References

problendo

Проблемы Эндокринологии

Problems of Endocrinology

0375-96602308-1430

Endocrinology Research Centre

10.14341/probl201258624-32

problendo-60

Research Article

Статьи

Articles

Эндокринная офтальмопатия: современный взгляд

Endocrine ophthalmopathy: state-of-the-art approaches

Petunina

N. A.

narinarine@list.ru

Trukhina

L. V.

narinarine@list.ru

Martirosyan

N. S.

narinarine@list.ru

ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» МЗ РФ, МоскваРоссияSechenov First Moscow State Medical Univesity, MoscowRussian Federation

2012

14052013

5862432

2012

Petunina N.A., Trukhina L.V., Martirosyan N.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.probl-endojournals.ru/jour/article/view/60

Обсуждаются вопросы этиологии, патогенеза, клинических проявлений и лечения эндокринной офтальмопатии (ЭОП). ЭОП — гетерогенное аутоиммунное заболевание глаз, которое чаще всего ассоциировано с болезнью Грейвса, но также встречается при хроническом аутоиммунном тиреоидите и в отсутствие дисфункции щитовидной железы. Хотя патогенез ЭОП остается не до конца ясным, несомненной является ее аутоиммунная природа с участием сенсибилизированных Т-лимфоцитов и аутоантител к тканям орбиты. Понимание механизмов развития ЭОП привело к появлению новых групп препаратов, действующих селективно на различные звенья патогенеза. Управление ЭОП остается сложной задачей, требующей мультидисциплинарного подхода.

The issues pertaining to etiology, pathogenesis, clinical manifestations, and treatment of endocrine ophthalmopathy (EOP) are discussed. EOP is a heterogeneous autoimmune eye disease most frequently associated with Graves’ disease even though it is just as well encountered both in the patients presenting with chronic autoimmune thyroiditis and in the absence of thyroid dysfunction. Although pathogenesis of EOP remains to be elucidated its autoimmune nature with the involvement of sensitized T-lymphocytes and autoantibodies against orbital tissues leaves no doubt. The understanding of mechanisms underlying the development of EOP gave impetus to the creation of new groups of medicines selectively acting on various pathogenic processes associated with this disease. The management of EOP remains a challenging problem requiring a multi-disciplinary approach for its solution.

эндокринная офтальмопатияорбитопатия Грейвсаэкзофтальмритуксимаб

endocrine ophthalmopathyGraves’ orbitopathyexophthalmusrituximab

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The authors declare that there are no conflicts of interest present.