References

problendo

Проблемы Эндокринологии

Problems of Endocrinology

0375-96602308-1430

Endocrinology Research Centre

10.14341/probl201056655-62

problendo-4725

Research Article

Статьи

Articles

Применение ланреотида Аутожеля в лечении акромегалии

The application of lanreotide autogel for the treatment of acromegaly

Ilovaĭskaia

I A

ilov_enc@mail.ru

2010

15122010

566

ТОМ 56, №6 (2010)

5562

2010

Ilovaĭskaia I.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.probl-endojournals.ru/jour/article/view/4725

Ранняя диагностика акромегалии и своевременное назначение адекватного лечения имеют принципиальное значение для предотвращения нежелательных эффектов длительного воздействия на организм хронического избытка гормона роста и инсулиноподобного фактора роста 1-го типа. Более половины больных акромегалией нуждаются в длительном лечении аналогами соматостатина, которое снижает риск преждевременной смертности и помогает сохранить качество жизни. Новый аналог соматостатина ланреотид Аутожель, вошедший в клиническую практику за последние годы, эффективно снижает секрецию гормона роста и инсулиноподобного фактора роста 1-го типа, а также обладает способностью вызывать уменьшение объема соматотропином. Кроме того, препарат отличают хорошая переносимость, возможность увеличения интервала между инъекциями с 4 до 6-8 нед и технически простое подкожное введение, которое делает возможным самостоятельное проведение инъекций для большинства пациентов, поэтому применение ланреотида Аутожеля значительно расширяет возможности медицинской помощи при акромегалии.

The early diagnosis of acromegaly and timely initiation of the adequate treatment are of primary importance for the prevention of the undesired long-term effects of chronic overproduction of growth hormone and insulin-like growth factor-1. Over half of the patients presenting with acromegaly are in need of sustainable treatment with somatostatin analogs that reduces the risk of premature death and helps to maintain quality of life. The new somatostatin analog lanreotide autogel recently introduced into clinical practice is known to effectively diminish secretion of both growth hormone and insulin-like growth factor-1. Moreover, it shows the ability to decrease the volume of somatotropinoms and is well tolerated by the patients. The intervals between injections of lanreotide autogel can be prolonged from 4 to 6-8 weeks. Its subcutaneous administration is technically easy which enables the majority of the patients to perform self-injections. Taken together, these advantages of lanreotide autogel considerably extend the opportunities for medical aid to the patients with acromegaly.

акромегалиямедикаментозное лечениеаналоги соматостатиналанреотид Аутожель

acromegalymedicamental treatmentsomatostatin analogslanreotide Autogel

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The authors declare that there are no conflicts of interest present.