problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl201157615-20problendo-4626Research ArticleСтатьиArticlesЭффективность применения инсулина гларгин в условиях реальной клинической практики: результаты наблюдательной программы LAURUS-2The efficacy of insulin glargine under real clinical practice conditions: results of the LAURUS-2 observational programSkudaevS A-VerbovaiaN I-201115122011576ТОМ 57, №6 (2011)1520Copyright © Skudaev S.A., Verbovaia N.I., 20112011Skudaev S.A., Verbovaia N.I.Skudaev S.A., Verbovaia N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/4626

Цель программы - оценка эффективности и безопасности применения инсулина гларгин (Лантус) в повседневной клинической практике у пациентов с СД 2-го типа (СД2), не достигших цели лечения на терапии двумя пероральными сахарснижающими препаратами в комбинации с инсулином НПХ и имеющих уровень гликированного гемоглобина >7,0%. Проанализированы данные 2395 пациентов (755 мужчин и 1640 женщин), из них 2157 пациентов (685 мужчин и 1472 женщины) были переведены на инсулин гларгин и 238 пациентов (70 мужчин и 168 женщин) продолжили получать инсулин НПХ. Пациентам в группе, получающей инсулин гларгин (Лантус), были предложены два алгоритма титрации дозы инсулина. Через 12 нед лечения отмечено достоверное снижение показателей углеводного обмена без увеличения риска гипогликемий. Таким образом, результаты программы свидетельствуют о большой эффективности и безопасности применения инсулина гларгин по сравнению с инсулином НПХ у больных с СД2. Использование простого алгоритма титрации и самоконтроля гликемии позволяет быстро, эффективно и безопасно достичь оптимальных показателей углеводного обмена у большинства пациентов, получающих Лантус, при меньшей частоте всех типов гипогликемий.

The objective of the Program is to estimate the efficacy and safety of insulin glargine (Lantus) used in routine clinical practice for the treatment of patients presenting with type 2 diabetes mellitus who failed to reach adequate compensation of the disease by therapy with two hyperglycemic agents in combination with NPH insulin and have a glycated hemoglobin level in excess of 7.0%. The data obtained by examining 2395 patients (755 men and 1640 women) were available for analysis. 2157 patients (685 men and 1472 women) were transferred to insulin glargine therapy whereas the remaining 238 ones (70 men and 168 women) continued to use NPH insulin. The patients of the former group were offered two algorithms for dose titration of glargine (Lantus). Significant improvement of the parameters of carbohydrate metabolism was achieved within 12 weeks after the onset of therapy without the risk of hypoglycemia. It is concluded that the results of the Program demonstrate a higher efficacy and safety of insulin glargine compared with NPH insulin for the treatment of the patients with type 2 diabetes mellitus. The use of a simple dose titration algorithm and glycemic self-control makes it possible to quickly, safely, and efficiently achieve optimal parameters of carbohydrate metabolism in the majority of the patients treated with insulin glargine at a low incidence of episodes of all types of hypoglycemia.

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The authors declare that there are no conflicts of interest present.