References

problendo

Проблемы Эндокринологии

Problems of Endocrinology

0375-96602308-1430

Endocrinology Research Centre

10.14341/probl201056632-40

problendo-4722

Research Article

Статьи

Articles

"Внутриутробное программирование" гормонально-метаболических процессов и синдром задержки внутриутробного развития

"Intrauterine programming" of hormonal and metabolic processes and intrauterine growth retardation syndrome

Nagaeva

E V

nagaeva_ev@mail.ru

Shiriaeva

T Iu

2010

15122010

566

ТОМ 56, №6 (2010)

3240

2010

Nagaeva E.V., Shiriaeva T.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.probl-endojournals.ru/jour/article/view/4722

Гипотеза о "фетальном программировании" предполагает, что адаптация плода в ответ на недостаток питания приводит к стойким изменениям метаболизма, которые превращаются в предрасположенность к сердечно-сосудистым, метаболическим и эндокринным заболеваниям. К настоящему времени накоплено достаточно много катамнестических данных о том, что у людей с пренатальной задержкой роста в анамнезе в зрелом возрасте возможно развитие различных гормонально-метаболических нарушений: выявлена тесная связь между синдромом задержки внутриутробного развития и повышенным артериальным давлением, нарушенной толерантностью к глюкозе, метаболическим синдромом. В обзоре обобщены данные эпидемиологических и экспериментальных исследований, подтверждающие данную гипотезу.

According to the "intrauterine programming" hypothesis, the fetus responses to nutritional deficiency by adaptation in the form of long-standing changes of metabolism that eventually create predisposition to cardiovascular, metabolic, and endocrine diseases. Up to now, a wealth of catamnestic data have been gathered indicating that individuals having the history of growth retardation in the prenatal period are likely to develop a variety of hormonal and metabolic disorders when they reach their mature age. Specifically, there is the close relationship between the intrauterine growth retardation syndrome and elevated arterial pressure, impaired glucose tolerance, and metabolic syndrome. The present review summarizes the results of epidemiological and experimental studies that confirm the above hypothesis.

фетальное программированиезадержка внутриутробного развитиярост плоданутритивный статусметаболический синдром

fetal programmingintrauterine growth retardationfetal growthnutritional stressmetabolic syndrome

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The authors declare that there are no conflicts of interest present.