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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl20135964-18</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-7061</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Федеральные клинические рекомендации по клинике, диагностике, дифференциальной диагностике и методам лечения акромегалии</article-title><trans-title-group xml:lang="en"><trans-title>RUSSIAN ASSOCIATION OF ENDOCRINOLOGISTS NATIONAL PRACTICE GUIDELINES (CLINICAL SIGNS, DIAGNOSIS, DIFFERENTIAL DIAGNOSIS, TREATMENT). Acromegaly</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дедов</surname><given-names>Иван Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Dedov</surname><given-names>I I</given-names></name></name-alternatives><email xlink:type="simple">dedov@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молитвословова</surname><given-names>Наталья Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Molitvoslovova</surname><given-names>N N</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рожинская</surname><given-names>Людмила Яклвлевна</given-names></name><name name-style="western" xml:lang="en"><surname>Rozhinskaia</surname><given-names>L Ia</given-names></name></name-alternatives><email xlink:type="simple">rozhinskaya@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельниченко</surname><given-names>Галина Афанасьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Mel'nichenko</surname><given-names>G A</given-names></name></name-alternatives><email xlink:type="simple">teofrast2000@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Институт клинической эндокринологии ФГБУ "Эндокринологический научный центр" Минздрава РФ, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2013</year></pub-date><volume>59</volume><issue>6</issue><issue-title>ТОМ 59, №6 (2013)</issue-title><fpage>4</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дедов И.И., Молитвословова Н.Н., Рожинская Л.Я., Мельниченко Г.А., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Дедов И.И., Молитвословова Н.Н., Рожинская Л.Я., Мельниченко Г.А.</copyright-holder><copyright-holder xml:lang="en">Dedov I.I., Molitvoslovova N.N., Rozhinskaia L.I., Mel'nichenko G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/7061">https://www.probl-endojournals.ru/jour/article/view/7061</self-uri><abstract><p>Клинические рекомендации были составлены Г.А. Мельниченко, Н.Н. Молитвослововой, Л.Я. Рожинской, И.И. Дедовым в мае 2013 г. В июне 2013 г. разосланы всем остальным членам рабочей группы (состав рабочей группы представлен ниже), были получены дополнения и замечания, которые внесены и учтены, затем вновь разосланы членам рабочей группы, получено их согласие на публикацию. В июле 2013 г. рекомендации были направлены рецензентам, в августе 2013 г. получены от всех рецензентов положительные отзывы, после чего клинические рекомендации были опубликованы на сайте Российской ассоциации эндокринологов для дальнейшего обсуждения</p><p>Рабочая группа по созданию Клинических рекомендаций по акромегалии Российской ассоциации эндокринологов</p></abstract><trans-abstract xml:lang="en"><p>-</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А. Акромегалия: патогенез, клиника, диагностика, дифференциальная диагностика, методы лечения. Пособие для врачей. М 2012.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А. Акромегалия: патогенез, клиника, диагностика, дифференциальная диагностика, методы лечения. Пособие для врачей. М 2012.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Молитвословова Н.Н., Рожинская Л.Я., Мельниченко Г.А. Российский консенсус по диагностике, лечению и мониторингу акромегалии (проект). Пробл эндокринол 2007; 53: 4: 37-42.</mixed-citation><mixed-citation xml:lang="en">Молитвословова Н.Н., Рожинская Л.Я., Мельниченко Г.А. Российский консенсус по диагностике, лечению и мониторингу акромегалии (проект). Пробл эндокринол 2007; 53: 4: 37-42.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Melmed S., Colao A., Barkan A., Molitch M., Grossman A.B., Kleinberg D., Clemmons D., Chanson P., Laws E., Schlechte J., Vance M.L., Ho K., Giustina A. Acromegaly Consensus Group. Guidelines for acromegaly management: an update. J Clin Endocrinol Metabol 2009; 94: 5: 1509-1517. doi: 10.1210/jc.2008-2421.</mixed-citation><mixed-citation xml:lang="en">Melmed S., Colao A., Barkan A., Molitch M., Grossman A.B., Kleinberg D., Clemmons D., Chanson P., Laws E., Schlechte J., Vance M.L., Ho K., Giustina A. Acromegaly Consensus Group. Guidelines for acromegaly management: an update. J Clin Endocrinol Metabol 2009; 94: 5: 1509-1517. doi: 10.1210/jc.2008-2421.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Giustina A., Chanson P., Bronstein M.D., Klibanski A., Lamberts S., Casanueva F.F., Trainer P., Ghigo E., Ho K., Melmed S., Acromegaly Consensus Group. A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metabol 2010; 95: 7: 3141-3148. doi: 10.1210/jc.2009-2670.</mixed-citation><mixed-citation xml:lang="en">Giustina A., Chanson P., Bronstein M.D., Klibanski A., Lamberts S., Casanueva F.F., Trainer P., Ghigo E., Ho K., Melmed S., Acromegaly Consensus Group. A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metabol 2010; 95: 7: 3141-3148. doi: 10.1210/jc.2009-2670.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Melmed S., Casanueva F.F., Klibanski A., Bronstein M.D., Chanson P., Lamberts S.W., Strasburger C.J., Wass J.A., Giustina A. A consensus on the diagnosis and treatment of acromegaly complications. Pituitary 2012.</mixed-citation><mixed-citation xml:lang="en">Melmed S., Casanueva F.F., Klibanski A., Bronstein M.D., Chanson P., Lamberts S.W., Strasburger C.J., Wass J.A., Giustina A. A consensus on the diagnosis and treatment of acromegaly complications. Pituitary 2012.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Katznelson L., Atkinson J.L., Cook D.M., Ezzat S.Z., Hamrahian A.H., Miller K.K. AACE Acromegaly Task Force. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly-2011 update: executive summary. Endocr Pract 2011; 17: 4: 636-646.</mixed-citation><mixed-citation xml:lang="en">Katznelson L., Atkinson J.L., Cook D.M., Ezzat S.Z., Hamrahian A.H., Miller K.K. AACE Acromegaly Task Force. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly-2011 update: executive summary. Endocr Pract 2011; 17: 4: 636-646.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ronchi C.L., Boschetti M., Degli Uberti E.C., Mariotti S., Grottoli S., Loli P., Lombardi G., Tamburrano G., Arvigo M., Angeletti G., Boscani P.F., Beck-Peccoz P., Arosio M. Italian Multicenter Autogel Study Group in Acromegaly. Efficacy of a slow-release formulation of lanreotide (Autogel) 120 mg) in patients with acromegaly previously treated with octreotide long acting release (LAR): an open, multicentre longitudinal study. Clin Endocrinol (Oxf) 2007; 67: 4: 512-519.</mixed-citation><mixed-citation xml:lang="en">Ronchi C.L., Boschetti M., Degli Uberti E.C., Mariotti S., Grottoli S., Loli P., Lombardi G., Tamburrano G., Arvigo M., Angeletti G., Boscani P.F., Beck-Peccoz P., Arosio M. Italian Multicenter Autogel Study Group in Acromegaly. Efficacy of a slow-release formulation of lanreotide (Autogel) 120 mg) in patients with acromegaly previously treated with octreotide long acting release (LAR): an open, multicentre longitudinal study. Clin Endocrinol (Oxf) 2007; 67: 4: 512-519.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Le Corvoisier P., Hittinger L., Chanson P., Montagne O., Macquin-Mavier I., Maison P. Cardiac effects of growth hormone treatment in chronic heart failure: A meta-analysis. J Clin Endocrinol Metabol 2007; 92: 1: 180-185.</mixed-citation><mixed-citation xml:lang="en">Le Corvoisier P., Hittinger L., Chanson P., Montagne O., Macquin-Mavier I., Maison P. Cardiac effects of growth hormone treatment in chronic heart failure: A meta-analysis. J Clin Endocrinol Metabol 2007; 92: 1: 180-185.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Melmed S., Sternberg R., Cook D., Klibanski A., Chanson P., Bonert V., Vance M.L., Rhew D., Kleinberg D., Barkan A. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metabol 2005; 90: 7: 4405-4410.</mixed-citation><mixed-citation xml:lang="en">Melmed S., Sternberg R., Cook D., Klibanski A., Chanson P., Bonert V., Vance M.L., Rhew D., Kleinberg D., Barkan A. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metabol 2005; 90: 7: 4405-4410.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Caron P., Bevan J., Clermont A., Maisonobe P. Early and sustained tumour volume reduction and GH/IGF1 control in patients with GH-secreting pituitary macroadenoma primarily treated with lanreotide Autogel 120 mg for 48 weeks: the PRIMARYS study. The 15th European congress of Endocrinology. Endocrinology 2013.</mixed-citation><mixed-citation xml:lang="en">Caron P., Bevan J., Clermont A., Maisonobe P. Early and sustained tumour volume reduction and GH/IGF1 control in patients with GH-secreting pituitary macroadenoma primarily treated with lanreotide Autogel 120 mg for 48 weeks: the PRIMARYS study. The 15th European congress of Endocrinology. Endocrinology 2013.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Melmed S., Cook D., Schopohl J., Goth M.I., Lam K.S., Marek J. Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary 2010; 13: 1: 18-28.</mixed-citation><mixed-citation xml:lang="en">Melmed S., Cook D., Schopohl J., Goth M.I., Lam K.S., Marek J. Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary 2010; 13: 1: 18-28.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Andries M., Glintborg D., Kvistborg A., Hagen C., Andersen M. A 12-month randomized crossover study on the effects of lanreotide Autogel and octreotide long-acting repeatable on GH and IGF-l in patients with acromegaly. Clin Endocrinol (Oxf) 2008; 68: 3: 473-480.</mixed-citation><mixed-citation xml:lang="en">Andries M., Glintborg D., Kvistborg A., Hagen C., Andersen M. A 12-month randomized crossover study on the effects of lanreotide Autogel and octreotide long-acting repeatable on GH and IGF-l in patients with acromegaly. Clin Endocrinol (Oxf) 2008; 68: 3: 473-480.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Croxtall J.D., Scott L.J. Lanreotide Autogel: a review of its use in the management of acromegaly. Drugs 2008; 68: 5: 711-723.</mixed-citation><mixed-citation xml:lang="en">Croxtall J.D., Scott L.J. Lanreotide Autogel: a review of its use in the management of acromegaly. Drugs 2008; 68: 5: 711-723.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Murray R.D., Melmed S. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J Clin Endocrinol Metabol 2008; 93: 8: 2957-2968. doi: 10.1210/jc.2008-0027.</mixed-citation><mixed-citation xml:lang="en">Murray R.D., Melmed S. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J Clin Endocrinol Metabol 2008; 93: 8: 2957-2968. doi: 10.1210/jc.2008-0027.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Roelfsema F., Biermasz N.R., Pereira A.M., Romijn J.A. Therapeutic options in the management of acromegaly: focus on lanreotide Autogel. Biologics 2008; 2: 3: 463-479.</mixed-citation><mixed-citation xml:lang="en">Roelfsema F., Biermasz N.R., Pereira A.M., Romijn J.A. Therapeutic options in the management of acromegaly: focus on lanreotide Autogel. Biologics 2008; 2: 3: 463-479.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lucas T., Astorga R. Spanish-Portuguese Multicentre Autogel Study Group on Acromegaly. Efficacy of lanreotide Autogel administered every 4-8 weeks in patients with acromegaly previously responsive to lanreotide microparticles 30 mg: a phase III trial. Clin Endocrinol (Oxf) 2006; 65: 3: 320-326.</mixed-citation><mixed-citation xml:lang="en">Lucas T., Astorga R. Spanish-Portuguese Multicentre Autogel Study Group on Acromegaly. Efficacy of lanreotide Autogel administered every 4-8 weeks in patients with acromegaly previously responsive to lanreotide microparticles 30 mg: a phase III trial. Clin Endocrinol (Oxf) 2006; 65: 3: 320-326.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Schopohl J., Strasburger C.J., Caird D., Badenhoop K., Beuschlein F., Droste M., Plöckinger U., Petersenn S. German Lanreotide Study Group. Efficacy and acceptability of lanreotide Autogel 120 mg at different dose intervals in patients with acromegaly previously treated with octreotide LAR. Exp Clin Endocrinol Diabetes 2011; 119: 3: 156-162.</mixed-citation><mixed-citation xml:lang="en">Schopohl J., Strasburger C.J., Caird D., Badenhoop K., Beuschlein F., Droste M., Plöckinger U., Petersenn S. German Lanreotide Study Group. Efficacy and acceptability of lanreotide Autogel 120 mg at different dose intervals in patients with acromegaly previously treated with octreotide LAR. Exp Clin Endocrinol Diabetes 2011; 119: 3: 156-162.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bevan J.S., Newell-Price J., Wass J.A., Atkin S.L., Bouloux P.M., Chapman J., Davis J.R., Howlett T.A., Randeva H.S., Stewart P.M., Viswanath A. Home administration of lanreotide Autogel by patients with acromegaly, or their partners, is safe and effective. Clin Endocrinol (Oxf) 2008; 68: 3: 343-349.</mixed-citation><mixed-citation xml:lang="en">Bevan J.S., Newell-Price J., Wass J.A., Atkin S.L., Bouloux P.M., Chapman J., Davis J.R., Howlett T.A., Randeva H.S., Stewart P.M., Viswanath A. Home administration of lanreotide Autogel by patients with acromegaly, or their partners, is safe and effective. Clin Endocrinol (Oxf) 2008; 68: 3: 343-349.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Caron P., Cogne M., Raingeard I., Bex-Bachellerie V., Kuhn J.M. Effectiveness and tolerability of 3-year lanreotide Autogel treatment in patients with acromegaly. Clin Endocrinol (Oxf) 2006; 64: 2: 209-214.</mixed-citation><mixed-citation xml:lang="en">Caron P., Cogne M., Raingeard I., Bex-Bachellerie V., Kuhn J.M. Effectiveness and tolerability of 3-year lanreotide Autogel treatment in patients with acromegaly. Clin Endocrinol (Oxf) 2006; 64: 2: 209-214.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gutt B., Bidlingmaier M., Kretschmar K. et al. Four-year follow-up of acromegalic patients treated with the new long-acting formulation of Lanreotide (Lanreotide Autogel). Exp Clin Endocrinol Diabetes 2005; 113: 3: 139-144.</mixed-citation><mixed-citation xml:lang="en">Gutt B., Bidlingmaier M., Kretschmar K. et al. Four-year follow-up of acromegalic patients treated with the new long-acting formulation of Lanreotide (Lanreotide Autogel). Exp Clin Endocrinol Diabetes 2005; 113: 3: 139-144.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Florio T., Thellung S., Corsaro A. et al. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro. Clin Endocrinol (Oxf) 2003; 59: 115-128.</mixed-citation><mixed-citation xml:lang="en">Florio T., Thellung S., Corsaro A. et al. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro. Clin Endocrinol (Oxf) 2003; 59: 115-128.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wasko R., Jankowska A., Kotwicka M., Liebert W., Sowinski J., Warchol J.B. Effects of treatment with somatostatin analogues on the occurrence of apoptosis in somatotropinomas. Neuro Endocrinol Lett 2003; 24: 5: 334-338.</mixed-citation><mixed-citation xml:lang="en">Wasko R., Jankowska A., Kotwicka M., Liebert W., Sowinski J., Warchol J.B. Effects of treatment with somatostatin analogues on the occurrence of apoptosis in somatotropinomas. Neuro Endocrinol Lett 2003; 24: 5: 334-338.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Alexopoulou O., Abrams P., Verhelst J. et al. Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR. Eur J Endocrinol 2004; 151: 317-324.</mixed-citation><mixed-citation xml:lang="en">Alexopoulou O., Abrams P., Verhelst J. et al. Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR. Eur J Endocrinol 2004; 151: 317-324.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Attanasio R., Lanzi R., Losa M. et al. Effects of lanreotide Autogel on growth hormone, insulinlike growth factor 1, and tumor size in acromegaly: a 1-year prospective multicenter study. Endocrinol Pract 2008; 14: 7: 846-855.</mixed-citation><mixed-citation xml:lang="en">Attanasio R., Lanzi R., Losa M. et al. Effects of lanreotide Autogel on growth hormone, insulinlike growth factor 1, and tumor size in acromegaly: a 1-year prospective multicenter study. Endocrinol Pract 2008; 14: 7: 846-855.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Baldelli R., Ferretti E., Jaffrain-Rea M. et al. Cardiac effects of slow-release lanreotide, a slow-release somatostatin analog, in acromegalic patients. J Clin Endocrinol Metabol 1999; 84: 527-532.</mixed-citation><mixed-citation xml:lang="en">Baldelli R., Ferretti E., Jaffrain-Rea M. et al. Cardiac effects of slow-release lanreotide, a slow-release somatostatin analog, in acromegalic patients. J Clin Endocrinol Metabol 1999; 84: 527-532.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hradec J., Krai J., Janota T. et al. Regression of acromegalic left ventricular hypertrophy after lanreotide (a slow-release somatostatin analog). Am J Cardiol 1999; 83: 1506-1509.</mixed-citation><mixed-citation xml:lang="en">Hradec J., Krai J., Janota T. et al. Regression of acromegalic left ventricular hypertrophy after lanreotide (a slow-release somatostatin analog). Am J Cardiol 1999; 83: 1506-1509.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lombardi G., Colao A., Marzullo P. et al. Multicenter Italian Study Group on Lanreotide. Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center study. J Endocrinol Invest 2002; 25: 11: 971-976.</mixed-citation><mixed-citation xml:lang="en">Lombardi G., Colao A., Marzullo P. et al. Multicenter Italian Study Group on Lanreotide. Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center study. J Endocrinol Invest 2002; 25: 11: 971-976.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Magyar D.M., Marshall J.R. Pituitary tumors and pregnancy. Am J Obstet Gynecol 1978; 132: 739-751.</mixed-citation><mixed-citation xml:lang="en">Magyar D.M., Marshall J.R. Pituitary tumors and pregnancy. Am J Obstet Gynecol 1978; 132: 739-751.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
