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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl13817</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-13817</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical endocrinology</subject></subj-group></article-categories><title-group><article-title>Потеря волос на фоне лечения ожирения: современное состояние проблемы и потенциальные решения</article-title><trans-title-group xml:lang="en"><trans-title>Hair loss during treatment of obesity: current state of the problem and potential solutions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8520-8702</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трошина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Troshina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трошина Екатерина Анатольевна, д.м.н., профессор</p><p>Москва</p></bio><bio xml:lang="en"><p>Ekaterina A. Troshina, MD, Dr. Sc. (Med.),Professor</p><p>Moscow</p></bio><email xlink:type="simple">troshina@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9253-8075</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суплотова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Suplotova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суплотова Людмила Александровна, д.м.н., профессор</p><p>Тюмень</p></bio><bio xml:lang="en"><p>Lyudmila A. Suplotova, MD, Dr. Sc. (Med.), Professor</p><p>Tyumen</p></bio><email xlink:type="simple">suplotovala@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0327-4619</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзгоева</surname><given-names>Ф. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzgoeva</surname><given-names>F. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дзгоева Фатима Хаджимуратовна, к.м.н., доцент</p><p>117036, Москва, ул. Дм. Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Fatima K. Dzgoeva, MD, PhD</p><p>11 Dm. Ulyanova street, 117036 Moscow</p></bio><email xlink:type="simple">fatima.dzgoeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6762-5238</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руяткина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruyatkina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Руяткина Людмила Александровна, д.м.н., профессор</p><p>Москва</p></bio><bio xml:lang="en"><p>Lyudmila A. Ruyatkina, MD, Dr. Sc. (Med.), Professor</p><p>Novosibirsk</p></bio><email xlink:type="simple">larut@list.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0489-0576</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаджигороева</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gadzhigoroeva</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаджигороева Аида Гусейхановна, д.м.н., профессор</p><p>Москва</p></bio><bio xml:lang="en"><p>Aida G. Gadzhigoroeva, MD, Dr. Sc. (Med.), Professor</p><p>Moscow</p></bio><email xlink:type="simple">aida2010@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7663-710X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Громова Ольга Алексеевна, д.м.н., профессор</p><p>Москва</p><p>Иваново</p><p>WoS ResearcherID: J-4946-2017</p><p>Scopus Author ID: 7003589812</p></bio><bio xml:lang="en"><p>Olga A. Gromova, MD, Dr. Sc. (Med.), Professor</p><p>Moscow</p><p>Ivanovo</p><p>WoS ResearcherID: J-4946-2017</p><p>Scopus Author ID: 7003589812</p></bio><email xlink:type="simple">unesco.gromova@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6071-5145</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Романова Юлия Юрьевна, к.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>Yulia Yu. Romanova, MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">romanova.u@mosderm.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский центр эндокринологии им. академика И.И. Дедова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тюменский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Российский университет дружбы народов им. Патриса Лумумбы; Московский научно-практический Центр дерматовенерологии и косметологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Patrice Lumumba Peoples’ Friendship University; Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Федеральный исследовательский центр «Информатика и управление» Российской Академии Наук; Ивановский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center «Informatics and Control» of the Russian Academy of Sciences; Ivanovo State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Российский университет дружбы народов им. Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Patrice Lumumba Peoples’ Friendship University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>08</day><month>09</month><year>2026</year></pub-date><volume>72</volume><issue>4</issue><fpage>4</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трошина Е.А., Суплотова Л.А., Дзгоева Ф.Х., Руяткина Л.А., Гаджигороева А.Г., Громова О.А., Романова Ю.Ю., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Трошина Е.А., Суплотова Л.А., Дзгоева Ф.Х., Руяткина Л.А., Гаджигороева А.Г., Громова О.А., Романова Ю.Ю.</copyright-holder><copyright-holder xml:lang="en">Troshina E.A., Suplotova L.A., Dzgoeva F.K., Ruyatkina L.A., Gadzhigoroeva A.G., Gromova O.A., Romanova Y.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/13817">https://www.probl-endojournals.ru/jour/article/view/13817</self-uri><abstract><p>Ожирение и избыточная масса тела являются значимыми медико-социальными проблемами, а современные подходы к их лечению, включая гипокалорийные диеты, бариатрические вмешательства и фармакотерапию, в том числе препаратами инкретинового ряда (например, агонистами рецептора глюкагоноподобного пептида-1), могут сопровождаться развитием диффузного выпадения волос. Настоящая статья подготовлена по результатам обсуждения на совете экспертов и систематизирует современные данные о распространенности и клинико-морфологических вариантах алопеции на фоне снижения массы тела. Рассмотрены основные патогенетические механизмы, включая метаболический стресс, белково-энергетическую недостаточность и дефицит микронутриентов. Отдельное внимание уделено роли биотина и витамина D в поддержании функций волосяного фолликула, а также группам риска развития алопеции у пациентов, получающих лечение по поводу ожирения. Представлены подходы к профилактике, мониторингу и комплексному ведению таких пациентов с учетом необходимости сохранения приверженности основной терапии.</p><p>В статье систематизированы современные данные о распространенности и клинико-морфологических вариантах алопеции на фоне снижения массы тела, рассмотрены основные патогенетические механизмы, включая метаболический стресс, белково-энергетическую недостаточность и дефицит микронутриентов. Отдельное внимание уделено роли биотина и витамина D в поддержании функций волосяного фолликула, а также группам риска развития алопеции у пациентов, получающих лечение по поводу ожирения. Представлены подходы к профилактике, мониторингу и комплексному ведению таких пациентов с учетом необходимости сохранения приверженности основной терапии.</p></abstract><trans-abstract xml:lang="en"><p>Obesity and overweight are significant medical and social problems, and current approaches to their treatment, including hypocaloric diets, bariatric interventions, and pharmacotherapy, including incretin drugs (e.g., glucagon-like peptide-1 receptor agonists), can be accompanied by the development of diffuse hair loss. This article, prepared following a discussion at an expert council, systematizes current data on the prevalence and clinical and morphological variants of alopecia associated with weight loss. The main pathogenic mechanisms are discussed, including metabolic stress, protein-energy malnutrition, and micronutrient deficiencies.</p><p>Special attention is paid to the role of biotin and vitamin D in maintaining hair follicle function, as well as to risk groups for alopecia in patients undergoing treatment for obesity. Approaches to the prevention, monitoring, and comprehensive management of such patients are presented, taking into account the need to maintain adherence to the main therapy.</p><p>This article systematizes current data on the prevalence and clinical and morphological variants of alopecia associated with weight loss. It examines the main pathogenic mechanisms, including metabolic stress, protein-energy malnutrition, and micronutrient deficiencies. Special attention is paid to the role of biotin and vitamin D in maintaining hair follicle function, as well as to risk groups for alopecia in patients undergoing treatment for obesity. Approaches to prevention, monitoring, and comprehensive management of these patients are presented, taking into account the need to maintain adherence to the primary therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>избыточная масса тела</kwd><kwd>выпадение волос</kwd><kwd>алопеция</kwd><kwd>телогеновая алопеция</kwd><kwd>андрогенетическая алопеция</kwd><kwd>препараты инкретинового ряда</kwd><kwd>агонисты рецептора глюкагоноподобного пептида-1</kwd><kwd>биотин</kwd><kwd>витамин D</kwd><kwd>микронутриенты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>overweight</kwd><kwd>hair loss</kwd><kwd>alopecia</kwd><kwd>telogen effluvium</kwd><kwd>androgenetic alopecia</kwd><kwd>incretin-based therapies</kwd><kwd>glucagon-like peptide-1 receptor agonists</kwd><kwd>biotin</kwd><kwd>vitamin D</kwd><kwd>micronutrients</kwd></kwd-group></article-meta></front><back><ref-list><ref id="cit1"><mixed-citation publication-type="commun" publication-format="web"><source>Federal'naya sluzhba gosudarstvennoi statistiki (Rosstat)</source>. <article-title>Zdravookhranenie v Rossii 2025: statisticheskii sbornik</article-title>. — M.; <year>2025</year>. 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