problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl201258356-60problendo-4691Research ArticleСтатьиArticlesЗначение и преимущества своевременного назначения инсулина пациентам с сахарным диабетом 2-го типаThe importance and advantages of the timely prescription of insulin to the patients with type 2 diabetes mellitusIarek-MartynovaI Riwonamj@mail.ru201215062012583ТОМ 58, №3 (2012)5660Copyright © Iarek-Martynova I.R., 20122012Iarek-Martynova I.R.Iarek-Martynova I.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/4691

Своевременное начало инсулинотерапии при сахарном диабете 2-го типа (СД2) обеспечивает лучший гликемический контроль, снижает отрицательные последствия хронической глюкозотоксичности и липотоксичности. Достижение и поддержание стойкой компенсации заболевания являются главными условиями профилактики хронических осложнений СД. Согласно рекомендациям ADA, инсулинотерапию следует применять в начале заболевания, если это обусловлено клинической ситуацией, или присоединяя к терапии пероральными сахарснижающими препаратами (ПССП), когда не достигнуты целевые значения HbA1c, несмотря на применение одного таблетированного препарата или более.

The onset of insulin therapy is an important stage in the treatment of type 2 diabetes mellitus. Its timely beginning ensures better control of glycemia and reduces the negative consequences of chronic glucose cytotoxicity and lipotoxicity. The achievement and maintenance of the stable compensation of the disease are the indispensable conditions for successful prophylaxis and adequate treatment of chronic complications of diabetes mellitus. The ADA guidelines recommend to initiate insulin therapy at the early stages of the disease provided it is dictated by the clinical situation or combine it with the use of oral hypoglycemic agents if the targeted HbA1c levels fail to be reached despite the intake of one or more tableted preparations.

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The authors declare that there are no conflicts of interest present.