problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl201056663-72problendo-4726Research ArticleСтатьиArticlesПодходы к рациональному выбору ингибиторов фосфодиэстеразы 5-го типа у пациентов с сердечно-сосудистыми и эндокринными заболеваниямиApproaches to the rational choice of type 5 phosphodiesterase inhibitors in patients presenting with cardiovascular and endocrine diseasesRafal'skiĭV Vv.rafalskiy@mail.ruBaglikovA N-201015122010566ТОМ 56, №6 (2010)6372Copyright © Rafal'skiĭ V.V., Baglikov A.N., 20102010Rafal'skiĭ V.V., Baglikov A.N.Rafal'skiĭ V.V., Baglikov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/4726

После появления на лекарственном рынке четырех ингибиторов фосфодиэстеразы 5-го типа (ИФДЭ5) - силденафила, тадалафила, варденафила и уденафила, предназначенных для лечения эректильной дисфункции, перед врачами и пациентами встал вопрос о выборе среди них наиболее оптимального препарата. В статье проводится сравнение эффективности и безопасности различных ИФДЭ5, обсуждаются подходы к их рациональному выбору при лечении у пациентов с сердечно-сосудистыми и эндокринными заболеваниями. В сравнительных контролируемых исследованиях не получено достоверных данных о более высокой эффективности и безопасности того или иного препарата из этой группы. Тем не менее имеющиеся на сегодняшний день данные позволяют говорить о более высокой комплаентности при приеме варденафила и тадалафила. Указывается на целесообразность применения варденафила при наличии фоновой патологии. Отмечается высокий профиль безопасности всех представителей ИФДЭ5, однако для варденафила не характерны типичные нежелательные реакции.

After the advent of four type 5 phosphodiesterase inhibitors (PDEI 5), viz. sildenafil, tadalafil, vardenafil, and udenafil, designed for the treatment of erectile dysfunction both physicians and patients found themselves faced with the problem of choosing an optimal therapeutic option. This paper contains comparative data on the efficacy and safety of different PDEI 5. The approaches to the rational choice of these preparations for the treatment of patients presenting with cardiovascular and endocrine diseases are discussed. Comparative controlled clinical studies failed to yield definitive information about advantages of one or another agent representing this group of pharmaceutical products. Nevertheless, the currently available data permit to draw the conclusion that the use of vardenafil and tadalafil ensures better compliance of patients with the prescribed therapy. Certain authors advocate the desirability of vardenafil application to the treatment of patients presenting with a background pathology. It is emphasized that all available PDEI 5 have a beneficial safety profile, with wardenafil being virtually free from adverse side effects.

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The authors declare that there are no conflicts of interest present.