problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl201258335-40problendo-4687Research ArticleСтатьиArticlesМелатонин и сахарный диабет (обзор современных экспериментальных данных)Melatonin and diabetes mellitus (an overview of current experimental data)ArushanianÉ Beduard.arush@mail.ru201215062012583ТОМ 58, №3 (2012)3540Copyright © Arushanian É.B., 20122012Arushanian É.B.Arushanian É.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/4687

Секретируемый эпифизом и апудоцитами желудочно-кишечного тракта мелатонин участвует в регуляции углеводного обмена, модулируя активность α- и Β-клеток островков Лангерганса поджелудочной железы через специфические мелатониновые рецепторы (МР1 и МР2). Уровни мелатонина и инсулина находятся в реципрокных отношениях, а дефицит мелатонина, очевидно, является одним из факторов патогенеза сахарного диабета. Мелатонин обеспечивает антидиабетическую защиту посредством различных клеточных и системных механизмов.

Melatonin secreted by the epiphysis and synthesized in adipocytes of the gastrointestinal tract participates in the regulation of carbohydrate metabolism by modulating activities of alpha- and beta cell of Langerhans islets in the pancreas; melatonin acts via its specific receptors (MT1 and MT2). Reciprocal interactions between melatonin and insulin have been demonstrated while melatonin deficiency is known to be one of the factors predisposing to the development of diabetes mellitus. It was shown that melatonin provides protection against diabetes through a variety of intracellular and systemic mechanisms.

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The authors declare that there are no conflicts of interest present.