problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl201460315-22problendo-6904Research ArticleСтатьиArticlesСостояние гуанилатциклазного механизма вазодилатации до и после тиреоидэктомии при токсическом зобеThe state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiterИльичеваЕ АIlyichevaE Alena_isi@mail.ruТарнуеваИ ФTarnuevaI Feditorial@endocrincentr.ruПивоваровЮ ИPivovarovYu Ieditorial@endocrincentr.ruКорякинаЛ БKoryakinaL Beditorial@endocrincentr.ruЧижоваЕ АChizhovaE Aeditorial@endocrincentr.ruФГБУ «Научный центр реконструктивной и восстановительной хирургии» СО РАМН, ИркутскРоссияScientific center of reconstructive and restorative surgery of the Siberian branch of the Russian Academy of Medical Science, IrkutskRussian Federation201415062014603ТОМ 60, №3 (2014)1522Copyright © Ильичева Е.А., Тарнуева И.Ф., Пивоваров Ю.И., Корякина Л.Б., Чижова Е.А., 20142014Ильичева Е.А., Тарнуева И.Ф., Пивоваров Ю.И., Корякина Л.Б., Чижова Е.А.Ilyicheva E.A., Tarnueva I.F., Pivovarov Y.I., Koryakina L.B., Chizhova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/6904

Состояние гуанилатциклазной активности миоцитов, оцененное по приросту диаметра плечевой артерии в ответ на экзогенное введение нитроглицерина (δDNO) определялось у 44 больных в 64 пробах. Выполнено 23 исследования в декомпенсации тиреотоксикоза, 28 - в состоянии медикаментозной компенсации тиреотоксикоза, 13 - через 5-6 сут после тиреоидэктомии. Величина гуанилатциклазной активности миоцитов согласовывалась с продукцией факторов сосудистого эндотелия. Удаление щитовидной железы больным токсическим зобом на фоне сниженной гуанилатциклазной активности миоцитов сопровождается статистически значимым увеличением эндотелийнезависимой вазодилатации.

The state of the guanylate cyclase activity of myocytes was evaluated from the increment in the diameter of the brachial artery in response to the exogenous administration of nitroglycerin (#D^NO) in 64 samples obtained from 44 patients. A total of 23 studies were carried out during thyrotoxicosis decompensation, 28 ones in the phase of medicamental thyrotoxicosis, and 13 within 5-6 days after thyroidectomy. The guanylate cyclase activity of myocytes was found to correlate with the production of vascular endothelium factors. Thyroidectomy in the patients with toxic goiter and reduced guanylate cyclase activity of myocytes was associated with the statistically significant increase of endothelium-independent vasodilatation.

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The authors declare that there are no conflicts of interest present.