problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl20115769-14problendo-4625Research ArticleСтатьиArticlesАдипонектин сыворотки крови при ожирении у детей и подростковSerum adiponectin in obese children and adolescentsPeterkovaV A-KosyginaA Vannakosygina@gmail.comVasiukovaO V-201115122011576ТОМ 57, №6 (2011)914Copyright © Peterkova V.A., Kosygina A.V., Vasiukova O.V., 20112011Peterkova V.A., Kosygina A.V., Vasiukova O.V.Peterkova V.A., Kosygina A.V., Vasiukova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/4625

Цель настоящей работы - изучение взаимосвязи концентрации адипонектина в сыворотке с возрастом, стадией полового развития и основными антропометрическими характеристиками детей и подростков, а также исследование содержания адипонектина в сыворотке детей в зависимости от степени ожирения и наличия метаболических осложнений. Обследованы 111 детей и подростков в возрасте от 2,5 до 17,9 года, из которых 56 - с "простым" конституционально-экзогенным ожирением, 12 - с избыточной массой тела и 43 - с нормальной массой тела. Концентрация адипонектина в сыворотке была ниже у детей и подростков с ожирением, чем у детей с нормальной массой тела (р=0,009). Наиболее высокий уровень адипонектина отмечается у детей в препубертате и прогрессивно снижается по мере полового развития. Уровень адипонектина в сыворотке отрицательно коррелируется с ИМТ, ОТ и SDS ИМТ. У детей с ожирением, осложненным инсулинорезистентностью, уровень адипонектина в сыворотке ниже, чем у детей с нормальными показателями базального и стимулированного ИРИ и индексами инсулинорезистентности HOMA-IR и ISI Matsuda. Обнаружена ассоциация уровня адипонектина с показателями ХС ЛПВП и ТГ. Полученные результаты позволяют предположить, что снижение уровня адипонектина является связующим звеном между ожирением, инсулинорезистентностью и атерогенными сдвигами в сыворотке уже в детском возрасте и может использоваться как дополнительный биомаркер для выявления группы высокого риска осложнений, ассоциированных с ожирением.

The objective of this work was to study the relationship between the serum adiponectin level on the one hand, and the age, stage of sexual development and main anthropometric characteristics of children and adolescents depending on the degree of obesity, the presence or absence of metabolic disorders on the other hand. A total of 111 children and adolescents at the age from 2.5 to 17.9 years were available for the examination including 56 presenting with "simple" constitutional exogenous obesity, 12 overweight patients, and 43 with normal body weight. The concentration of adiponectin in the serum of obese children and adolescents was lower than in those with normal body weight (p=0.009). The highest adiponectin level was documented in prepubertal children; it decreased progressively in the course of sexual development and negatively correlated with BMI, waist circumference---???---(WC), and BMI SDS. The children presenting with obesity complicated by insulin resistance, the serum adiponectin level was lower than in those having normal and stimulated immunoreactive insulin concentrations, HOMA-IR and Matsuda's ISI indices. The study revealed the relationship between serum adiponectin levels, concentrations of high density lipoprotein cholesterol and triglycerides. The data obtained give reason to conjecture that the reduction of serum adiponectin level may be a link connecting obesity, insulin resistance, and atherogenic changed in the serum developing as early as the childhood that can be used as an additional biomarker for the identification of a group of children and adolescents at high risk of complications associated with obesity.

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The authors declare that there are no conflicts of interest present.