problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl201561232-38problendo-7204Research ArticleСтатьиArticlesКонфокальная микроскопия роговицы - новый неинвазивный метод диагностики начальных проявлений повреждения периферической нервной системы при сахарном диабетеConfocal retinal microscopy - the new non-invasive method for diagnostics of the early manifestations of the lesions in the peripheral nervous system associated with diabetes mellitusАртемоваЕ ВArtemovaE V-ГалстянГ РGalstyanG Rgalstyangagik964@gmail.comАтарщиковД СAtarshchikovD S-МальчугинаА АMalchuginaA A-ДедовИ ИDedovI I-ФГБУ «Эндокринологический научный центр» Минздрава России, МоскваEndocrinology Research Centre, Moscow201515042015612ТОМ 61, №2 (2015)3238Copyright © Артемова Е.В., Галстян Г.Р., Атарщиков Д.С., Мальчугина А.А., Дедов И.И., 20152015Артемова Е.В., Галстян Г.Р., Атарщиков Д.С., Мальчугина А.А., Дедов И.И.Artemova E.V., Galstyan G.R., Atarshchikov D.S., Malchugina A.A., Dedov I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/7204

В настоящее время не существует надежных способов диагностики начальных проявлений повреждения периферической нервной системы. Только пункционная биопсия кожи и биопсия нервов могут быть использованы на доклинической стадии, однако эти методы инвазивны и сопряжены с риском инфекционных осложнений. Конфокальная микроскопия роговицы - новый неинвазивный морфометрический метод, позволяющий выявлять признаки раннего повреждения периферической нервной системы и исследовать динамику изменений, что может служить суррогатной точкой для оценки терапевтической эффективности лекарственных препаратов.

There are presently no reliable methods for diagnostics of the early manifestations of the lesions in the peripheral nervous system. Only puncture biopsy of the skin and the nerves can be used at the preclinical stage. However, the application of these invasive methods is fraught with the risk of infectious complications. Confocal retinal microscopy is the new non-invasive morphometric technique that permits to reveal the early signs of the lesions in the peripheral nervous system and to study dynamics of the associated changes that can be used as a valid surrogate end point for the evaluation of the effectiveness of pharmacotherapy.

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The authors declare that there are no conflicts of interest present.