problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl13631problendo-13631Research ArticleКлиническая эндокринологияClinical endocrinologyИнвазивный рост аденом гипофиза: значение матриксных металлопротеиназMatrix metalloproteinases in pituitary adenoma invasivenesshttps://orcid.org/0000-0001-6838-9487КутаковаД. В.KutakovaD. V.

Кутакова Дарья Вячеславовна,

117036, Москва, ул. Дм. Ульянова, д. 11

 

Daria V. Kutakova - MD,

11 Dm.Ulyanova street, 117036 Moscow

some91@mail.ruhttps://orcid.org/0000-0002-9314-7831ЛуценкоА. С.LutsenkoA. S.

Луценко Александр Сергеевич, к.м.н.,

117036, Москва, ул. Дм. Ульянова, д. 11

Alexander S. Lutsenko - MD, PhD,

11 Dm.Ulyanova street, 117036 Moscow

sazonova_dv@mail.ruhttps://orcid.org/0000-0001-9119-2447ПржиялковскаяЕ. Г.PrzhiyalkovskayaE. G.

Пржиялковская Елена Георгиевна - к.м.н,

117036, Москва, ул. Дм. Ульянова, д. 11

Elena G. Przhiyalkovskaya - MD, PhD,

11 Dm.Ulyanova street, 117036 Moscow

przhiyalkovskaya.elena@gmail.comhttps://orcid.org/0000-0001-9718-6099АзизянВ. Н.AzizyanV. N.

Азизян Вилен Неронович - к.м.н.,

117036, Москва, ул. Дм. Ульянова, д. 11

Vilen N. Azizyan - PhD, MD, neurosurgeon,

11 Dm.Ulyanova street, 117036 Moscow

vazizyan@mail.ruНациональный медицинский исследовательский центр эндокринологии им. И.И. ДедоваРоссияEndocrinology Research CentreRussian Federation2026070320267215668Copyright © Кутакова Д.В., Луценко А.С., Пржиялковская Е.Г., Азизян В.Н., 20262026Кутакова Д.В., Луценко А.С., Пржиялковская Е.Г., Азизян В.Н.Kutakova D.V., Lutsenko A.S., Przhiyalkovskaya E.G., Azizyan V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/13631

Аденомы гипофиза (АГ) являются наиболее часто встречаемыми опухолями гипоталамо-гипофизарной области. Клиническая картина АГ зависит как от гормональной активности, так и от особенностей распространения опухоли. Несмотря на то, что аденомы гипофиза в подавляющем большинстве случаев являются доброкачественными, они могут расти инвазивно и механически воздействовать на прилежащие структуры. При инвазивном росте аденом гипофиза радикальное удаление затруднительно и сопряжено с более высоким риском операционных осложнений. Патогенез инвазивности аденом гипофиза полностью не изучен. Инвазия опухолевых клеток зависит как от межклеточных взаимодействий внутри аденомы, так и от связи с компонентами внеклеточного матрикса (ВКМ). К факторам, играющим важную роль в данных процессах, относятся ферменты из семейства матриксных металлопротеиназ (ММП) и тканевые ингибиторы матриксных металлопротеиназ (ТИМП). Наибольшее внимание в отношении инвазивности аденом гипофиза уделяется двум представителям ММП — 2 и 9 типов. Интерес к данным молекулам обусловлен их участием в деградации коллагена IV типа, являющегося ключевым компонентом ВКМ гипоталамо-гипофизарной области. В данном обзоре обсуждается общая концепция инвазивности аденом гипофиза, характеристика ММП и исследования, посвященные взаимосвязи данных молекул с инвазией аденом гипофиза.

Pituitary adenomas (PA) are the most common lesions of hypothalamic-pituitary region. Clinical presentations of PA depend on both hormonal activity and tumor growth characteristics. Despite the fact that PA are mostly benign, they can grow invasively and mechanically affect adjacent structures. With invasive growth of PA, radical removal is difficult and associated with a higher risk of surgical complications. Pathogenesis of PA invasiveness is not fully understood. Tumor cell invasion depends on both intercellular interactions within the tumor and interaction with extracellular matrix components (ECM). Major factors that play an important role in these processes include matrix metalloproteinase (MMP) family and tissue inhibitors of matrix metalloproteinases (TIMPs). Two MMPs were mostly studied in PA – types 2 and 9. These molecules are of interest, as they participate in degradation of type IV collagen, which is a key component of the ECM in hypothalamic-pituitary region. This review discusses the general concept of PA invasiveness, the characteristics of MMPs, and research of the relationship between these molecules and PA invasiveness.

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The authors declare that there are no conflicts of interest present.