References

problendo

Проблемы Эндокринологии

Problems of Endocrinology

0375-96602308-1430

Endocrinology Research Centre

10.14341/probl201258557-65

problendo-4666

Research Article

Статьи

Articles

Стресс эндоплазматического ретикулума: цитологический сценарий патогенеза заболеваний человека

Stress of endoplasmic reticulum: the cytological "scenario" of pathogenesis of human diseases

Dedov

I I

Smirnova

O M

dr_smr@mail.ru

Gorelyshev

A S

2012

15102012

585

ТОМ 58, №5 (2012)

5765

2012

Dedov I.I., Smirnova O.M., Gorelyshev A.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.probl-endojournals.ru/jour/article/view/4666

Феномен "стресса" эндоплазматического ретикулума (ЭР) привлекает все большее внимание. Современные данные позволяют рассматривать дисфункцию ЭР как общее звено многих заболеваний человека, среди них - онкопатология, нейродегенеративные и вирусные заболевания. Особое значение перегрузка ЭР имеет для клеточных популяций, активно секретирующих белок, поскольку для развития стресса ЭР огромное значение имеет нарушение фолдинга белка. Это обстоятельство может сформировать новое понимание такого заболевания, как сахарный диабет. В данной работе обобщаются современные представления о биохимических основах стресса ЭР и рассматриваются ключевые сигнальные пути компенсации и проапоптоза.

The phenomenon of stress of endoplasmic reticulum (ER) attracts an increasingly higher attention of the researchers. The available data suggest that ER dysfunction is a common component of many human pathologies including oncological diseases and neurodegenerative viral diseases. Stress of ER is of special significance in the cell populations actively secreting proteins because protein folding disturbances play an important role in its development. This fact opens up prospects for the better understanding of pathogenesis of diabetes mellitus and some other diseases. The present work summarizes the current concepts of biochemical mechanisms underlying stress of endoplasmic reticulum and elucidates the key signal pathways for its compensation and proapoptosis.

стресс эндоплазматического ретикулумафолдинг белкасахарный диабетсигнальные пути

stress of endoplasmic reticulumprotein foldingdiabetes mellitussignaling mechanisms

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The authors declare that there are no conflicts of interest present.