.org/0000-0001-7098-4584БельцевичД. Г.BeltsevichD. G.

Бельцевич Дмитрий Германович, д.м.н., профессор

Москва

Dmitry G. Beltsevich, MD, PhD

Moscow

belts67@gmail.comhttps://orcid.org/0009-0003-5232-6440ГаджиеваК. Ш.GadzhievaK. Sh.

Гаджиева Камила Шамильевна, ординатор

117036, Москва, ул. Дм. Ульянова, д. 11

Kamila Sh. Gadzhieva

11 Dm. Ulyanova street, 117036, Moscow

kamila_super9@mail.ruhttps://orcid.org/0009-0002-0383-5583БагироваХ. В.BagirovaH. V.

Багирова Ханум Вугаровна

Москва

Hanum V. Bagirova

Moscow

hb1998@mail.ruhttps://orcid.org/0000-0002-3951-4338ЭбзееваА. К.EbzeevaA. K.

Эбзеева Аминат Канаматовна 

Москва

Aminat K. Ebzeeva, MD

Moscow

ebzeeva3007@gmail.comhttps://orcid.org/0000-0003-4994-2456РомановаА. Н.RomanovaA. N.

Романова Алина Николаевна 

Москва

Alina N. Romanova, MD

Moscow

himmel98@mail.ruhttps://orcid.org/0009-0000-0918-0544ГаджимурадоваМ. М.GadzhimuradovaM. M.

Гаджимурадова Мансурат Мурадовна, аспирант

Москва

Mansurat M. Gadzhimuradova, MD

Moscow

mansurat@mail.ruhttps://orcid.org/0000-0002-5634-7877МельниченкоГ. А.MelnichenkoG. A.

Мельниченко Галина Афанасьевна, д.м.н., профессор, академик РАН

Москва

Galina A. Melnichenko, MD, PhD, Prof, acad

Moscow

teofrast2000@mail.ruНациональный медицинский исследовательский центр эндокринологии им. академика И.И. ДедоваРоссияI.I. Dedov Endocrinology Research CentreRussian Federation2025220720257131424Copyright © Шевэ А., Бельцевич Д.Г., Гаджиева К.Ш., Багирова Х.В., Эбзеева А.К., Романова А.Н., Гаджимурадова М.М., Мельниченко Г.А., 20252025Шевэ А., Бельцевич Д.Г., Гаджиева К.Ш., Багирова Х.В., Эбзеева А.К., Романова А.Н., Гаджимурадова М.М., Мельниченко Г.А.Chevais A., Beltsevich D.G., Gadzhieva K.S., Bagirova H.V., Ebzeeva A.K., Romanova A.N., Gadzhimuradova M.M., Melnichenko G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13483

Известно, что основная масса стероидных гормонов в крови находится в связанном с белками-переносчиками состоянии. Транскортин (кортикостероид-связывающий глобулин, SERPINA6), являясь основным транспортным белком стероидных гормонов, образуется главным образом в печени и регулирует системную биодоступность глюкокортикоидов и минералокортикоидов. В настоящей обзорной статье представлены данные литературы о влиянии различных факторов и состояний на ТК (синтез, секрецию и аффинность) и его роли в физиологических и патофизиологических процессах в организме. Снижение уровня ТК происходит в пожилом возрасте, при ожирении и метаболическом синдроме, на фоне таких заболеваний, как цирроз печени, сепсис, политравмы и обширные ожоги, а также при хирургических вмешательствах. Различные препараты могут оказывать влияние на концентрацию ТК в крови, так терапия эстрогенами (например, комбинированные оральные контрацептивы), вызывает значимое повышение ТК в крови, а назначение глюкокортикоидов, в свою очередь, приводит к снижению уровня ТК. Проведен в том числе анализ работ, направленных на изучение влияния ТК и изменение его уровня в крови при эндогенном гиперкортицизме.

It is well-established that the majority of steroid hormones in the bloodstream are in a bound state, complexed with carrier proteins. Transcortin (corticosteroid-binding globulin, SERPINA6) serves as the principal transport protein for steroid hormones and is predominantly synthesized in the liver. Its primary function is to regulate the systemic bioavailability of glucocorticoids and mineralocorticoids. This review article presents an analysis of the existing literature on the impact of various factors and conditions on Transcortin, encompassing its synthesis, secretion, and affinity, as well as its role in physiological and pathophysiological processes within the human body. A reduction in Transcortin levels has been observed in several contexts, including old age, obesity, and metabolic syndrome. Additionally, this decrease is evident in the presence of cirrhosis, sepsis, polytrauma, extensive burns, and during surgical interventions. The concentration of Transcortin in the bloodstream can be influenced by a variety of medications. For instance, estrogen therapy, such as combined oral contraceptives, has been shown to induce a significant increase in Transcortin levels. Conversely, the administration of glucocorticoids has been associated with a decrease in Transcortin levels. Furthermore, this review article includes an analysis of studies that have investigated the influence of Transcortin and alterations in its blood levels in the context of endogenous hypercortisolism. These studies contribute to a deeper understanding of the complex interplay between Transcortin and steroid hormone regulation in various physiological and pathological conditions.

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The authors declare that there are no conflicts of interest present.