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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">problendo</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы Эндокринологии</journal-title><trans-title-group xml:lang="en"><trans-title>Problems of Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0375-9660</issn><issn pub-type="epub">2308-1430</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/probl201561556-59</article-id><article-id custom-type="elpub" pub-id-type="custom">problendo-7668</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Возможности ранней комбинированной терапии сахарного диабета 2-го типа</article-title><trans-title-group xml:lang="en"><trans-title>Possible benefits of early combination therapy of type 2 diabetes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шестакова</surname><given-names>Екатерина Алексеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Shestakova</surname><given-names>Ekaterina Alekseevna</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, научный сотрудник отделения интервенционной кардиологии</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">katiashestakova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Эндокринологический научный центр» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2015</year></pub-date><volume>61</volume><issue>5</issue><fpage>56</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шестакова Е.А., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Шестакова Е.А.</copyright-holder><copyright-holder xml:lang="en">Shestakova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.probl-endojournals.ru/jour/article/view/7668">https://www.probl-endojournals.ru/jour/article/view/7668</self-uri><abstract><p>Ряд современных алгоритмов терапии сахарного диабета 2 типа предусматривает старт интенсивной сахароснижающей терапии при уровне HbA1c более 7,5% на момент постановки диагноза. Статья рассматривает возможные преимущества комбинированной сахароснижающей терапии в дебюте сахарного диабета 2 типа. </p><p> </p></abstract><trans-abstract xml:lang="en"><p>Some current international and national guidelines for type 2 diabetes recommend intensive start of antidiabetic treatment if HbA1c is more than 7.5% at the moment of diagnosis of type 2 diabetes. The article speculates on the possible benefits of combination therapy at the very early stages of type 2 diabetes progression.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2-го типа</kwd><kwd>комбинированная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes</kwd><kwd>combination therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В., Галстян Г.Р., и др. “Алгоритмы специализированной медицинской помощи больным сахарным диабетом”. 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