References

problendo

Проблемы Эндокринологии

Problems of Endocrinology

0375-96602308-1430

Endocrinology Research Centre

10.14341/probl201157353-59

problendo-4745

Research Article

Статьи

Articles

Базальная инсулинотерапия у пациентов с сахарным диабетом 2-го типа: аспекты раннего назначения, преимущества, ограничения, перспективы

Basal insulin therapy in patients with type 2 diabetes mellitus: aspects of early initiation, advantages, constraints, and prospects

Vikulova

O K

Olga-Vikulova-1973@yandex.ru

2011

15062011

573

ТОМ 57, №3 (2011)

5359

2011

Vikulova O.K.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.probl-endojournals.ru/jour/article/view/4745

Интенсивный контроль гликемии непосредственно с дебюта сахарного диабета 2-го типа (СД2) имеет приоритетное значение для снижения риска и долгосрочного прогноза сердечно-сосудистых осложнений. Стратегия ранней интенсификации терапии СД2 с помощью инсулина до настоящего времени остается предметом острых дискуссий. Выбор оптимального режима для старта инсулинотерапии также не имеет однозначного решения. Гипогликемии являются основным фактором, традиционно ограничивающим более широкое применение инсулинотерапии у пациентов с СД2. Выбор в пользу базальной инсулинотерапии аналогами инсулина имеет преимущества в достижении целевых показателей углеводного обмена при значимо меньшем риске гипогликемий по сравнению с другими режимами инсулинотерапии.

Intensive control of glycemia starting from the onset of type 2 diabetes mellitus (DM2) is of primary importance for the long-term prognosis of the disease and the reduction of risk of cardiovascular complications. The strategy of early intensive therapy of DM2 thus far remains a matter of fierce dispute among diabetologists. The problem of choice of an optimal regime for the start of insulin therapy does not have an unambiguous solution either. Hypoglycemia is the main factor that traditionally hampers wide application of insulin therapy in patients with type 2 diabetes mellitus. The choice in favour of basal therapy with insulin analogs has the advantage of reaching the target parameters of carbohydrate metabolism at a significantly lower risk of hypoglycemia compared with other strategies of insulin therapy.

сахарный диабет 2-го типасердечно-сосудистый рискинсулинотерапияинсулин гларгин

type 2 diabetes mellituscardiovascular risksinsulin therapyinsulin glargine

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The authors declare that there are no conflicts of interest present.