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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl201460667-77</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-7057</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Федеральные клинические рекомендации по диагностике и лечению токсического зоба</article-title><trans-title-group xml:lang="en"><trans-title>The federal clinical recommendations on diagnostics and treatment of toxic goiter</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трошина</surname><given-names>Е А</given-names></name><name name-style="western" xml:lang="en"><surname>Troshina</surname><given-names>Ekaterina A</given-names></name></name-alternatives><email xlink:type="simple">troshina@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свириденко</surname><given-names>Н Ю</given-names></name><name name-style="western" xml:lang="en"><surname>Sviridenko</surname><given-names>Natalya Yu</given-names></name></name-alternatives><email xlink:type="simple">editorial@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ванушко</surname><given-names>В Э</given-names></name><name name-style="western" xml:lang="en"><surname>Vanushko</surname><given-names>Vladimir E</given-names></name></name-alternatives><email xlink:type="simple">vanushko@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>П О</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantsev</surname><given-names>Pavel O</given-names></name></name-alternatives><email xlink:type="simple">editorial@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фадеев</surname><given-names>В В</given-names></name><name name-style="western" xml:lang="en"><surname>Fadeev</surname><given-names>Valentin V</given-names></name></name-alternatives><email xlink:type="simple">Walfad@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петунина</surname><given-names>Н А</given-names></name><name name-style="western" xml:lang="en"><surname>Petunina</surname><given-names>Nina A</given-names></name></name-alternatives><email xlink:type="simple">editorial@endocrincentr.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Эндокринологический научный центр» Минздрава России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый московский государственный медицинский университет им. И.М. Сеченова», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «Эндокринологический научный центр» Минздрава России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2014</year></pub-date><volume>60</volume><issue>6</issue><issue-title>ТОМ 60, №6 (2014)</issue-title><fpage>67</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трошина Е.А., Свириденко Н.Ю., Ванушко В.Э., Румянцев П.О., Фадеев В.В., Петунина Н.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Трошина Е.А., Свириденко Н.Ю., Ванушко В.Э., Румянцев П.О., Фадеев В.В., Петунина Н.А.</copyright-holder><copyright-holder xml:lang="en">Troshina E.A., Sviridenko N.Y., Vanushko V.E., Rumyantsev P.O., Fadeev V.V., Petunina N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/7057">https://www.probl-endojournals.ru/jour/article/view/7057</self-uri><abstract><p>Клинические рекомендации обсуждают современные подходы к диагностике и лечению заболеваний, протекающих с тиреотоксикозом.</p></abstract><trans-abstract xml:lang="en"><p>The proposed clinical recommendations discuss the modern approaches to diagnostics and treatment of the diseases with the clinical picture of thyrotoxicosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>щитовидная железа</kwd><kwd>болезнь Грейвса</kwd><kwd>многоузловой токсический зоб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thyroid gland</kwd><kwd>Graves’ disease</kwd><kwd>toxic multinodular goiter</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А., Свириденко Н.Ю. Платонова Н.М., Молашенко Н.В., Егоров А.В. Диагностика, лечение и профилактика ятрогенных йодиндуцированных заболеваний щитовидной железы // Вестник Российской Академии Медицинских Наук. – 2006. – №2. – С. 15-22. [ Dedov II, Melnichenko GA, Sviridenko NY, Platonova NM, Molashenko NV, Yegorov AV. Diagnostics, treatment, and prevention of iatrogenic iodine-induced thyroid gland diseases. Vestn Ross Akad Med Nauk 2006;(2):15-22.]</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А., Свириденко Н.Ю. Платонова Н.М., Молашенко Н.В., Егоров А.В. Диагностика, лечение и профилактика ятрогенных йодиндуцированных заболеваний щитовидной железы // Вестник Российской Академии Медицинских Наук. – 2006. – №2. – С. 15-22. [ Dedov II, Melnichenko GA, Sviridenko NY, Platonova NM, Molashenko NV, Yegorov AV. Diagnostics, treatment, and prevention of iatrogenic iodine-induced thyroid gland diseases. Vestn Ross Akad Med Nauk 2006;(2):15-22.]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: «ГЭОТАР –Медиа»; 2009. - 422 с. [ Dedov II, Mel'nichenko GA, Fadeyev VV. Endocrinology. Moscow: «GEOTAR–Media»; 2009.]</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: «ГЭОТАР –Медиа»; 2009. - 422 с. [ Dedov II, Mel'nichenko GA, Fadeyev VV. Endocrinology. Moscow: «GEOTAR–Media»; 2009.]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: Медицина; 2000. - С. 172-179. [ Dedov I.I., Mel'nichenko G.A., Fadeyev V.V. Endocrinology. Moscow: Meditsina; 2000.]</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: Медицина; 2000. - С. 172-179. [ Dedov I.I., Mel'nichenko G.A., Fadeyev V.V. Endocrinology. Moscow: Meditsina; 2000.]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и лечение заболевания щитовидной железы во время беременности и в послеродовом периоде: по материалам клинических рекомендаций эндокринологической ассоциации США. / Перевод и комментарии В. В. Фадеева. 2007. Режим доступа: http://www.thyronet.rusmedserv.com/ [Diagnosis and treatment of thyroid disease during pregnancy and the postpartum period: based on American Association of Clinical Endocrinologists. Translation and Commentary by Fadeyev V.V. 2007.]</mixed-citation><mixed-citation xml:lang="en">Диагностика и лечение заболевания щитовидной железы во время беременности и в послеродовом периоде: по материалам клинических рекомендаций эндокринологической ассоциации США. / Перевод и комментарии В. В. Фадеева. 2007. Режим доступа: http://www.thyronet.rusmedserv.com/ [Diagnosis and treatment of thyroid disease during pregnancy and the postpartum period: based on American Association of Clinical Endocrinologists. Translation and Commentary by Fadeyev V.V. 2007.]</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Menconi F, Marccci C, Marino M. Diagnosis and classification of Graves’ disease. Autoimmun Revews. 2014;13(4W5):398W402. doi: 10.1016/j.autrev.2014.01.013</mixed-citation><mixed-citation xml:lang="en">Menconi F, Marccci C, Marino M. Diagnosis and classification of Graves’ disease. Autoimmun Revews. 2014;13(4W5):398W402. doi: 10.1016/j.autrev.2014.01.013</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мельниченко Г.А. Болезни щитовидной железы и беременность: В кн.: Болезни органов эндокринной системы (руководство по внутренним болезням) / Под ред. И.И. Дедова. — М.: Медицина, 2002. [Mel'nichenko G.A. Thyroid Disease and Pregnancy. In book: Diseases of the endocrine system (manual of internal medicine). Ed by I.I. Dedov. Moscow: Meditsina; 2002.]</mixed-citation><mixed-citation xml:lang="en">Мельниченко Г.А. Болезни щитовидной железы и беременность: В кн.: Болезни органов эндокринной системы (руководство по внутренним болезням) / Под ред. И.И. Дедова. — М.: Медицина, 2002. [Mel'nichenko G.A. Thyroid Disease and Pregnancy. In book: Diseases of the endocrine system (manual of internal medicine). Ed by I.I. Dedov. Moscow: Meditsina; 2002.]</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Свириденко Н.Ю., Платонова Н.М., Молашенко Н.В., Голицин С.П., Бакалов С.А., Сердюк С.Е. Эндокринные аспекты применения амиодарона в клинической практике. (Алгоритм наблюдения и лечения функциональных расстройств щитовидной железы) // Российский кардиологический журнал. – 2012. – №2. – С. 63–71. [ Sviridenko NY, Platonova NM, Molashenko NV, Golitsyn SP, Bakalov SA, Serdyuk SE. Endocrine aspects of amiodarone therapy in clinical practice (Follow-up and treatment algorithm for patients with thyroid dysfunction). Rossiĭskiĭ kardiologicheskiĭ zhurnal 2012;(2):63-71.]</mixed-citation><mixed-citation xml:lang="en">Свириденко Н.Ю., Платонова Н.М., Молашенко Н.В., Голицин С.П., Бакалов С.А., Сердюк С.Е. Эндокринные аспекты применения амиодарона в клинической практике. (Алгоритм наблюдения и лечения функциональных расстройств щитовидной железы) // Российский кардиологический журнал. – 2012. – №2. – С. 63–71. [ Sviridenko NY, Platonova NM, Molashenko NV, Golitsyn SP, Bakalov SA, Serdyuk SE. Endocrine aspects of amiodarone therapy in clinical practice (Follow-up and treatment algorithm for patients with thyroid dysfunction). Rossiĭskiĭ kardiologicheskiĭ zhurnal 2012;(2):63-71.]</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Свириденко Н.Ю. Функциональная автономия щитовидной железы // Врач. – 2002. – №6. - C.8-11. [Sviridenko NY. Funktsional'naya avtonomiya shchitovidnoy zhelezy. Vrach 2002;(6):8-11.]</mixed-citation><mixed-citation xml:lang="en">Свириденко Н.Ю. Функциональная автономия щитовидной железы // Врач. – 2002. – №6. - C.8-11. [Sviridenko NY. Funktsional'naya avtonomiya shchitovidnoy zhelezy. Vrach 2002;(6):8-11.]</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Свириденко Н.Ю., Беловалова И.М., Шеремета М.С., Табеева К.И., Ремизов О.В. Болезнь Грейвса и эндокринная офтальмопатия. / Под ред. акад. РАН и РАМН И.И. Дедова и акад. РАМН Г.А. Мельниченко. М.: МАИ-принт; 2012. [Sviridenko NY, Belovalova IM, Sheremeta MS, Tabeeva KI, Remizov OV. Graves' disease and endocrine ophthalmopathy. Ed by I.I. Dedov and G.A. Mel'nichenko. Moscow: MAI-print; 2012.]</mixed-citation><mixed-citation xml:lang="en">Свириденко Н.Ю., Беловалова И.М., Шеремета М.С., Табеева К.И., Ремизов О.В. Болезнь Грейвса и эндокринная офтальмопатия. / Под ред. акад. РАН и РАМН И.И. Дедова и акад. РАМН Г.А. Мельниченко. М.: МАИ-принт; 2012. [Sviridenko NY, Belovalova IM, Sheremeta MS, Tabeeva KI, Remizov OV. Graves' disease and endocrine ophthalmopathy. Ed by I.I. Dedov and G.A. Mel'nichenko. Moscow: MAI-print; 2012.]</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Свириденко Н.Ю., Лихванцева В.Г., Беловалова И.М., Шеремета М.С., Табеева К.И. Антитела к рецептору ТТГ как предикторы тяжести и исходов эндокринной офтальмопатии у пациентов с болезнью Грейвса. // Проблемы эндокринологии. – 2011. – Т. 57. – №2. – C. 23-26. [ Sviridenko NI, Likhvantseva VG, Belovalova IM, Sheremeta MS, Tabeeva KI. Anti-TSH receptor antibodies as predictors of the severity and outcome of endocrine ophthalmopathy in the patients presenting with Graves' disease. Problemy endocrinologii 2011;57(2):23-26.] doi: 10.14341/probl201157223-26</mixed-citation><mixed-citation xml:lang="en">Свириденко Н.Ю., Лихванцева В.Г., Беловалова И.М., Шеремета М.С., Табеева К.И. Антитела к рецептору ТТГ как предикторы тяжести и исходов эндокринной офтальмопатии у пациентов с болезнью Грейвса. // Проблемы эндокринологии. – 2011. – Т. 57. – №2. – C. 23-26. [ Sviridenko NI, Likhvantseva VG, Belovalova IM, Sheremeta MS, Tabeeva KI. Anti-TSH receptor antibodies as predictors of the severity and outcome of endocrine ophthalmopathy in the patients presenting with Graves' disease. Problemy endocrinologii 2011;57(2):23-26.] doi: 10.14341/probl201157223-26</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Фадеев В.В., Абрамова Н.А., Прокофьев С.А., Гитель Е.П., Мельниченко Г.А., Дедов И.И. Антитела к рецептору ТТГ в дифференциальной диагностике токсического зоба // Проблемы эндокринологии. - 2005. - Т. 51. – №4. - С. 10-18. [Fadeyev VV, Abramova NA, Prokof'ev SA, Gitel' EP, Mel'nichenko GA, Dedov II. TSH receptor antibodies in the differential diagnosis of toxic goiter // Problemy endokrinologii 2005;51(4):10-18.]</mixed-citation><mixed-citation xml:lang="en">Фадеев В.В., Абрамова Н.А., Прокофьев С.А., Гитель Е.П., Мельниченко Г.А., Дедов И.И. Антитела к рецептору ТТГ в дифференциальной диагностике токсического зоба // Проблемы эндокринологии. - 2005. - Т. 51. – №4. - С. 10-18. [Fadeyev VV, Abramova NA, Prokof'ev SA, Gitel' EP, Mel'nichenko GA, Dedov II. TSH receptor antibodies in the differential diagnosis of toxic goiter // Problemy endokrinologii 2005;51(4):10-18.]</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Фадеев В.В., Дроздовский Б.Я., Гусева Т.Н., Гарбузов П.И., Бузиашвили И.И., Мельниченко Г.А. Отдалённые результаты лечения токсического зоба радиоактивным 131I // Проблемы эндокринологии. - 2005. - Т. 51. – №1. - С. 3-9. [Fadeyev VV, Drozdovskiy BY, Guseva TN, Garbuzov PI, Buziashvili II, Mel'nichenko GA. Long-term results of treatment of toxic goiter with radioactive 131I. Problemy endokrinologii 2005;51(1):3-9.]</mixed-citation><mixed-citation xml:lang="en">Фадеев В.В., Дроздовский Б.Я., Гусева Т.Н., Гарбузов П.И., Бузиашвили И.И., Мельниченко Г.А. Отдалённые результаты лечения токсического зоба радиоактивным 131I // Проблемы эндокринологии. - 2005. - Т. 51. – №1. - С. 3-9. [Fadeyev VV, Drozdovskiy BY, Guseva TN, Garbuzov PI, Buziashvili II, Mel'nichenko GA. Long-term results of treatment of toxic goiter with radioactive 131I. Problemy endokrinologii 2005;51(1):3-9.]</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al. Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593-646. doi: 10.1089/thy.2010.0417</mixed-citation><mixed-citation xml:lang="en">Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al. Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593-646. doi: 10.1089/thy.2010.0417</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bartalena L, Tanda ML, Piantanida E, Lai A. Glucocorticoids and outcome of radioactive iodine therapy for Graves' hyperthyroidism. European Journal of Endocrinology. 2005;153(1):13-14. doi: 10.1530/eje.1.01938</mixed-citation><mixed-citation xml:lang="en">Bartalena L, Tanda ML, Piantanida E, Lai A. Glucocorticoids and outcome of radioactive iodine therapy for Graves' hyperthyroidism. European Journal of Endocrinology. 2005;153(1):13-14. doi: 10.1530/eje.1.01938</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cawood TJ, Moriarty P, O’Farrelly C, O’Shea D. Smoking and Thyroid-Associated Ophthalmopathy: A Novel Explanation of the Biological Link. The Journal of Clinical Endocrinology &amp; Metabolism. 2007;92(1):59-64. doi: 10.1210/jc.2006-1824</mixed-citation><mixed-citation xml:lang="en">Cawood TJ, Moriarty P, O’Farrelly C, O’Shea D. Smoking and Thyroid-Associated Ophthalmopathy: A Novel Explanation of the Biological Link. The Journal of Clinical Endocrinology &amp; Metabolism. 2007;92(1):59-64. doi: 10.1210/jc.2006-1824</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, et al. Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology &amp; Metabolism. 2012;97(8):2543-2565. doi: 10.1210/jc.2011-2803</mixed-citation><mixed-citation xml:lang="en">De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, et al. Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology &amp; Metabolism. 2012;97(8):2543-2565. doi: 10.1210/jc.2011-2803</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Esfahani AF, Kakhki VR, Fallahi B, Eftekhari M, Beiki D, Saghari M, et al. Comparative evaluation of two fixed doses of 185 and 370 MBq 131I, for the treatment of Graves' disease resistant to antithyroid drugs. Hellenic Journal of Nuclear Medicine. 2005;8(3):158-161.</mixed-citation><mixed-citation xml:lang="en">Esfahani AF, Kakhki VR, Fallahi B, Eftekhari M, Beiki D, Saghari M, et al. Comparative evaluation of two fixed doses of 185 and 370 MBq 131I, for the treatment of Graves' disease resistant to antithyroid drugs. Hellenic Journal of Nuclear Medicine. 2005;8(3):158-161.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fadeyev V. Clinical Aspects of Thyroid Disorders in the Elderly. Thyroid Int. 2007 (3):3-15.</mixed-citation><mixed-citation xml:lang="en">Fadeyev V. Clinical Aspects of Thyroid Disorders in the Elderly. Thyroid Int. 2007 (3):3-15.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ginsberg J. Diagnosis and management of Graves' disease. Canadian Medical Association Journal. 2003 March 4, 2003;168(5):575-585.</mixed-citation><mixed-citation xml:lang="en">Ginsberg J. Diagnosis and management of Graves' disease. Canadian Medical Association Journal. 2003 March 4, 2003;168(5):575-585.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Järhult J, Rudberg C, Larsson E, Selvander H, Sjövall K, Winsa B, et al. Graves' Disease with Moderate–Severe Endocrine Ophthalmopathy–Long Term Results of a Prospective, Randomized Study of Total or Subtotal Thyroid Resection. Thyroid. 2005;15(10):1157-1164. doi: 10.1089/thy.2005.15.1157</mixed-citation><mixed-citation xml:lang="en">Järhult J, Rudberg C, Larsson E, Selvander H, Sjövall K, Winsa B, et al. Graves' Disease with Moderate–Severe Endocrine Ophthalmopathy–Long Term Results of a Prospective, Randomized Study of Total or Subtotal Thyroid Resection. Thyroid. 2005;15(10):1157-1164. doi: 10.1089/thy.2005.15.1157</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lal G, Ituarte P, Kebebew E, Siperstein A, Duh Q-Y, Clark OH. Should Total Thyroidectomy Become the Preferred Procedure for Surgical Management of Graves' Disease? Thyroid. 2005;15(6):569-574. doi: 10.1089/thy.2005.15.569</mixed-citation><mixed-citation xml:lang="en">Lal G, Ituarte P, Kebebew E, Siperstein A, Duh Q-Y, Clark OH. Should Total Thyroidectomy Become the Preferred Procedure for Surgical Management of Graves' Disease? Thyroid. 2005;15(6):569-574. doi: 10.1089/thy.2005.15.569</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lepner U, Seire I, Palmiste V, Kirsimägi Ü. Surgical treatment of Graves’ disease: subtotal thyroidectomy might still be the preferred option. Medicina (Kaunas, Lithuania). 2008;44(1):22-26.</mixed-citation><mixed-citation xml:lang="en">Lepner U, Seire I, Palmiste V, Kirsimägi Ü. Surgical treatment of Graves’ disease: subtotal thyroidectomy might still be the preferred option. Medicina (Kaunas, Lithuania). 2008;44(1):22-26.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mandel SJ, Cooper DS. The Use of Antithyroid Drugs in Pregnancy and Lactation. The Journal of Clinical Endocrinology &amp; Metabolism. 2001 2001/06/01;86(6):2354-2359. doi: 10.1210/jcem.86.6.7573</mixed-citation><mixed-citation xml:lang="en">Mandel SJ, Cooper DS. The Use of Antithyroid Drugs in Pregnancy and Lactation. The Journal of Clinical Endocrinology &amp; Metabolism. 2001 2001/06/01;86(6):2354-2359. doi: 10.1210/jcem.86.6.7573</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Manji N, Carr-Smith JD, Boelaert K, Allahabadia A, Armitage M, Chatterjee VK, et al. Influences of Age, Gender, Smoking, and Family History on Autoimmune Thyroid Disease Phenotype. The Journal of Clinical Endocrinology &amp; Metabolism. 2006;91(12):4873-4880. doi: 10.1210/jc.2006-1402</mixed-citation><mixed-citation xml:lang="en">Manji N, Carr-Smith JD, Boelaert K, Allahabadia A, Armitage M, Chatterjee VK, et al. Influences of Age, Gender, Smoking, and Family History on Autoimmune Thyroid Disease Phenotype. The Journal of Clinical Endocrinology &amp; Metabolism. 2006;91(12):4873-4880. doi: 10.1210/jc.2006-1402</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Menconi F, Marinò M, Pinchera A, Rocchi R, Mazzi B, Nardi M, et al. Effects of Total Thyroid AblationVersusNear-Total Thyroidectomy Alone on Mild to Moderate Graves’ Orbitopathy Treated with Intravenous Glucocorticoids. The Journal of Clinical Endocrinology &amp; Metabolism. 2007;92(5):1653-1658. doi: 10.1210/jc.2006-1800</mixed-citation><mixed-citation xml:lang="en">Menconi F, Marinò M, Pinchera A, Rocchi R, Mazzi B, Nardi M, et al. Effects of Total Thyroid AblationVersusNear-Total Thyroidectomy Alone on Mild to Moderate Graves’ Orbitopathy Treated with Intravenous Glucocorticoids. The Journal of Clinical Endocrinology &amp; Metabolism. 2007;92(5):1653-1658. doi: 10.1210/jc.2006-1800</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">The European Group of Graves’ Orbitopathy; Perros P, Baldeschi L, Boboridis K, Dickinson AJ, Hullo A, et al. A questionnaire survey on the management of Graves' orbitopathy in Europe. European Journal of Endocrinology. 2006;155(2):207-211. doi: 10.1530/eje.1.02201</mixed-citation><mixed-citation xml:lang="en">The European Group of Graves’ Orbitopathy; Perros P, Baldeschi L, Boboridis K, Dickinson AJ, Hullo A, et al. A questionnaire survey on the management of Graves' orbitopathy in Europe. European Journal of Endocrinology. 2006;155(2):207-211. doi: 10.1530/eje.1.02201</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Prummel M, Bakker A, Wiersinga W, Baldeschi L, Mourits M, Kendall-Taylor P, et al. Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience. European Journal of Endocrinology. 2003;148(5):491-495. doi: 10.1530/eje.0.1480491</mixed-citation><mixed-citation xml:lang="en">Prummel M, Bakker A, Wiersinga W, Baldeschi L, Mourits M, Kendall-Taylor P, et al. Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience. European Journal of Endocrinology. 2003;148(5):491-495. doi: 10.1530/eje.0.1480491</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sridama V, DeGroot LJ. Treatment of Graves' disease and the course of ophthalmopathy. The American Journal of Medicine. 1989;87(1):70-73. doi: 10.1016/s0002-9343(89)80485-1</mixed-citation><mixed-citation xml:lang="en">Sridama V, DeGroot LJ. Treatment of Graves' disease and the course of ophthalmopathy. The American Journal of Medicine. 1989;87(1):70-73. doi: 10.1016/s0002-9343(89)80485-1</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum. Thyroid. 2011;21(10):1081-1125. doi: 10.1089/thy.2011.0087</mixed-citation><mixed-citation xml:lang="en">Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum. Thyroid. 2011;21(10):1081-1125. doi: 10.1089/thy.2011.0087</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Thornton J, Kelly SP, Harrison RA, Edwards R. Cigarette smoking and thyroid eye disease: a systematic review. Eye. 2006;21(9):1135-1145. doi: 10.1038/sj.eye.6702603</mixed-citation><mixed-citation xml:lang="en">Thornton J, Kelly SP, Harrison RA, Edwards R. Cigarette smoking and thyroid eye disease: a systematic review. Eye. 2006;21(9):1135-1145. doi: 10.1038/sj.eye.6702603</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Toft AD. Subclinical Hyperthyroidism. New England Journal of Medicine. 2001;345(7):512-516. doi: 10.1056/NEJMcp010145</mixed-citation><mixed-citation xml:lang="en">Toft AD. Subclinical Hyperthyroidism. New England Journal of Medicine. 2001;345(7):512-516. doi: 10.1056/NEJMcp010145</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wallaschofski H, Orda C, Georgi P, Miehle K, Paschke R. Distinction Between Autoimmune and Non-Autoimmune Hyperthyroidism by Determination of TSH-Receptor Antibodies in Patients with the Initial Diagnosis of Toxic Multinodular Goiter. Hormone and Metabolic Research. 2001;33(8):504-507. doi: 10.1055/s-2001-16945</mixed-citation><mixed-citation xml:lang="en">Wallaschofski H, Orda C, Georgi P, Miehle K, Paschke R. Distinction Between Autoimmune and Non-Autoimmune Hyperthyroidism by Determination of TSH-Receptor Antibodies in Patients with the Initial Diagnosis of Toxic Multinodular Goiter. Hormone and Metabolic Research. 2001;33(8):504-507. doi: 10.1055/s-2001-16945</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Weetman AP. Graves' Disease. New England Journal of Medicine. 2000;343(17):1236-1248. doi: 10.1056/nejm200010263431707</mixed-citation><mixed-citation xml:lang="en">Weetman AP. Graves' Disease. New England Journal of Medicine. 2000;343(17):1236-1248. doi: 10.1056/nejm200010263431707</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Werga-Kjellman P, Zedenius J, Tallstedt L, Träisk F, Lundell G, Wallin G. Surgical Treatment of Hyperthyroidism: A Ten-Year Experience. Thyroid. 2001;11(2):187-192. doi: 10.1089/105072501300042947</mixed-citation><mixed-citation xml:lang="en">Werga-Kjellman P, Zedenius J, Tallstedt L, Träisk F, Lundell G, Wallin G. Surgical Treatment of Hyperthyroidism: A Ten-Year Experience. Thyroid. 2001;11(2):187-192. doi: 10.1089/105072501300042947</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wiersinga WM, Bartalena L. Epidemiology and Prevention of Graves' Ophthalmopathy. Thyroid. 2002;12(10):855-860. doi: 10.1089/105072502761016476</mixed-citation><mixed-citation xml:lang="en">Wiersinga WM, Bartalena L. Epidemiology and Prevention of Graves' Ophthalmopathy. Thyroid. 2002;12(10):855-860. doi: 10.1089/105072502761016476</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Wiersinga WM, Perros P, Kahaly GJ, Mourits MP, Baldeschi L, Boboridis K, et al. Clinical assessment of patients with Graves' orbitopathy: the European Group on Graves' Orbitopathy recommendations to generalists, specialists and clinical researchers. European Journal of Endocrinology. 2006;155(3):387-389. doi: 10.1530/eje.1.02230</mixed-citation><mixed-citation xml:lang="en">Wiersinga WM, Perros P, Kahaly GJ, Mourits MP, Baldeschi L, Boboridis K, et al. Clinical assessment of patients with Graves' orbitopathy: the European Group on Graves' Orbitopathy recommendations to generalists, specialists and clinical researchers. European Journal of Endocrinology. 2006;155(3):387-389. doi: 10.1530/eje.1.02230</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
