References

problendo

Проблемы Эндокринологии

Problems of Endocrinology

0375-96602308-1430

Endocrinology Research Centre

10.14341/probl201258161-66

problendo-4704

Research Article

Статьи

Articles

Ингибиторы дипептидилпептидазы-4: сравнительный анализ представителей группы

Dipeptidyl peptidase-4 inhibitors: Comparative analysis of members of the group

Shestakova

E A

katiashestakova@mail.ru

Galstian

G R

2012

15022012

581

ТОМ 58, №1 (2012)

6166

2012

Shestakova E.A., Galstian G.R.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.probl-endojournals.ru/jour/article/view/4704

Ингибиторы дипептидилпептидазы-4 (ДПП-4) - новый класс сахарснижающих препаратов, разработанных с учетом появившихся в XXI веке знаний о физиологии инкретинов. В настоящий момент появилось пять представителей данного класса, три из которых доступны на российском рынке. Ингибиторы ДПП-4 оказывают сахарснижающее действие за счет снижения тощаковой и постпрандиальной гипергликемии, не вызывают увеличения массы тела и имеют благоприятный профиль побочных эффектов. Тем не менее ингибиторы ДПП-4 отличаются по своей фармакодинамике и фармакокинетике, что обусловливает различия в длительности их действия, лекарственных взаимодействиях, возможности применения у отдельных категорий пациентов. В статье представлена сравнительная характеристика трех ингибиторов ДПП-4: вилдаглиптина, ситаглиптина и саксаглиптина.

Dipeptidyl peptidase-4 inhibitors (DPP-4) is a new class of hypoglycemic drugs developed based on the knowledge of incretin physiology acquired in the 21st century. Currently, five members of this group are in use three of which are available on the Russian market. The hypoglycemic effect of dipeptidyl peptidase-4 inhibitors is due to reduction of fasting and postprandial hyperglycemia without a rise in the body weight and acceptable profile of side effects. Dipeptidyl peptidase-4 inhibitors differ in terms of pharmacodynamics and pharmacokinetics which implies different indications and duration of their use in different groups of patients as well as different character of their drug interaction. This paper compares three dipeptidyl peptidase-4 inhibitors, viz. vildagliptin, sitagliptin, and saxagliptin.

ингибитор ДПП-4инкретинвилдаглиптинситаглиптинсаксаглиптин

dipeptidyl peptidase-4 inhibitorincretinvildagliptinsitagliptinsaxagliptin

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The authors declare that there are no conflicts of interest present.