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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl201258258-61</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-4596</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Преимущества применения гликлазида МВ у пациентов с сахарным диабетом 2-го типа</article-title><trans-title-group xml:lang="en"><trans-title>The advantages of the treatment of the patients with type 2 diabetes mellitus with gliclazide MR</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Pekareva</surname><given-names>E V</given-names></name></name-alternatives><email xlink:type="simple">pekarevaev@mail.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>04</month><year>2012</year></pub-date><volume>58</volume><issue>2</issue><issue-title>ТОМ 58, №2 (2012)</issue-title><fpage>58</fpage><lpage>61</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Pekareva E.V., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Pekareva E.V.</copyright-holder><copyright-holder xml:lang="en">Pekareva E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/4596">https://www.probl-endojournals.ru/jour/article/view/4596</self-uri><abstract><p>Сахарный диабет 2-го типа (СД2) - хроническое заболевание, характеризующееся прогрессирующей гипергликемией вследствие дисфункции Β-клеток и снижения секреции инсулина. Поддержание целевых показателей гликемии способствует не только сохранению пула Β-клеток, но и снижению риска сосудистых осложнений. Представлены результаты сравнения эффектов производных сульфонилмочевины у пациентов с СД2.</p></abstract><trans-abstract xml:lang="en"><p>Type 2 diabetes mellitus (DM2) is a chronic condition characterized by progressive hyperglycemia resulting from beta-cell dysfunction and impaired insulin secretion. The maintenance of the target blood glucose level not only promotes preservation of the beta-cell pool but also reduces the risk of the development and progression of vascular complications of diabetes. This paper is designed to report the results of comparative investigations of the application of sulphonylurea derivatives for the treatment of the patients with type 2 diabetes mellitus.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2-го типа</kwd><kwd>патогенез</kwd><kwd>производные сульфонилмочевины</kwd><kwd>гликлазид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes mellitus</kwd><kwd>pathogenesis</kwd><kwd>sulphonylurea derivatives</kwd><kwd>gliclazide</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven G.M. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.</mixed-citation><mixed-citation xml:lang="en">Reaven G.M. Role of insulin resistance in human disease. 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